Invasive neonatal GBS infections from an area-based surveillance study in Italy
During an area-based study, 75 group B streptococcus (GBS) strains isolated both from early-onset disease (EOD, 37 strains) and from late-onset disease (LOD, 38 strains) were analysed for serotype, pulsed field gel electrophoresis (PFGE) and multilocus sequence typing profiles, protein markers and a...
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description | During an area-based study, 75 group B streptococcus (GBS) strains isolated both from early-onset disease (EOD, 37 strains) and from late-onset disease (LOD, 38 strains) were analysed for serotype, pulsed field gel electrophoresis (PFGE) and multilocus sequence typing profiles, protein markers and antibiotic resistance. Serotype III, possessing the rib gene, was the most frequent (54 strains, 72%) and responsible for 89.5% and 54% of LOD and EOD, respectively. Forty-six serotype III strains belonged to the same PFGE type and clonal complex 17, already described as an over-represented clone in neonatal invasive GBS infections. Other serotypes were Ia (9.3%), II (6.7%), Ib (5.3%), V (5.3%) and IV (1.3%). Seventeen PFGE groups were identified comprising strains with related sequence types; conversely, strains displaying the same sequence type could belong to different PFGE groups. When both neonate and maternal strains from vaginorectal swabs and/or milk were available (eight cases), they were indistinguishable. Resistance to erythromycin (12%) was associated with a constitutive resistance to clindamycin in five cases (four carrying the erm(B) gene and one both the erm(B) and mef(E) genes) and with an inducible clindamycin resistance in two cases (one possessing the erm(A) gene, the other the erm(T) gene). Two isolates displayed the M phenotype (mef(E) gene). All strains but five were resistant to tetracycline, mostly mediated by the tet(M) gene (97.1%). The study underlined the importance of an active surveillance system for the elucidation of a GBS population structure causing neonatal infections and allowed the detection of rare antibiotic resistance determinants [erm(T)]. |
doi_str_mv | 10.1111/j.1469-0691.2011.03479.x |
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Serotype III, possessing the rib gene, was the most frequent (54 strains, 72%) and responsible for 89.5% and 54% of LOD and EOD, respectively. Forty-six serotype III strains belonged to the same PFGE type and clonal complex 17, already described as an over-represented clone in neonatal invasive GBS infections. Other serotypes were Ia (9.3%), II (6.7%), Ib (5.3%), V (5.3%) and IV (1.3%). Seventeen PFGE groups were identified comprising strains with related sequence types; conversely, strains displaying the same sequence type could belong to different PFGE groups. When both neonate and maternal strains from vaginorectal swabs and/or milk were available (eight cases), they were indistinguishable. Resistance to erythromycin (12%) was associated with a constitutive resistance to clindamycin in five cases (four carrying the erm(B) gene and one both the erm(B) and mef(E) genes) and with an inducible clindamycin resistance in two cases (one possessing the erm(A) gene, the other the erm(T) gene). Two isolates displayed the M phenotype (mef(E) gene). All strains but five were resistant to tetracycline, mostly mediated by the tet(M) gene (97.1%). The study underlined the importance of an active surveillance system for the elucidation of a GBS population structure causing neonatal infections and allowed the detection of rare antibiotic resistance determinants [erm(T)].</description><identifier>ISSN: 1198-743X</identifier><identifier>EISSN: 1469-0691</identifier><identifier>DOI: 10.1111/j.1469-0691.2011.03479.x</identifier><identifier>PMID: 21722258</identifier><language>eng</language><publisher>Oxford, UK: Elsevier Ltd</publisher><subject>Alpha-like protein family ; Anti-Bacterial Agents - pharmacology ; Antibacterial agents ; antibiotic resistance ; Antibiotics ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Bacterial diseases ; Bacterial Proteins - analysis ; Bacterial Proteins - genetics ; Bacteriology ; Biological and medical sciences ; Clindamycin - pharmacology ; Cluster Analysis ; DNA Fingerprinting ; DNA, Bacterial - genetics ; Drug Resistance, Bacterial ; Electrophoresis, Gel, Pulsed-Field ; Erythromycin - pharmacology ; Genotype ; group B streptococcus ; Human bacterial diseases ; Humans ; Infant ; Infant, Newborn ; Infections ; Infectious diseases ; Italy - epidemiology ; Medical sciences ; Microbial Sensitivity Tests ; MLST ; Molecular Epidemiology ; Multilocus Sequence Typing ; neonatal infection ; PFGE ; Pharmacology. Drug treatments ; Phenotype ; Proteome - analysis ; S. agalactiae ; S. agalactiae ; serotype ; Serotyping ; Staphylococcal infections, streptococcal infections, pneumococcal infections ; Streptococcal Infections - epidemiology ; Streptococcal Infections - microbiology ; Streptococcal Infections - pathology ; Streptococcus agalactiae - classification ; Streptococcus agalactiae - genetics ; Streptococcus agalactiae - immunology ; Streptococcus agalactiae - isolation & purification ; Tetracycline - pharmacology</subject><ispartof>Clinical microbiology and infection, 2011-12, Vol.17 (12), p.1834-1839</ispartof><rights>2011 European Society of Clinical Infectious Diseases</rights><rights>2011 The Authors. Clinical Microbiology and Infection © 2011 European Society of Clinical Microbiology and Infectious Diseases</rights><rights>2015 INIST-CNRS</rights><rights>2011 The Authors. Clinical Microbiology and Infection © 2011 European Society of Clinical Microbiology and Infectious Diseases.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6019-fb723aeb5a08efad3cb41be95e602eaafddcb9e2d979a8d451b70cf55bfdb72b3</citedby><cites>FETCH-LOGICAL-c6019-fb723aeb5a08efad3cb41be95e602eaafddcb9e2d979a8d451b70cf55bfdb72b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1469-0691.2011.03479.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1469-0691.2011.03479.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24766002$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21722258$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Imperi, M.</creatorcontrib><creatorcontrib>Gherardi, G.</creatorcontrib><creatorcontrib>Berardi, A.</creatorcontrib><creatorcontrib>Baldassarri, L.</creatorcontrib><creatorcontrib>Pataracchia, M.</creatorcontrib><creatorcontrib>Dicuonzo, G.</creatorcontrib><creatorcontrib>Orefici, G.</creatorcontrib><creatorcontrib>Creti, R.</creatorcontrib><title>Invasive neonatal GBS infections from an area-based surveillance study in Italy</title><title>Clinical microbiology and infection</title><addtitle>Clin Microbiol Infect</addtitle><description>During an area-based study, 75 group B streptococcus (GBS) strains isolated both from early-onset disease (EOD, 37 strains) and from late-onset disease (LOD, 38 strains) were analysed for serotype, pulsed field gel electrophoresis (PFGE) and multilocus sequence typing profiles, protein markers and antibiotic resistance. Serotype III, possessing the rib gene, was the most frequent (54 strains, 72%) and responsible for 89.5% and 54% of LOD and EOD, respectively. Forty-six serotype III strains belonged to the same PFGE type and clonal complex 17, already described as an over-represented clone in neonatal invasive GBS infections. Other serotypes were Ia (9.3%), II (6.7%), Ib (5.3%), V (5.3%) and IV (1.3%). Seventeen PFGE groups were identified comprising strains with related sequence types; conversely, strains displaying the same sequence type could belong to different PFGE groups. When both neonate and maternal strains from vaginorectal swabs and/or milk were available (eight cases), they were indistinguishable. Resistance to erythromycin (12%) was associated with a constitutive resistance to clindamycin in five cases (four carrying the erm(B) gene and one both the erm(B) and mef(E) genes) and with an inducible clindamycin resistance in two cases (one possessing the erm(A) gene, the other the erm(T) gene). Two isolates displayed the M phenotype (mef(E) gene). All strains but five were resistant to tetracycline, mostly mediated by the tet(M) gene (97.1%). The study underlined the importance of an active surveillance system for the elucidation of a GBS population structure causing neonatal infections and allowed the detection of rare antibiotic resistance determinants [erm(T)].