Homocysteine and hypertension in persons with spinal cord injury
Study design: Cross-sectional analysis of a convenience sample of locally recruited participants, including both patients and volunteers. Objectives: To determine whether there is an association between plasma homocysteine and hypertension in persons with spinal cord injury (SCI). Setting: Spinal Co...
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| Veröffentlicht in: | Spinal cord 2006-08, Vol.44 (8), p.474-479 |
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| creator | Lee, M Y Myers, J Abella, J Froelicher, V F Perkash, I Kiratli, B J |
| description | Study design:
Cross-sectional analysis of a convenience sample of locally recruited participants, including both patients and volunteers.
Objectives:
To determine whether there is an association between plasma homocysteine and hypertension in persons with spinal cord injury (SCI).
Setting:
Spinal Cord Injury Service of the Veterans Affairs Palo Alto Medical Center (California, United States of America).
Methods:
The incidence of hypertension, dyslipidemia, insulin resistance, and the presence of metabolic syndrome were determined in 168 individuals with SCI (mean age 50.2±12.8 years). Fasting lipids, insulin, glucose, plasma homocysteine, and anthropometric data was gathered for each subject.
Results:
Blood pressure values (
P |
| doi_str_mv | 10.1038/sj.sc.3101873 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_904462670</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68716180</sourcerecordid><originalsourceid>FETCH-LOGICAL-c458t-7e9ae249f399d1dbe27e2a37e4cc2b8be44211d8116a940f4a4bfdbca64f886d3</originalsourceid><addsrcrecordid>eNp90c2L1TAQAPAgLu66evQqRVg99ZlJ8tLkpiz7BQte9BzSdOq29CXPTIu8_94sr_BAxNNkmB-TSYaxd8A3wKX5TOOGwkYCB9PIF-wCVKPrrRbqZTlLLWolrTxnr4lGzrkFa16xc9BSguTmgn25T7sUDjTjELHysaueDnvMM0YaUqyGWJWMUqTq9zA_VbQfop-qkHJXauOSD2_YWe8nwrdrvGQ_bm--X9_Xj9_uHq6_PtZBbc1cN2g9CmV7aW0HXYuiQeFlgyoE0ZoWlRIAnQHQ3ireK6_avmuD16o3Rnfykn069t3n9GtBmt1uoIDT5COmhZzlSmmhG17kx_9KbRrQYJ7hh7_gmJZc3kdOCCu1kQYKqo8o5ESUsXf7POx8Pjjg7nkDjkZHwa0bKP792nRpd9id9PrlBVytwFPwU599DAOdXBlMNNttcZujo1KKPzGfpvv3zX8ApwSd6A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>229368381</pqid></control><display><type>article</type><title>Homocysteine and hypertension in persons with spinal cord injury</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>SpringerLink Journals - AutoHoldings</source><creator>Lee, M Y ; Myers, J ; Abella, J ; Froelicher, V F ; Perkash, I ; Kiratli, B J</creator><creatorcontrib>Lee, M Y ; Myers, J ; Abella, J ; Froelicher, V F ; Perkash, I ; Kiratli, B J</creatorcontrib><description>Study design:
Cross-sectional analysis of a convenience sample of locally recruited participants, including both patients and volunteers.
Objectives:
To determine whether there is an association between plasma homocysteine and hypertension in persons with spinal cord injury (SCI).
Setting:
Spinal Cord Injury Service of the Veterans Affairs Palo Alto Medical Center (California, United States of America).
Methods:
The incidence of hypertension, dyslipidemia, insulin resistance, and the presence of metabolic syndrome were determined in 168 individuals with SCI (mean age 50.2±12.8 years). Fasting lipids, insulin, glucose, plasma homocysteine, and anthropometric data was gathered for each subject.
Results:
Blood pressure values (
P
<0.001) and mean arterial pressure (
P
<0.05) increased with higher plasma homocysteine levels. Homocysteine values were also significantly greater among individuals with hypertension compared with those who were normotensive or prehypertensive (
P
<0.0001). There was an inverse relationship between plasma homocysteine levels and glomerular filtration rate and effective renal plasma flow (
P
<0.05).
Conclusions:
Plasma homocysteine levels are elevated in persons with SCI who have hypertension and inversely related to renal function, which suggests that renal dysfunction may be a link between homocysteine and hypertension in persons with SCI.
