Association of the HindIII Polymorphism of the Lipoprotein Lipase Gene with Myocardial Infarction and the Life Span in Elderly Patients with Coronary Heart Disease

Association of the HindIII Polymorphism of the Lipoprotein Lipase Gene with Myocardial Infarction and the Life Span in Elderly Patients with Coronary Heart Disease

Allele and genotype frequencies of the HindIII polymorphism of the lipoprotein lipase (LPL) gene were studied in patients with myocardial infarction (MI) and stable angina of effort (SAE), including long-lived people (over 90). The polymorphism proved to be associated with MI and with the life span,...

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Veröffentlicht in:Molecular biology (New York) 2001-09, Vol.35 (5), p.667-670
Hauptverfasser: Malygina, N A, Melent'ev, A S, Kostomarova, I V, Melent'ev, I A, Saigitov, R T, Smirnova, Yu B, Serova, L D
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Heart attacks
Medical research
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container_issue 5
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container_title Molecular biology (New York)
container_volume 35
creator Malygina, N A
Melent'ev, A S
Kostomarova, I V
Melent'ev, I A
Saigitov, R T
Smirnova, Yu B
Serova, L D
description Allele and genotype frequencies of the HindIII polymorphism of the lipoprotein lipase (LPL) gene were studied in patients with myocardial infarction (MI) and stable angina of effort (SAE), including long-lived people (over 90). The polymorphism proved to be associated with MI and with the life span, genotype H+/H+ being predisposing to MI and allele H- being protective. The allele and genotype frequencies of long-lived people differed significantly from the Hardy-Weinberg proportions and from those of SAE patients aged up to 90. An excess of heterozygotes in this group suggests a selective pressure which eliminates homozygotes. Possibly, heterozygotes H+/H- have an adaptive advantage, which provides for their longevity.[PUBLICATION ABSTRACT]
doi_str_mv 10.1023/A:1012314018230
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subjects Heart attacks
Medical research
title Association of the HindIII Polymorphism of the Lipoprotein Lipase Gene with Myocardial Infarction and the Life Span in Elderly Patients with Coronary Heart Disease
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