A basic study on lesion detectability for hot spot imaging of positron emitters with dedicated PET and positron coincidence gamma camera
The aim of this study was to explore the correlations of detectability and the semi-quantification for hot spot imaging with positron emitters in positron emission tomography (PET) and with a positron coincidence detection system (PCD). Phantom study results for the measurement of the lesion-to-back...
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| Veröffentlicht in: | Annals of nuclear medicine 2001-06, Vol.15 (3), p.301-306 |
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| creator | Zhang, H Inoue, T Tian, M Alyafei, S Oriuchi, N Khan, N Li, S Endo, K |
| description | The aim of this study was to explore the correlations of detectability and the semi-quantification for hot spot imaging with positron emitters in positron emission tomography (PET) and with a positron coincidence detection system (PCD). Phantom study results for the measurement of the lesion-to-background (L/B) ratio ranged from 2.0 to 30.3, and detectability for hot spot lesion of PET and PCD were performed to correspond to clinical conditions. The detectability and semi-quantitative evaluation of hot spots from 4.4 mm to 36.9 mm in diameter were performed from the PET and PCD images. There were strong correlations between the L/B ratios derived from PET and PCD hot spot images and actual L/B ratios; but the L/B ratio derived from PET was higher than that from PCD with a significant difference of 10% to 54.8%. The detectability of hot spot imaging of PCD was lower than that of PET at 64.8% (PCD) versus 77.8% (PET). Even the actual L/B ratio was 8.0, hot spots more than 10.6 mm in diameter could be clearly identified with PCD imaging. The same identification could be achieved with PET imaging even when the actual L/B ratio was 4.0. This detailed investigation indicated that FDG PCD yielded results comparable to FDG PET on visual analysis and semi-quantitative analysis in detecting hot spots in phantoms, but semi-quantitative analysis of the L/B ratio with FDG PCD was inferior to that with FDG PET and the detectability of PCD in smaller hot spots was significantly poor. |
| doi_str_mv | 10.1007/BF02987851 |
| format | Article |
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Phantom study results for the measurement of the lesion-to-background (L/B) ratio ranged from 2.0 to 30.3, and detectability for hot spot lesion of PET and PCD were performed to correspond to clinical conditions. The detectability and semi-quantitative evaluation of hot spots from 4.4 mm to 36.9 mm in diameter were performed from the PET and PCD images. There were strong correlations between the L/B ratios derived from PET and PCD hot spot images and actual L/B ratios; but the L/B ratio derived from PET was higher than that from PCD with a significant difference of 10% to 54.8%. The detectability of hot spot imaging of PCD was lower than that of PET at 64.8% (PCD) versus 77.8% (PET). Even the actual L/B ratio was 8.0, hot spots more than 10.6 mm in diameter could be clearly identified with PCD imaging. The same identification could be achieved with PET imaging even when the actual L/B ratio was 4.0. This detailed investigation indicated that FDG PCD yielded results comparable to FDG PET on visual analysis and semi-quantitative analysis in detecting hot spots in phantoms, but semi-quantitative analysis of the L/B ratio with FDG PCD was inferior to that with FDG PET and the detectability of PCD in smaller hot spots was significantly poor.</description><identifier>ISSN: 0914-7187</identifier><identifier>EISSN: 1864-6433</identifier><identifier>DOI: 10.1007/BF02987851</identifier><identifier>PMID: 11545207</identifier><language>eng</language><publisher>Japan: Springer Nature B.V</publisher><subject>Diameters ; Emitters ; Gamma Cameras ; Humans ; Imaging ; Lesions ; Medical imaging ; Models, Biological ; Phantoms, Imaging ; Positron emission ; Positron emission tomography ; Quantitative analysis ; Radiopharmaceuticals - pharmacokinetics ; Regression Analysis ; Sensitivity and Specificity ; Tomography ; Tomography, Emission-Computed - instrumentation ; Tomography, Emission-Computed - methods</subject><ispartof>Annals of nuclear medicine, 2001-06, Vol.15 (3), p.301-306</ispartof><rights>Springer 2001</rights><rights>Springer 2001.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-3eeb8bd1d777c0451ba756592cd6e3ef8666c7fee75599925e295a6b662bcc2d3</citedby><cites>FETCH-LOGICAL-c454t-3eeb8bd1d777c0451ba756592cd6e3ef8666c7fee75599925e295a6b662bcc2d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11545207$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, H</creatorcontrib><creatorcontrib>Inoue, T</creatorcontrib><creatorcontrib>Tian, M</creatorcontrib><creatorcontrib>Alyafei, S</creatorcontrib><creatorcontrib>Oriuchi, N</creatorcontrib><creatorcontrib>Khan, N</creatorcontrib><creatorcontrib>Li, S</creatorcontrib><creatorcontrib>Endo, K</creatorcontrib><title>A basic study on lesion detectability for hot spot imaging of positron emitters with dedicated PET and positron coincidence gamma camera</title><title>Annals of nuclear medicine</title><addtitle>Ann Nucl Med</addtitle><description>The aim of this study was to explore the correlations of