Antibodies to DNA in the blood of patients with tick-borne encephalitis
A comparison of relative levels of autoantibodies (Abs) to both native (n) and denatured (d) DNA in the blood of 55 patients with tick-borne encephalitis (TBE) was carried out. 31% of patients with TBE was shown to have an increased level Abs to nDNA and 40% of patients demonstrate increased level o...
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| Veröffentlicht in: | Molecular biology (New York) 2004-07, Vol.38 (4), p.723-614 |
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| creator | Garmashova, N V Kazanskiĭ, V E Tyshkevich, O B Doronin, B M Buneva, V N Nevinskiĭ, G A |
| description | A comparison of relative levels of autoantibodies (Abs) to both native (n) and denatured (d) DNA in the blood of 55 patients with tick-borne encephalitis (TBE) was carried out. 31% of patients with TBE was shown to have an increased level Abs to nDNA and 40% of patients demonstrate increased level of Abs to dDNA. The percent of TBE patients with increased concentration of anti-nDNA Abs higher then that in patients with multiple sclerosis (18%) and some other autoimmune diseases (6-18%), but comparable with that for patients with systemic lupus erythematosus (38%) and polymyositis (42%). In contrast to patients with systemic lupus erythematosus and multiple sclerosis, the level of Abs to nDNA in patients with TBE is higher than the level of Abs to dDNA. Correlation coefficients of Ab levels to both n- and dDNA were estimated for group of patients in whole and for separate subgroups with different type of disease (temperature reaction, feverishness and meningitis). Analysis of correlation between titres of anti-DNA Abs and three standard biochemical markers of TBE (activity of aspartate- and alanine-aminotransferases, and concentration of whole bilirubin) for 22 patients with TBE was carried out. Statistically significant correlation was revealed only between the level of Abs to nDNA and activities of aspartate- and alanine-aminotransferases, correlation coefficients are equal to +0.44 and +0.48, respectively. |
| doi_str_mv | 10.1023/B:MBIL.0000037015.63290.23 |
| format | Article |
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The percent of TBE patients with increased concentration of anti-nDNA Abs higher then that in patients with multiple sclerosis (18%) and some other autoimmune diseases (6-18%), but comparable with that for patients with systemic lupus erythematosus (38%) and polymyositis (42%). In contrast to patients with systemic lupus erythematosus and multiple sclerosis, the level of Abs to nDNA in patients with TBE is higher than the level of Abs to dDNA. Correlation coefficients of Ab levels to both n- and dDNA were estimated for group of patients in whole and for separate subgroups with different type of disease (temperature reaction, feverishness and meningitis). Analysis of correlation between titres of anti-DNA Abs and three standard biochemical markers of TBE (activity of aspartate- and alanine-aminotransferases, and concentration of whole bilirubin) for 22 patients with TBE was carried out. Statistically significant correlation was revealed only between the level of Abs to nDNA and activities of aspartate- and alanine-aminotransferases, correlation coefficients are equal to +0.44 and +0.48, respectively.</description><identifier>ISSN: 0026-8984</identifier><identifier>ISSN: 0026-8933</identifier><identifier>EISSN: 1608-3245</identifier><identifier>DOI: 10.1023/B:MBIL.0000037015.63290.23</identifier><identifier>PMID: 15456145</identifier><language>eng</language><publisher>Russia (Federation): Springer Nature B.V</publisher><subject>Alanine transaminase ; Anti-DNA antibodies ; Antibodies, Viral - blood ; Aspartate aminotransferase ; Autoantibodies ; Autoimmune diseases ; Bilirubin ; Bilirubin - blood ; Biochemical markers ; Blood ; Deoxyribonucleic acid ; DNA ; DNA, Viral - immunology ; Encephalitis Viruses, Tick-Borne - genetics ; Enzymes ; Humans ; Immunoenzyme Techniques ; Lupus ; Multiple sclerosis ; Polymyositis ; Statistical analysis ; Systemic lupus erythematosus ; Temperature effects ; Tick-borne encephalitis</subject><ispartof>Molecular biology (New York), 2004-07, Vol.38 (4), p.723-614</ispartof><rights>MAIK "Nauka/Interperiodica" 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-9b8530d9b03ed510511d681d1b79eb5dac453543c798589de8699e4a3b5d9fb33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15456145$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garmashova, N V</creatorcontrib><creatorcontrib>Kazanskiĭ, V E</creatorcontrib><creatorcontrib>Tyshkevich, O B</creatorcontrib><creatorcontrib>Doronin, B M</creatorcontrib><creatorcontrib>Buneva, V N</creatorcontrib><creatorcontrib>Nevinskiĭ, G A</creatorcontrib><title>Antibodies to DNA in the blood of patients with tick-borne encephalitis</title><title>Molecular biology (New York)</title><addtitle>Mol Biol (Mosk)</addtitle><description>A comparison of relative levels of autoantibodies (Abs) to both native (n) and denatured (d) DNA in the blood of 55 patients with tick-borne encephalitis (TBE) was carried out. 31% of patients with TBE was shown to have an increased level Abs to nDNA and 40% of patients demonstrate increased level of Abs to dDNA. The percent of TBE patients with increased concentration of