Invasive neonatal GBS infections from an area-based surveillance study in Italy

During an area-based study, 75 group B streptococcus (GBS) strains isolated both from early-onset disease (EOD, 37 strains) and from late-onset disease (LOD, 38 strains) were analysed for serotype, pulsed field gel electrophoresis (PFGE) and multilocus sequence typing profiles, protein markers and a...

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Veröffentlicht in:Clinical microbiology and infection 2011-12, Vol.17 (12), p.1834-1839
Hauptverfasser: Imperi, M., Gherardi, G., Berardi, A., Baldassarri, L., Pataracchia, M., Dicuonzo, G., Orefici, G., Creti, R.
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container_end_page 1839
container_issue 12
container_start_page 1834
container_title Clinical microbiology and infection
container_volume 17
creator Imperi, M.
Gherardi, G.
Berardi, A.
Baldassarri, L.
Pataracchia, M.
Dicuonzo, G.
Orefici, G.
Creti, R.
description During an area-based study, 75 group B streptococcus (GBS) strains isolated both from early-onset disease (EOD, 37 strains) and from late-onset disease (LOD, 38 strains) were analysed for serotype, pulsed field gel electrophoresis (PFGE) and multilocus sequence typing profiles, protein markers and antibiotic resistance. Serotype III, possessing the rib gene, was the most frequent (54 strains, 72%) and responsible for 89.5% and 54% of LOD and EOD, respectively. Forty-six serotype III strains belonged to the same PFGE type and clonal complex 17, already described as an over-represented clone in neonatal invasive GBS infections. Other serotypes were Ia (9.3%), II (6.7%), Ib (5.3%), V (5.3%) and IV (1.3%). Seventeen PFGE groups were identified comprising strains with related sequence types; conversely, strains displaying the same sequence type could belong to different PFGE groups. When both neonate and maternal strains from vaginorectal swabs and/or milk were available (eight cases), they were indistinguishable. Resistance to erythromycin (12%) was associated with a constitutive resistance to clindamycin in five cases (four carrying the erm(B) gene and one both the erm(B) and mef(E) genes) and with an inducible clindamycin resistance in two cases (one possessing the erm(A) gene, the other the erm(T) gene). Two isolates displayed the M phenotype (mef(E) gene). All strains but five were resistant to tetracycline, mostly mediated by the tet(M) gene (97.1%). The study underlined the importance of an active surveillance system for the elucidation of a GBS population structure causing neonatal infections and allowed the detection of rare antibiotic resistance determinants [erm(T)].
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Resistance to erythromycin (12%) was associated with a constitutive resistance to clindamycin in five cases (four carrying the erm(B) gene and one both the erm(B) and mef(E) genes) and with an inducible clindamycin resistance in two cases (one possessing the erm(A) gene, the other the erm(T) gene). Two isolates displayed the M phenotype (mef(E) gene). All strains but five were resistant to tetracycline, mostly mediated by the tet(M) gene (97.1%). 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Drug treatments ; Phenotype ; Proteome - analysis ; S. agalactiae ; S. agalactiae ; serotype ; Serotyping ; Staphylococcal infections, streptococcal infections, pneumococcal infections ; Streptococcal Infections - epidemiology ; Streptococcal Infections - microbiology ; Streptococcal Infections - pathology ; Streptococcus agalactiae - classification ; Streptococcus agalactiae - genetics ; Streptococcus agalactiae - immunology ; Streptococcus agalactiae - isolation &amp; purification ; Tetracycline - pharmacology</subject><ispartof>Clinical microbiology and infection, 2011-12, Vol.17 (12), p.1834-1839</ispartof><rights>2011 European Society of Clinical Infectious Diseases</rights><rights>2011 The Authors. Clinical Microbiology and Infection © 2011 European Society of Clinical Microbiology and Infectious Diseases</rights><rights>2015 INIST-CNRS</rights><rights>2011 The Authors. 