</description><subject>Alpha-like protein family</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>antibiotic resistance</subject><subject>Antibiotics</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Bacterial diseases</subject><subject>Bacterial Proteins - analysis</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Clindamycin - pharmacology</subject><subject>Cluster Analysis</subject><subject>DNA Fingerprinting</subject><subject>DNA, Bacterial - genetics</subject><subject>Drug Resistance, Bacterial</subject><subject>Electrophoresis, Gel, Pulsed-Field</subject><subject>Erythromycin - pharmacology</subject><subject>Genotype</subject><subject>group B streptococcus</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Italy - epidemiology</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>MLST</subject><subject>Molecular Epidemiology</subject><subject>Multilocus Sequence Typing</subject><subject>neonatal infection</subject><subject>PFGE</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenotype</subject><subject>Proteome - analysis</subject><subject>S. agalactiae</subject><subject>S. agalactiae</subject><subject>serotype</subject><subject>Serotyping</subject><subject>Staphylococcal infections, streptococcal infections, pneumococcal infections</subject><subject>Streptococcal Infections - epidemiology</subject><subject>Streptococcal Infections - microbiology</subject><subject>Streptococcal Infections - pathology</subject><subject>Streptococcus agalactiae - classification</subject><subject>Streptococcus agalactiae - genetics</subject><subject>Streptococcus agalactiae - immunology</subject><subject>Streptococcus agalactiae - isolation & purification</subject><subject>Tetracycline - pharmacology</subject><issn>1198-743X</issn><issn>1469-0691</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1vEzEQhi1ERUvgLyBLCHHaxfZ6P3zgQCMokVL1UJC4WWN7LDna7BY7mzb_Hi8JReJCffFIfl57_AwhlLOS5_VhU3LZqII1ipeCcV6ySraqfHhGLh4Pnueaq65oZfXjnLxMacMYE1UlX5BzwVshRN1dkJvVsIcU9kgHHAfYQU-vLm9pGDzaXRiHRH0ctxQGChGhMJDQ0TTFPYa-h8EiTbvJHXKArnL48IqceegTvj7tC_L9y-dvy6_F-uZqtfy0LmzDuCq8aUUFaGpgHXpwlTWSG1Q1NkwggHfOGoXCqVZB52TNTcusr2vjXY6aakHeH--9i-PPCdNOb0OyOPeE45S0YlIIyUWdybf_kJtxikNuTvNa1qpqO95lqjtSNo4pRfT6LoYtxIPmTM_O9UbPavWsVs_O9W_n-iFH35wemMwW3WPwj-QMvDsBkCz0PmZvIf3lZNs082gW5OORuw89Hp7cgF6ur-cq5y-Peczi9wGjTjZgnpELMU9TuzH8_ze_AGzMso0</recordid><startdate>201112</startdate><enddate>201112</enddate><creator>Imperi, M.</creator><creator>Gherardi, G.</creator><creator>Berardi, A.</creator><creator>Baldassarri, L.</creator><creator>Pataracchia, M.</creator><creator>Dicuonzo, G.</creator><creator>Orefici, G.</creator><creator>Creti, R.</creator><general>Elsevier Ltd</general><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>201112</creationdate><title>Invasive neonatal GBS infections from an area-based surveillance study in Italy</title><author>Imperi, M. ; Gherardi, G. ; Berardi, A. ; Baldassarri, L. ; Pataracchia, M. ; Dicuonzo, G. ; Orefici, G. ; Creti, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6019-fb723aeb5a08efad3cb41be95e602eaafddcb9e2d979a8d451b70cf55bfdb72b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Alpha-like protein family</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial agents</topic><topic>antibiotic resistance</topic><topic>Antibiotics</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Bacterial diseases</topic><topic>Bacterial Proteins - analysis</topic><topic>Bacterial Proteins - genetics</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Clindamycin - pharmacology</topic><topic>Cluster Analysis</topic><topic>DNA Fingerprinting</topic><topic>DNA, Bacterial - genetics</topic><topic>Drug Resistance, Bacterial</topic><topic>Electrophoresis, Gel, Pulsed-Field</topic><topic>Erythromycin - pharmacology</topic><topic>Genotype</topic><topic>group B streptococcus</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Italy - epidemiology</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>MLST</topic><topic>Molecular Epidemiology</topic><topic>Multilocus Sequence Typing</topic><topic>neonatal infection</topic><topic>PFGE</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenotype</topic><topic>Proteome - analysis</topic><topic>S. agalactiae</topic><topic>S. agalactiae</topic><topic>serotype</topic><topic>Serotyping</topic><topic>Staphylococcal infections, streptococcal infections, pneumococcal infections</topic><topic>Streptococcal Infections - epidemiology</topic><topic>Streptococcal Infections - microbiology</topic><topic>Streptococcal Infections - pathology</topic><topic>Streptococcus agalactiae - classification</topic><topic>Streptococcus agalactiae - genetics</topic><topic>Streptococcus agalactiae - immunology</topic><topic>Streptococcus agalactiae - isolation & purification</topic><topic>Tetracycline - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Imperi, M.