Sponsorship:
Funded by the VA Rehabilitation Research and Development Service, Merit Review Grant #B2549R.</description><identifier>ISSN: 1362-4393</identifier><identifier>EISSN: 1476-5624</identifier><identifier>DOI: 10.1038/sj.sc.3101873</identifier><identifier>PMID: 16331308</identifier><identifier>CODEN: SPCOFM</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Age Distribution ; Anatomy ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; California - epidemiology ; Cerebrospinal fluid. Meninges. Spinal cord ; Cerebrospinal fluid. Spinal cord. Spinal roots. Spinal nerves ; Female ; Homocysteine - blood ; Human Physiology ; Humans ; Hypertension - blood ; Hypertension - epidemiology ; Incidence ; Injuries of the nervous system and the skull. Diseases due to physical agents ; Kidney Diseases - blood ; Kidney Diseases - epidemiology ; Male ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurochemistry ; Neurology ; Neuropsychology ; Neurosciences ; Neurosurgery ; original-article ; Risk Assessment - methods ; Risk Factors ; Spinal Cord Injuries - blood ; Spinal Cord Injuries - epidemiology ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Traumas. Diseases due to physical agents ; Veterans - statistics & numerical data</subject><ispartof>Spinal cord, 2006-08, Vol.44 (8), p.474-479</ispartof><rights>Springer Nature Limited 2006</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Aug 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-7e9ae249f399d1dbe27e2a37e4cc2b8be44211d8116a940f4a4bfdbca64f886d3</citedby><cites>FETCH-LOGICAL-c458t-7e9ae249f399d1dbe27e2a37e4cc2b8be44211d8116a940f4a4bfdbca64f886d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.sc.3101873$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.sc.3101873$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18032755$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16331308$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, M Y</creatorcontrib><creatorcontrib>Myers, J</creatorcontrib><creatorcontrib>Abella, J</creatorcontrib><creatorcontrib>Froelicher, V F</creatorcontrib><creatorcontrib>Perkash, I</creatorcontrib><creatorcontrib>Kiratli, B J</creatorcontrib><title>Homocysteine and hypertension in persons with spinal cord injury</title><title>Spinal cord</title><addtitle>Spinal Cord</addtitle><addtitle>Spinal Cord</addtitle><description>Study design:
Cross-sectional analysis of a convenience sample of locally recruited participants, including both patients and volunteers.
Objectives:
To determine whether there is an association between plasma homocysteine and hypertension in persons with spinal cord injury (SCI).
Setting:
Spinal Cord Injury Service of the Veterans Affairs Palo Alto Medical Center (California, United States of America).
Methods:
The incidence of hypertension, dyslipidemia, insulin resistance, and the presence of metabolic syndrome were determined in 168 individuals with SCI (mean age 50.2±12.8 years). Fasting lipids, insulin, glucose, plasma homocysteine, and anthropometric data was gathered for each subject.
Results:
Blood pressure values (
P
<0.001) and mean arterial pressure (
P
<0.05) increased with higher plasma homocysteine levels. Homocysteine values were also significantly greater among individuals with hypertension compared with those who were normotensive or prehypertensive (
P
<0.0001). There was an inverse relationship between plasma homocysteine levels and glomerular filtration rate and effective renal plasma flow (
P
<0.05).
Conclusions:
Plasma homocysteine levels are elevated in persons with SCI who have hypertension and inversely related to renal function, which suggests that renal dysfunction may be a link between homocysteine and hypertension in persons with SCI.
Sponsorship:
Funded by the VA Rehabilitation Research and Development Service, Merit Review Grant #B2549R.</description><subject>Age Distribution</subject><subject>Anatomy</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>California - epidemiology</subject><subject>Cerebrospinal fluid. Meninges. Spinal cord</subject><subject>Cerebrospinal fluid. Spinal cord. Spinal roots. Spinal nerves</subject><subject>Female</subject><subject>Homocysteine - blood</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Hypertension - blood</subject><subject>Hypertension - epidemiology</subject><subject>Incidence</subject><subject>Injuries of the nervous system and the skull. Diseases due to physical agents</subject><subject>Kidney Diseases - blood</subject><subject>Kidney Diseases - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurochemistry</subject><subject>Neurology</subject><subject>Neuropsychology</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>original-article</subject><subject>Risk Assessment - methods</subject><subject>Risk Factors</subject><subject>Spinal Cord Injuries - blood</subject><subject>Spinal Cord Injuries - epidemiology</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Traumas. Diseases due to physical agents</subject><subject>Veterans - statistics & numerical data</subject><issn>1362-4393</issn><issn>1476-5624</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp90c2L1TAQAPAgLu66evQqRVg99ZlJ8tLkpiz7BQte9BzSdOq29CXPTIu8_94sr_BAxNNkmB-TSYaxd8A3wKX5TOOGwkYCB9PIF-wCVKPrrRbqZTlLLWolrTxnr4lGzrkFa16xc9BSguTmgn25T7sUDjTjELHysaueDnvMM0YaUqyGWJWMUqTq9zA_VbQfop-qkHJXauOSD2_YWe8nwrdrvGQ_bm--X9_Xj9_uHq6_PtZBbc1cN2g9CmV7aW0HXYuiQeFlgyoE0ZoWlRIAnQHQ3ireK6_avmuD16o3Rnfykn069t3n9GtBmt1uoIDT5COmhZzlSmmhG17kx_9KbRrQYJ7hh7_gmJZc3kdOCCu1kQYKqo8o5ESUsXf7POx8Pjjg7nkDjkZHwa0bKP792nRpd9id9PrlBVytwFPwU599DAOdXBlMNNttcZujo1KKPzGfpvv3zX8ApwSd6A</recordid><startdate>20060801</startdate><enddate>20060801</enddate><creator>Lee, M