Decreased perfusion of the bilateral thalami in patients with chronic pain detected by Tc-99m-ECD SPECT with statistical parametric mapping
The purpose of this study was to examine whether the Tc-99m-ECD SPECT can detect any difference between the brain perfusion in patients with chronic pain and normal controls by means of the Statistical Parametric Mapping (SPM96). The subjects were twelve patients with chronic pain (CP group) and twe...
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| Veröffentlicht in: | Annals of nuclear medicine 2001-10, Vol.15 (5), p.459-463 |
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| creator | Nakabeppu, Y Nakajo, M Gushiken, T Tsuchimochi, S Tani, A Kanmura, Y |
| description | The purpose of this study was to examine whether the Tc-99m-ECD SPECT can detect any difference between the brain perfusion in patients with chronic pain and normal controls by means of the Statistical Parametric Mapping (SPM96). The subjects were twelve patients with chronic pain (CP group) and twelve normal controls (NC group). After informed consent was obtained, 720 MBq of Tc-99m-ECD was intravenously injected as a bolus. The SPECT data were acquired once for 20 mins from 5 mins after i.v. injection of Tc-99m-ECD, with a triple-head rotating gamma camera. The SPECT data were transformed into a standard stereotactic space, and group comparisons between CP and NC groups were performed on a voxel-by-voxel basis. The subset of voxels exceeding a threshold of p < 0.001 in omnibus comparisons and remaining significant after correction for multiple comparison (p < 0.05) was displayed as a volume image rendered in three orthogonal projections. There was a significant decrease in perfusion in the bilateral thalami in the CP group, suggesting that perfusion in the thalamus generally decreases in patients with chronic pain. Tc-99m-ECD SPECT with SPM96 may be useful for studies of the mechanisms of chronic pain. |
| doi_str_mv | 10.1007/BF02988354 |
| format | Article |
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The subjects were twelve patients with chronic pain (CP group) and twelve normal controls (NC group). After informed consent was obtained, 720 MBq of Tc-99m-ECD was intravenously injected as a bolus. The SPECT data were acquired once for 20 mins from 5 mins after i.v. injection of Tc-99m-ECD, with a triple-head rotating gamma camera. The SPECT data were transformed into a standard stereotactic space, and group comparisons between CP and NC groups were performed on a voxel-by-voxel basis. The subset of voxels exceeding a threshold of p < 0.001 in omnibus comparisons and remaining significant after correction for multiple comparison (p < 0.05) was displayed as a volume image rendered in three orthogonal projections. There was a significant decrease in perfusion in the bilateral thalami in the CP group, suggesting that perfusion in the thalamus generally decreases in patients with chronic pain. Tc-99m-ECD SPECT with SPM96 may be useful for studies of the mechanisms of chronic pain.</description><identifier>ISSN: 0914-7187</identifier><identifier>EISSN: 1864-6433</identifier><identifier>DOI: 10.1007/BF02988354</identifier><identifier>PMID: 11758955</identifier><language>eng</language><publisher>Japan: Springer Nature B.V</publisher><subject>Adult ; Algorithms ; Chronic Disease ; Chronic pain ; Cysteine - analogs & derivatives ; Data acquisition ; Female ; Humans ; Image Enhancement - methods ; Informed consent ; Male ; Mapping ; Organotechnetium Compounds ; Pain ; Pain - diagnostic imaging ; Pain - physiopathology ; Pain management ; Perfusion ; Radionuclide Imaging ; Radiopharmaceuticals ; Single photon emission computed tomography ; Statistics ; Thalamus ; Thalamus - blood supply ; Thalamus - diagnostic imaging</subject><ispartof>Annals of nuclear medicine, 2001-10, Vol.15 (5), p.459-463</ispartof><rights>Springer 2001</rights><rights>Springer 2001.