detectability and the semi-quantification for hot spot imaging with positron emitters in positron emission tomography (PET) and with a positron coincidence detection system (PCD). Phantom study results for the measurement of the lesion-to-background (L/B) ratio ranged from 2.0 to 30.3, and detectability for hot spot lesion of PET and PCD were performed to correspond to clinical conditions. The detectability and semi-quantitative evaluation of hot spots from 4.4 mm to 36.9 mm in diameter were performed from the PET and PCD images. There were strong correlations between the L/B ratios derived from PET and PCD hot spot images and actual L/B ratios; but the L/B ratio derived from PET was higher than that from PCD with a significant difference of 10% to 54.8%. The detectability of hot spot imaging of PCD was lower than that of PET at 64.8% (PCD) versus 77.8% (PET). Even the actual L/B ratio was 8.0, hot spots more than 10.6 mm in diameter could be clearly identified with PCD imaging. The same identification could be achieved with PET imaging even when the actual L/B ratio was 4.0. This detailed investigation indicated that FDG PCD yielded results comparable to FDG PET on visual analysis and semi-quantitative analysis in detecting hot spots in phantoms, but semi-quantitative analysis of the L/B ratio with FDG PCD was inferior to that with FDG PET and the detectability of PCD in smaller hot spots was significantly poor.</description><subject>Diameters</subject><subject>Emitters</subject><subject>Gamma Cameras</subject><subject>Humans</subject><subject>Imaging</subject><subject>Lesions</subject><subject>Medical imaging</subject><subject>Models, Biological</subject><subject>Phantoms, Imaging</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Quantitative analysis</subject><subject>Radiopharmaceuticals - pharmacokinetics</subject><subject>Regression Analysis</subject><subject>Sensitivity and Specificity</subject><subject>Tomography</subject><subject>Tomography, Emission-Computed - instrumentation</subject><subject>Tomography, Emission-Computed - 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Academic</collection><jtitle>Annals of nuclear medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, H</au><au>Inoue, T</au><au>Tian, M</au><au>Alyafei, S</au><au>Oriuchi, N</au><au>Khan, N</au><au>Li, S</au><au>Endo, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A basic study on lesion detectability for hot spot imaging of positron emitters with dedicated PET and positron coincidence gamma camera</atitle><jtitle>Annals of nuclear medicine</jtitle><addtitle>Ann Nucl Med</addtitle><date>2001-06-01</date><risdate>2001</risdate><volume>15</volume><issue>3</issue><spage>301</spage><epage>306</epage><pages>301-306</pages><issn>0914-7187</issn><eissn>1864-6433</eissn><abstract>The aim of this study was to explore the correlations of detectability and the semi-quantification for hot spot imaging with positron emitters in positron emission tomography (PET) and with a positron coincidence detection system (PCD). Phantom study results for the measurement of the lesion-to-background (L/B) ratio ranged from 2.0 to 30.3, and detectability for hot spot lesion of PET and PCD were performed to correspond to clinical conditions. The detectability and semi-quantitative evaluation of hot spots from 4.4 mm to 36.9 mm in diameter were performed from the PET and PCD images. There were strong correlations between the L/B ratios derived from PET and PCD hot spot images and actual L/B ratios; but the L/B ratio derived from PET was higher than that from PCD with a significant difference of 10% to 54.8%. The detectability of hot spot imaging of PCD was lower than that of PET at 64.8% (PCD) versus 77.8% (PET). Even the actual L/B ratio was 8.0, hot spots more than 10.6 mm in diameter could be clearly identified with PCD imaging. The same identification could be achieved with PET imaging even when the actual L/B ratio was 4.0. This detailed investigation indicated that FDG PCD yielded results comparable to FDG PET on visual analysis and semi-quantitative analysis in detecting hot spots in phantoms, but semi-quantitative analysis of the L/B ratio with FDG PCD was inferior to that with FDG PET and the detectability of PCD in smaller hot spots was significantly poor.</abstract><cop>Japan</cop><pub>Springer Nature B.V</pub><pmid>11545207</pmid><doi>10.1007/BF02987851</doi><tpages>6</tpages></addata></record> |
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| ispartof | Annals of nuclear medicine, 2001-06, Vol.15 (3), p.301-306 |
| issn | 0914-7187 1864-6433 |
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| source | MEDLINE; Alma/SFX Local Collection; SpringerLink Journals - AutoHoldings |
| subjects | Diameters Emitters Gamma Cameras Humans Imaging Lesions Medical imaging Models, Biological Phantoms, Imaging Positron emission Positron emission tomography Quantitative analysis Radiopharmaceuticals - pharmacokinetics Regression Analysis Sensitivity and Specificity Tomography Tomography, Emission-Computed - instrumentation Tomography, Emission-Computed - methods |
| title | A basic study on lesion detectability for hot spot imaging of positron emitters with dedicated PET and positron coincidence gamma camera |
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