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Serotype III, possessing the rib gene, was the most frequent (54 strains, 72%) and responsible for 89.5% and 54% of LOD and EOD, respectively. Forty-six serotype III strains belonged to the same PFGE type and clonal complex 17, already described as an over-represented clone in neonatal invasive GBS infections. Other serotypes were Ia (9.3%), II (6.7%), Ib (5.3%), V (5.3%) and IV (1.3%). Seventeen PFGE groups were identified comprising strains with related sequence types; conversely, strains displaying the same sequence type could belong to different PFGE groups. When both neonate and maternal strains from vaginorectal swabs and/or milk were available (eight cases), they were indistinguishable. Resistance to erythromycin (12%) was associated with a constitutive resistance to clindamycin in five cases (four carrying the erm(B) gene and one both the erm(B) and mef(E) genes) and with an inducible clindamycin resistance in two cases (one possessing the erm(A) gene, the other the erm(T) gene). Two isolates displayed the M phenotype (mef(E) gene). All strains but five were resistant to tetracycline, mostly mediated by the tet(M) gene (97.1%). The study underlined the importance of an active surveillance system for the elucidation of a GBS population structure causing neonatal infections and allowed the detection of rare antibiotic resistance determinants [erm(T)].</description><subject>Alpha-like protein family</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>antibiotic resistance</subject><subject>Antibiotics</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Bacterial diseases</subject><subject>Bacterial Proteins - analysis</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Clindamycin - pharmacology</subject><subject>Cluster Analysis</subject><subject>DNA Fingerprinting</subject><subject>DNA, Bacterial - genetics</subject><subject>Drug Resistance, Bacterial</subject><subject>Electrophoresis, Gel, Pulsed-Field</subject><subject>Erythromycin - pharmacology</subject><subject>Genotype</subject><subject>group B streptococcus</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Italy - epidemiology</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>MLST</subject><subject>Molecular Epidemiology</subject><subject>Multilocus Sequence Typing</subject><subject>neonatal infection</subject><subject>PFGE</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenotype</subject><subject>Proteome - analysis</subject><subject>S. agalactiae</subject><subject>S. agalactiae</subject><subject>serotype</subject><subject>Serotyping</subject><subject>Staphylococcal infections, streptococcal infections, pneumococcal infections</subject><subject>Streptococcal Infections - epidemiology</subject><subject>Streptococcal Infections - microbiology</subject><subject>Streptococcal Infections - pathology</subject><subject>Streptococcus agalactiae - classification</subject><subject>Streptococcus agalactiae - genetics</subject><subject>Streptococcus agalactiae - immunology</subject><subject>Streptococcus agalactiae - isolation &amp; purification</subject><subject>Tetracycline - pharmacology</subject><issn>1198-743X</issn><issn>1469-0691</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1vEzEQhi1ERUvgLyBLCHHaxfZ6P3zgQCMokVL1UJC4WWN7LDna7BY7mzb_Hi8JReJCffFIfl57_AwhlLOS5_VhU3LZqII1ipeCcV6ySraqfHhGLh4Pnueaq65oZfXjnLxMacMYE1UlX5BzwVshRN1dkJvVsIcU9kgHHAfYQU-vLm9pGDzaXRiHRH0ctxQGChGhMJDQ0TTFPYa-h8EiTbvJHXKArnL48IqceegTvj7tC_L9y-dvy6_F-uZqtfy0LmzDuCq8aUUFaGpgHXpwlTWSG1Q1NkwggHfOGoXCqVZB52TNTcusr2vjXY6aakHeH--9i-PPCdNOb0OyOPeE45S0YlIIyUWdybf_kJtxikNuTvNa1qpqO95lqjtSNo4pRfT6LoYtxIPmTM_O9UbPavWsVs_O9W_n-iFH35wemMwW3WPwj-QMvDsBkCz0PmZvIf3lZNs082gW5OORuw89Hp7cgF6ur-cq5y-Peczi9wGjTjZgnpELMU9TuzH8_ze_AGzMso0</recordid><startdate>201112</startdate><enddate>201112</enddate><creator>Imperi, M.</creator><creator>Gherardi, G.