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-3c3e2ee038ee4fd24defcfa48d84812e0d07a5ccfbe96769e3e3bff5262470403</citedby><cites>FETCH-LOGICAL-c454t-3c3e2ee038ee4fd24defcfa48d84812e0d07a5ccfbe96769e3e3bff5262470403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11758955$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakabeppu, Y</creatorcontrib><creatorcontrib>Nakajo, M</creatorcontrib><creatorcontrib>Gushiken, T</creatorcontrib><creatorcontrib>Tsuchimochi, S</creatorcontrib><creatorcontrib>Tani, A</creatorcontrib><creatorcontrib>Kanmura, Y</creatorcontrib><title>Decreased perfusion of the bilateral thalami in patients with chronic pain detected by Tc-99m-ECD SPECT with statistical parametric mapping</title><title>Annals of nuclear medicine</title><addtitle>Ann Nucl Med</addtitle><description>The purpose of this study was to examine whether the Tc-99m-ECD SPECT can detect any difference between the brain perfusion in patients with chronic pain and normal controls by means of the Statistical Parametric Mapping (SPM96). The subjects were twelve patients with chronic pain (CP group) and twelve normal controls (NC group). After informed consent was obtained, 720 MBq of Tc-99m-ECD was intravenously injected as a bolus. The SPECT data were acquired once for 20 mins from 5 mins after i.v. injection of Tc-99m-ECD, with a triple-head rotating gamma camera. The SPECT data were transformed into a standard stereotactic space, and group comparisons between CP and NC groups were performed on a voxel-by-voxel basis. The subset of voxels exceeding a threshold of p < 0.001 in omnibus comparisons and remaining significant after correction for multiple comparison (p < 0.05) was displayed as a volume image rendered in three orthogonal projections. There was a significant decrease in perfusion in the bilateral thalami in the CP group, suggesting that perfusion in the thalamus generally decreases in patients with chronic pain. Tc-99m-ECD SPECT with SPM96 may be useful for studies of the mechanisms of chronic pain.</description><subject>Adult</subject><subject>Algorithms</subject><subject>Chronic Disease</subject><subject>Chronic pain</subject><subject>Cysteine - analogs & derivatives</subject><subject>Data acquisition</subject><subject>Female</subject><subject>Humans</subject><subject>Image Enhancement - methods</subject><subject>Informed consent</subject><subject>Male</subject><subject>Mapping</subject><subject>Organotechnetium Compounds</subject><subject>Pain</subject><subject>Pain - diagnostic imaging</subject><subject>Pain - physiopathology</subject><subject>Pain management</subject><subject>Perfusion</subject><subject>Radionuclide Imaging</subject><subject>Radiopharmaceuticals</subject><subject>Single photon emission computed tomography</subject><subject>Statistics</subject><subject>Thalamus</subject><subject>Thalamus - blood supply</subject><subject>Thalamus - diagnostic imaging</subject><issn>0914-7187</issn><issn>1864-6433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0t1qFDEYBuAgil1rT3oBEiooCFPzO0kOdbtVoVDB7fGQyXxxU-bPJIP0GrxpU3ahULAehSTP94bAi9ApJeeUEPXx8yVhRmsuxTO0oroWVS04f45WxFBRKarVEXqV0i0hTEvNXqIjSpXURsoV-nMBLoJN0OEZol9SmEY8eZx3gNvQ2wzR9mVnezsEHEY82xxgzAn_DnmH3S5OY3DltFx1kMHlktTe4a2rjBmqzfoC__i-WW_3POUynXJwJXO20Q6QY5ke7DyH8edr9MLbPsHJYT1GN5eb7fprdXX95dv601XlhBS54o4DAyBcAwjfMdGBd94K3WmhKQPSEWWlc74FU6vaAAfeei9ZzYQigvBj9H6fO8fp1wIpN0NIDvrejjAtqTFEiFoKw4t896RUjHMmpfwvZJQyafT9228fwdtpiWP5bsOUVkzUlJmizv6pqCRCMiUK-rBHLk4pRfDNHMNg411DSXNfjOahGAW_OSQu7QDdAz00gf8FBHiyFg</recordid><startdate>20011001</startdate><enddate>20011001</enddate><creator>Nakabeppu, Y</creator><creator>Nakajo, M</creator><creator>Gushiken, T</creator><creator>Tsuchimochi, S</creator><creator>Tani, A</creator><creator>Kanmura, Y</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20011001</creationdate><title>Decreased perfusion of the bilateral thalami in patients with chronic pain detected by Tc-99m-ECD SPECT with statistical parametric mapping</title><author>Nakabeppu, Y ; Nakajo, M ; Gushiken, T ; Tsuchimochi, S ; Tani, A ; Kanmura, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-3c3e2ee038ee4fd24defcfa48d84812e0d07a5ccfbe96769e3e3bff5262470403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Algorithms</topic><topic>Chronic