Pretreatment EGFR T790M Mutation and BRCA1 mRNA Expression in Erlotinib-Treated Advanced Non-Small-Cell Lung Cancer Patients with EGFR Mutations

Advanced non-small-cell lung cancer (NSCLC) patients harboring epidermal growth factor receptor (EGFR) mutations (deletion in exon 19 or L858R) show an impressive progression-free survival of 14 months when treated with erlotinib. However, the presence of EGFR mutations can only imperfectly predict...

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Veröffentlicht in:	Clinical cancer research 2011-03, Vol.17 (5), p.1160-1168
Hauptverfasser:	ROSELL, Rafael, ANGEL MOLINA, Miguel, ISLA, Dolores, PROVENCIO, Mariano, COBO, Manuel, INSA, Amelia, GARCIA-CAMPELO, Rosario, REGUART, Noemi, MAJEM, Margarita, VITERI, Santiago, CARCERENY, Enric, PORTA, Ruth, COSTA, Carlota, MASSUTI, Bartomeu, QUERALT, Cristina, DE AGUIRRE, Itziar, SANCHEZ, Jose Miguel, SANCHEZ-RONCO, Maria, MATE, Jose Luis, ARIZA, Aurelio, BENLLOCH, Susana, SANCHEZ, Jose Javier, BIVONA, Trever G, SIMONETTI, Sara, SAWYERS, Charles L, TARON, Miquel, GIMENEZ-CAPITAN, Ana, BERTRAN-ALAMILLO, Jordi, MAYO, Clara, MORAN, Teresa, MENDEZ, Pedro, CARDENAL, Felipe
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic agents Antineoplastic Agents - therapeutic use Biological and medical sciences Biomarkers, Tumor BRCA1 Protein - genetics Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Disease-Free Survival DNA Repair - genetics Erlotinib Hydrochloride Female Gene Expression Genes, BRCA1 Genes, erbB-1 Humans Lung Neoplasms - drug therapy Lung Neoplasms - genetics Male Medical sciences Middle Aged Mutation Pharmacology. Drug treatments Pneumology Protein Kinase Inhibitors - therapeutic use Quinazolines - therapeutic use Receptor Protein-Tyrosine Kinases - metabolism Receptor, Epidermal Growth Factor - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Treatment Outcome Tumors of the respiratory system and mediastinum
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