</creator><creator>Berardi, A.</creator><creator>Baldassarri, L.</creator><creator>Pataracchia, M.</creator><creator>Dicuonzo, G.</creator><creator>Orefici, G.</creator><creator>Creti, R.</creator><general>Elsevier Ltd</general><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>201112</creationdate><title>Invasive neonatal GBS infections from an area-based surveillance study in Italy</title><author>Imperi, M. ; Gherardi, G. ; Berardi, A. ; Baldassarri, L. ; Pataracchia, M. ; Dicuonzo, G. ; Orefici, G. ; Creti, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6019-fb723aeb5a08efad3cb41be95e602eaafddcb9e2d979a8d451b70cf55bfdb72b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Alpha-like protein family</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial agents</topic><topic>antibiotic resistance</topic><topic>Antibiotics</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Bacterial diseases</topic><topic>Bacterial Proteins - analysis</topic><topic>Bacterial Proteins - genetics</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Clindamycin - pharmacology</topic><topic>Cluster Analysis</topic><topic>DNA Fingerprinting</topic><topic>DNA, Bacterial - genetics</topic><topic>Drug Resistance, Bacterial</topic><topic>Electrophoresis, Gel, Pulsed-Field</topic><topic>Erythromycin - pharmacology</topic><topic>Genotype</topic><topic>group B streptococcus</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Italy - epidemiology</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>MLST</topic><topic>Molecular Epidemiology</topic><topic>Multilocus Sequence Typing</topic><topic>neonatal infection</topic><topic>PFGE</topic><topic>Pharmacology. 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Resistance to erythromycin (12%) was associated with a constitutive resistance to clindamycin in five cases (four carrying the erm(B) gene and one both the erm(B) and mef(E) genes) and with an inducible clindamycin resistance in two cases (one possessing the erm(A) gene, the other the erm(T) gene). Two isolates displayed the M phenotype (mef(E) gene). All strains but five were resistant to tetracycline, mostly mediated by the tet(M) gene (97.1%). The study underlined the importance of an active surveillance system for the elucidation of a GBS population structure causing neonatal infections and allowed the detection of rare antibiotic resistance determinants [erm(T)].</abstract><cop>Oxford, UK</cop><pub>Elsevier Ltd</pub><pmid>21722258</pmid><doi>10.1111/j.1469-0691.2011.03479.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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subjects Alpha-like protein family
Anti-Bacterial Agents - pharmacology
Antibacterial agents
antibiotic resistance
Antibiotics
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial diseases
Bacterial Proteins - analysis
Bacterial Proteins - genetics
Bacteriology
Biological and medical sciences
Clindamycin - pharmacology
Cluster Analysis
DNA Fingerprinting
DNA, Bacterial - genetics
Drug Resistance, Bacterial
Electrophoresis, Gel, Pulsed-Field
Erythromycin - pharmacology
Genotype
group B streptococcus
Human bacterial diseases
Humans
Infant
Infant, Newborn
Infections
Infectious diseases
Italy - epidemiology
Medical sciences
Microbial Sensitivity Tests
MLST
Molecular Epidemiology
Multilocus Sequence Typing
neonatal infection
PFGE
Pharmacology. Drug treatments
Phenotype
Proteome - analysis
S. agalactiae
S. agalactiae
serotype
Serotyping
Staphylococcal infections, streptococcal infections, pneumococcal infections
Streptococcal Infections - epidemiology
Streptococcal Infections - microbiology
Streptococcal Infections - pathology
Streptococcus agalactiae - classification
Streptococcus agalactiae - genetics
Streptococcus agalactiae - immunology
Streptococcus agalactiae - isolation & purification
Tetracycline - pharmacology
title Invasive neonatal GBS infections from an area-based surveillance study in Italy
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