Prostatic acid phosphatase is expressed in human prostate cancer bone metastases and promotes osteoblast differentiation

Prostate cancer (PCa) bone metastases are a major cause of morbidity and mortality. There are no effective therapies for PCa bone metastases that prolong survival. Prostatic acid phosphatase (PAP) is a secretory protein expressed by PCa cells. We demonstrate that PAP is strongly expressed in PCa bon...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2011-11, Vol.1237 (1), p.64-70
Hauptverfasser:	Kirschenbaum, Alexander, Liu, Xin-Hua, Yao, Shen, Leiter, Amanda, Levine, Alice C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Phosphatase Animals Biocompatibility Biomedical materials bone metastases Bone Neoplasms - enzymology Bone Neoplasms - pathology Bone Neoplasms - secondary Bones Cancer Cell Differentiation - physiology Cell Line, Tumor Differentiation Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Human Humans Male Mentoring programs Metastasis Mice Mortality osteoblasts Osteoblasts - enzymology Osteoblasts - pathology Osteogenesis - physiology Phosphatase Prostate Prostate cancer Prostate-Specific Antigen - biosynthesis prostatic acid phosphatase Prostatic Neoplasms - enzymology Prostatic Neoplasms - pathology Protein Tyrosine Phosphatases - biosynthesis
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