</creatorcontrib><creatorcontrib>Gherardi, G.</creatorcontrib><creatorcontrib>Berardi, A.</creatorcontrib><creatorcontrib>Baldassarri, L.</creatorcontrib><creatorcontrib>Pataracchia, M.</creatorcontrib><creatorcontrib>Dicuonzo, G.</creatorcontrib><creatorcontrib>Orefici, G.</creatorcontrib><creatorcontrib>Creti, R.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical microbiology and infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Imperi, M.</au><au>Gherardi, G.</au><au>Berardi, A.</au><au>Baldassarri, L.</au><au>Pataracchia, M.</au><au>Dicuonzo, G.</au><au>Orefici, G.</au><au>Creti, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Invasive neonatal GBS infections from an area-based surveillance study in Italy</atitle><jtitle>Clinical microbiology and infection</jtitle><addtitle>Clin Microbiol Infect</addtitle><date>2011-12</date><risdate>2011</risdate><volume>17</volume><issue>12</issue><spage>1834</spage><epage>1839</epage><pages>1834-1839</pages><issn>1198-743X</issn><eissn>1469-0691</eissn><abstract>During an area-based study, 75 group B streptococcus (GBS) strains isolated both from early-onset disease (EOD, 37 strains) and from late-onset disease (LOD, 38 strains) were analysed for serotype, pulsed field gel electrophoresis (PFGE) and multilocus sequence typing profiles, protein markers and antibiotic resistance. Serotype III, possessing the rib gene, was the most frequent (54 strains, 72%) and responsible for 89.5% and 54% of LOD and EOD, respectively. Forty-six serotype III strains belonged to the same PFGE type and clonal complex 17, already described as an over-represented clone in neonatal invasive GBS infections. Other serotypes were Ia (9.3%), II (6.7%), Ib (5.3%), V (5.3%) and IV (1.3%). Seventeen PFGE groups were identified comprising strains with related sequence types; conversely, strains displaying the same sequence type could belong to different PFGE groups. When both neonate and maternal strains from vaginorectal swabs and/or milk were available (eight cases), they were indistinguishable. Resistance to erythromycin (12%) was associated with a constitutive resistance to clindamycin in five cases (four carrying the erm(B) gene and one both the erm(B) and mef(E) genes) and with an inducible clindamycin resistance in two cases (one possessing the erm(A) gene, the other the erm(T) gene). Two isolates displayed the M phenotype (mef(E) gene). All strains but five were resistant to tetracycline, mostly mediated by the tet(M) gene (97.1%). The study underlined the importance of an active surveillance system for the elucidation of a GBS population structure causing neonatal infections and allowed the detection of rare antibiotic resistance determinants [erm(T)].</abstract><cop>Oxford, UK</cop><pub>Elsevier Ltd</pub><pmid>21722258</pmid><doi>10.1111/j.1469-0691.2011.03479.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Alpha-like protein family Anti-Bacterial Agents - pharmacology Antibacterial agents antibiotic resistance Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial diseases Bacterial Proteins - analysis Bacterial Proteins - genetics Bacteriology Biological and medical sciences Clindamycin - pharmacology Cluster Analysis DNA Fingerprinting DNA, Bacterial - genetics Drug Resistance, Bacterial Electrophoresis, Gel, Pulsed-Field Erythromycin - pharmacology Genotype group B streptococcus Human bacterial diseases Humans Infant Infant, Newborn Infections Infectious diseases Italy - epidemiology Medical sciences Microbial Sensitivity Tests MLST Molecular Epidemiology Multilocus Sequence Typing neonatal infection PFGE Pharmacology. Drug treatments Phenotype Proteome - analysis S. agalactiae S. agalactiae serotype Serotyping Staphylococcal infections, streptococcal infections, pneumococcal infections Streptococcal Infections - epidemiology Streptococcal Infections - microbiology Streptococcal Infections - pathology Streptococcus agalactiae - classification Streptococcus agalactiae - genetics Streptococcus agalactiae - immunology Streptococcus agalactiae - isolation & purification Tetracycline - pharmacology |
title | Invasive neonatal GBS infections from an area-based surveillance study in Italy |
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