anti-nDNA Abs higher then that in patients with multiple sclerosis (18%) and some other autoimmune diseases (6-18%), but comparable with that for patients with systemic lupus erythematosus (38%) and polymyositis (42%). In contrast to patients with systemic lupus erythematosus and multiple sclerosis, the level of Abs to nDNA in patients with TBE is higher than the level of Abs to dDNA. Correlation coefficients of Ab levels to both n- and dDNA were estimated for group of patients in whole and for separate subgroups with different type of disease (temperature reaction, feverishness and meningitis). Analysis of correlation between titres of anti-DNA Abs and three standard biochemical markers of TBE (activity of aspartate- and alanine-aminotransferases, and concentration of whole bilirubin) for 22 patients with TBE was carried out. Statistically significant correlation was revealed only between the level of Abs to nDNA and activities of aspartate- and alanine-aminotransferases, correlation coefficients are equal to +0.44 and +0.48, respectively.</description><subject>Alanine transaminase</subject><subject>Anti-DNA antibodies</subject><subject>Antibodies, Viral - blood</subject><subject>Aspartate aminotransferase</subject><subject>Autoantibodies</subject><subject>Autoimmune diseases</subject><subject>Bilirubin</subject><subject>Bilirubin - blood</subject><subject>Biochemical markers</subject><subject>Blood</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA, Viral - immunology</subject><subject>Encephalitis Viruses, Tick-Borne - genetics</subject><subject>Enzymes</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Lupus</subject><subject>Multiple sclerosis</subject><subject>Polymyositis</subject><subject>Statistical analysis</subject><subject>Systemic lupus erythematosus</subject><subject>Temperature effects</subject><subject>Tick-borne encephalitis</subject><issn>0026-8984</issn><issn>0026-8933</issn><issn>1608-3245</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkUtLAzEQgIMoWrR_QYIHPW1NMnlsvLW-oepFz2GzSWl0u6mbFPHfu9VCwYPOZWDmmxmGD6ETSkaUMDifXDxM7qcjsg5QhIqRBKbJiMEOGlBJygIYF7toQAiTRalLfoCGKQVLiBQK-sI-OqCCC0m5GKDbcZuDjS74hHPEV49jHFqc5x7bJkaH4wwvqxx8mxP-CHmOc6jfChu71mPf1n45r5qQQzpCe7OqSX64yYfo5eb6-fKumD7d3l-Op0XNiciFtqUA4rQl4J2gRFDqZEkdtUp7K1xVcwGCQ610KUrtfCm19ryCvqdnFuAQnf3sXXbxfeVTNouQat80VevjKhlNOJdKMtWTp3-SUmrGFJf_glQpAAqsB09-ga9x1bX9u0bJ3ganWvfQxQ9UdzGlzs_MsguLqvs0lJi1QTMxa4Nma9B8GzRs_d3x5sLKLrzbjm58wRcWyZTA</recordid><startdate>200407</startdate><enddate>200407</enddate><creator>Garmashova, N V</creator><creator>Kazanskiĭ, V E</creator><creator>Tyshkevich, O B</creator><creator>Doronin, B M</creator><creator>Buneva, V N</creator><creator>Nevinskiĭ, G A</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200407</creationdate><title>Antibodies to DNA in the blood of patients with tick-borne encephalitis</title><author>Garmashova, N V ; Kazanskiĭ, V E ; Tyshkevich, O B ; Doronin, B M ; Buneva, V N ; Nevinskiĭ, G A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-9b8530d9b03ed510511d681d1b79eb5dac453543c798589de8699e4a3b5d9fb33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Alanine transaminase</topic><topic>Anti-DNA antibodies</topic><topic>Antibodies, Viral - 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The percent of TBE patients with increased concentration of anti-nDNA Abs higher then that in patients with multiple sclerosis (18%) and some other autoimmune diseases (6-18%), but comparable with that for patients with systemic lupus erythematosus (38%) and polymyositis (42%). In contrast to patients with systemic lupus erythematosus and multiple sclerosis, the level of Abs to nDNA in patients with TBE is higher than the level of Abs to dDNA. Correlation coefficients of Ab levels to both n- and dDNA were estimated for group of patients in whole and for separate subgroups with different type of disease (temperature reaction, feverishness and meningitis). Analysis of correlation between titres of anti-DNA Abs and three standard biochemical markers of TBE (activity of aspartate- and alanine-aminotransferases, and concentration of whole bilirubin) for 22 patients with TBE was carried out. Statistically significant correlation was revealed only between the level of Abs to nDNA and activities of aspartate- and alanine-aminotransferases, correlation coefficients are equal to +0.44 and +0.48, respectively.</abstract><cop>Russia (Federation)</cop><pub>Springer Nature B.V</pub><pmid>15456145</pmid><doi>10.1023/B:MBIL.0000037015.63290.23</doi><tpages>7</tpages></addata></record> |
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| ispartof | Molecular biology (New York), 2004-07, Vol.38 (4), p.723-614 |
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| subjects | Alanine transaminase Anti-DNA antibodies Antibodies, Viral - blood Aspartate aminotransferase Autoantibodies Autoimmune diseases Bilirubin Bilirubin - blood Biochemical markers Blood Deoxyribonucleic acid DNA DNA, Viral - immunology Encephalitis Viruses, Tick-Borne - genetics Enzymes Humans Immunoenzyme Techniques Lupus Multiple sclerosis Polymyositis Statistical analysis Systemic lupus erythematosus Temperature effects Tick-borne encephalitis |
| title | Antibodies to DNA in the blood of patients with tick-borne encephalitis |
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