VNTR Polymorphisms of the Serotonin Transporter and Dopamine Transporter Genes in Male Opiate Addicts

VNTR Polymorphisms of the Serotonin Transporter and Dopamine Transporter Genes in Male Opiate Addicts

VNTR polymorphisms of the serotonin transporter (hSERT) and dopamine transporter (DAT1) gene were studied in male opiate addicts. Samples of ethnic Russians and ethnic Tatars did not differ in genotype and allele frequencies. Homozygosity at hSERT (especially 10/10) was associated with early opiate...

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Veröffentlicht in:Molecular biology (New York) 2002-07, Vol.36 (4), p.462-466
Hauptverfasser: Galeeva, A R, Gareeva, A E, Yur'ev, E B, Khusnutdinova, E K
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Dopamine
Genotype & phenotype
Methadone
Substance abuse treatment
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creator Galeeva, A R
Gareeva, A E
Yur'ev, E B
Khusnutdinova, E K
description VNTR polymorphisms of the serotonin transporter (hSERT) and dopamine transporter (DAT1) gene were studied in male opiate addicts. Samples of ethnic Russians and ethnic Tatars did not differ in genotype and allele frequencies. Homozygosity at hSERT (especially 10/10) was associated with early opiate addiction, while genotype 12/10 proved to be protective. In the case of DAT1, genotype 9/9 was associated with early opiate addiction. The combination of hSERT genotype 10/10 with DAT1 genotype 10/10 was shown to be a risk factor of opiate abuse under 16 years of age.[PUBLICATION ABSTRACT]
doi_str_mv 10.1023/A:1019883806620
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subjects Dopamine
Genotype & phenotype
Methadone
Substance abuse treatment
title VNTR Polymorphisms of the Serotonin Transporter and Dopamine Transporter Genes in Male Opiate Addicts
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