Y</creator><creator>Myers, J</creator><creator>Abella, J</creator><creator>Froelicher, V F</creator><creator>Perkash, I</creator><creator>Kiratli, B J</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20060801</creationdate><title>Homocysteine and hypertension in persons with spinal cord injury</title><author>Lee, M Y ; Myers, J ; Abella, J ; Froelicher, V F ; Perkash, I ; Kiratli, B J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-7e9ae249f399d1dbe27e2a37e4cc2b8be44211d8116a940f4a4bfdbca64f886d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Age Distribution</topic><topic>Anatomy</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>California - epidemiology</topic><topic>Cerebrospinal fluid. Meninges. Spinal cord</topic><topic>Cerebrospinal fluid. Spinal cord. Spinal roots. Spinal nerves</topic><topic>Female</topic><topic>Homocysteine - blood</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Hypertension - blood</topic><topic>Hypertension - epidemiology</topic><topic>Incidence</topic><topic>Injuries of the nervous system and the skull. Diseases due to physical agents</topic><topic>Kidney Diseases - blood</topic><topic>Kidney Diseases - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurochemistry</topic><topic>Neurology</topic><topic>Neuropsychology</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>original-article</topic><topic>Risk Assessment - methods</topic><topic>Risk Factors</topic><topic>Spinal Cord Injuries - blood</topic><topic>Spinal Cord Injuries - epidemiology</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Traumas. Diseases due to physical agents</topic><topic>Veterans - statistics & numerical data</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, M Y</creatorcontrib><creatorcontrib>Myers, J</creatorcontrib><creatorcontrib>Abella, J</creatorcontrib><creatorcontrib>Froelicher, V F</creatorcontrib><creatorcontrib>Perkash, I</creatorcontrib><creatorcontrib>Kiratli, B J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Spinal cord</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, M Y</au><au>Myers, J</au><au>Abella, J</au><au>Froelicher, V F</au><au>Perkash, I</au><au>Kiratli, B J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Homocysteine and hypertension in persons with spinal cord injury</atitle><jtitle>Spinal cord</jtitle><stitle>Spinal Cord</stitle><addtitle>Spinal Cord</addtitle><date>2006-08-01</date><risdate>2006</risdate><volume>44</volume><issue>8</issue><spage>474</spage><epage>479</epage><pages>474-479</pages><issn>1362-4393</issn><eissn>1476-5624</eissn><coden>SPCOFM</coden><abstract>Study design:
Cross-sectional analysis of a convenience sample of locally recruited participants, including both patients and volunteers.
Objectives:
To determine whether there is an association between plasma homocysteine and hypertension in persons with spinal cord injury (SCI).
Setting:
Spinal Cord Injury Service of the Veterans Affairs Palo Alto Medical Center (California, United States of America).
Methods:
The incidence of hypertension, dyslipidemia, insulin resistance, and the presence of metabolic syndrome were determined in 168 individuals with SCI (mean age 50.2±12.8 years). Fasting lipids, insulin, glucose, plasma homocysteine, and anthropometric data was gathered for each subject.
Results:
Blood pressure values (
P
<0.001) and mean arterial pressure (
P
<0.05) increased with higher plasma homocysteine levels. Homocysteine values were also significantly greater among individuals with hypertension compared with those who were normotensive or prehypertensive (
P
<0.0001). There was an inverse relationship between plasma homocysteine levels and glomerular filtration rate and effective renal plasma flow (
P
<0.05).
Conclusions:
Plasma homocysteine levels are elevated in persons with SCI who have hypertension and inversely related to renal function, which suggests that renal dysfunction may be a link between homocysteine and hypertension in persons with SCI.
Sponsorship:
Funded by the VA Rehabilitation Research and Development Service, Merit Review Grant #B2549R.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>16331308</pmid><doi>10.1038/sj.sc.3101873</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Spinal cord, 2006-08, Vol.44 (8), p.474-479 |
| issn | 1362-4393 1476-5624 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerLink Journals - AutoHoldings |
| subjects | Age Distribution Anatomy Biological and medical sciences Biomedical and Life Sciences Biomedicine California - epidemiology Cerebrospinal fluid. Meninges. Spinal cord Cerebrospinal fluid. Spinal cord. Spinal roots. Spinal nerves Female Homocysteine - blood Human Physiology Humans Hypertension - blood Hypertension - epidemiology Incidence Injuries of the nervous system and the skull. Diseases due to physical agents Kidney Diseases - blood Kidney Diseases - epidemiology Male Medical sciences Nervous system (semeiology, syndromes) Neurochemistry Neurology Neuropsychology Neurosciences Neurosurgery original-article Risk Assessment - methods Risk Factors Spinal Cord Injuries - blood Spinal Cord Injuries - epidemiology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Traumas. Diseases due to physical agents Veterans - statistics & numerical data |
| title | Homocysteine and hypertension in persons with spinal cord injury |
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