Disease</topic><topic>Chronic pain</topic><topic>Cysteine - analogs & derivatives</topic><topic>Data acquisition</topic><topic>Female</topic><topic>Humans</topic><topic>Image Enhancement - methods</topic><topic>Informed consent</topic><topic>Male</topic><topic>Mapping</topic><topic>Organotechnetium Compounds</topic><topic>Pain</topic><topic>Pain - diagnostic imaging</topic><topic>Pain - physiopathology</topic><topic>Pain management</topic><topic>Perfusion</topic><topic>Radionuclide Imaging</topic><topic>Radiopharmaceuticals</topic><topic>Single photon emission computed tomography</topic><topic>Statistics</topic><topic>Thalamus</topic><topic>Thalamus - blood supply</topic><topic>Thalamus - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakabeppu, Y</creatorcontrib><creatorcontrib>Nakajo, M</creatorcontrib><creatorcontrib>Gushiken, T</creatorcontrib><creatorcontrib>Tsuchimochi, S</creatorcontrib><creatorcontrib>Tani, A</creatorcontrib><creatorcontrib>Kanmura, Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>Proquest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of nuclear medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakabeppu, Y</au><au>Nakajo, M</au><au>Gushiken, T</au><au>Tsuchimochi, S</au><au>Tani, A</au><au>Kanmura, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased perfusion of the bilateral thalami in patients with chronic pain detected by Tc-99m-ECD SPECT with statistical parametric mapping</atitle><jtitle>Annals of nuclear medicine</jtitle><addtitle>Ann Nucl Med</addtitle><date>2001-10-01</date><risdate>2001</risdate><volume>15</volume><issue>5</issue><spage>459</spage><epage>463</epage><pages>459-463</pages><issn>0914-7187</issn><eissn>1864-6433</eissn><abstract>The purpose of this study was to examine whether the Tc-99m-ECD SPECT can detect any difference between the brain perfusion in patients with chronic pain and normal controls by means of the Statistical Parametric Mapping (SPM96). The subjects were twelve patients with chronic pain (CP group) and twelve normal controls (NC group). After informed consent was obtained, 720 MBq of Tc-99m-ECD was intravenously injected as a bolus. The SPECT data were acquired once for 20 mins from 5 mins after i.v. injection of Tc-99m-ECD, with a triple-head rotating gamma camera. The SPECT data were transformed into a standard stereotactic space, and group comparisons between CP and NC groups were performed on a voxel-by-voxel basis. The subset of voxels exceeding a threshold of p < 0.001 in omnibus comparisons and remaining significant after correction for multiple comparison (p < 0.05) was displayed as a volume image rendered in three orthogonal projections. There was a significant decrease in perfusion in the bilateral thalami in the CP group, suggesting that perfusion in the thalamus generally decreases in patients with chronic pain. Tc-99m-ECD SPECT with SPM96 may be useful for studies of the mechanisms of chronic pain.</abstract><cop>Japan</cop><pub>Springer Nature B.V</pub><pmid>11758955</pmid><doi>10.1007/BF02988354</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0914-7187 |
| ispartof | Annals of nuclear medicine, 2001-10, Vol.15 (5), p.459-463 |
| issn | 0914-7187 1864-6433 |
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| source | MEDLINE; SpringerNature Journals; Alma/SFX Local Collection |
| subjects | Adult Algorithms Chronic Disease Chronic pain Cysteine - analogs & derivatives Data acquisition Female Humans Image Enhancement - methods Informed consent Male Mapping Organotechnetium Compounds Pain Pain - diagnostic imaging Pain - physiopathology Pain management Perfusion Radionuclide Imaging Radiopharmaceuticals Single photon emission computed tomography Statistics Thalamus Thalamus - blood supply Thalamus - diagnostic imaging |
| title | Decreased perfusion of the bilateral thalami in patients with chronic pain detected by Tc-99m-ECD SPECT with statistical parametric mapping |
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