Use of alcohol-free antimicrobial mouth rinse is associated with decreased incidence of preterm birth in a high-risk population
Objective We sought to determine if treatment of periodontal disease during pregnancy with an alcohol-free antimicrobial mouth rinse containing cetylpyridinium chloride impacts the incidence of preterm birth (PTB) in a high-risk population. Study Design This single-blind clinical trial studied pregn...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2011-10, Vol.205 (4), p.382.e1-382.e6 |
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| container_end_page | 382.e6 |
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| container_issue | 4 |
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| container_title | American journal of obstetrics and gynecology |
| container_volume | 205 |
| creator | Jeffcoat, Marjorie, DMD Parry, Samuel, MD Gerlach, Robert W., DDS Doyle, Matthew J., PhD |
| description | Objective We sought to determine if treatment of periodontal disease during pregnancy with an alcohol-free antimicrobial mouth rinse containing cetylpyridinium chloride impacts the incidence of preterm birth (PTB) in a high-risk population. Study Design This single-blind clinical trial studied pregnant women (6-20 weeks' gestation) with periodontal disease who refused dental care. Subjects receiving mouth rinse were compared to designated controls who did not receive rinse (1 rinse:2 controls), balanced on prior PTB and smoking. Primary outcome was PTB |
| doi_str_mv | 10.1016/j.ajog.2011.07.016 |
| format | Article |
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Study Design This single-blind clinical trial studied pregnant women (6-20 weeks' gestation) with periodontal disease who refused dental care. Subjects receiving mouth rinse were compared to designated controls who did not receive rinse (1 rinse:2 controls), balanced on prior PTB and smoking. Primary outcome was PTB <35 weeks. Results In all, 226 women were included in the analysis (71 mouth rinse subjects, 155 controls). Incidence of PTB <35 weeks was lower in the rinse group compared to controls (5.6% and 21.9% respectively, P < .01); relative risk was 0.26 (95% confidence interval, 0.096–0.70). Gestational age and birthweight were significantly higher in the rinse group ( P < .01). Conclusion A nonalcohol antimicrobial mouth rinse containing cetylpyridinium chloride was associated with decreased incidence of PTB <35 weeks.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/j.ajog.2011.07.016</identifier><identifier>PMID: 22083060</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Anti-Infective Agents - administration & dosage ; Biological and medical sciences ; clinical study ; Diseases of mother, fetus and pregnancy ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Incidence ; intervention ; Medical sciences ; Mouthwashes - therapeutic use ; Obstetrics and Gynecology ; periodontal disease ; Periodontal Diseases - complications ; Periodontal Diseases - drug therapy ; Pregnancy ; Pregnancy. Fetus. Placenta ; Premature Birth - epidemiology ; Premature Birth - etiology ; Premature Birth - prevention & control ; preterm birth ; Risk Factors ; Single-Blind Method ; Young Adult</subject><ispartof>American journal of obstetrics and gynecology, 2011-10, Vol.205 (4), p.382.e1-382.e6</ispartof><rights>Mosby, Inc.</rights><rights>2011 Mosby, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Mosby, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-8735c96f0c7b413a62835c7ac25ce36e689c770971d3908c1d2ddb588404089b3</citedby><cites>FETCH-LOGICAL-c440t-8735c96f0c7b413a62835c7ac25ce36e689c770971d3908c1d2ddb588404089b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ajog.2011.07.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3548,23928,23929,25138,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25281244$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22083060$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeffcoat, Marjorie, DMD</creatorcontrib><creatorcontrib>Parry, Samuel, MD</creatorcontrib><creatorcontrib>Gerlach, Robert W., DDS</creatorcontrib><creatorcontrib>Doyle, Matthew J., PhD</creatorcontrib><title>Use of alcohol-free antimicrobial mouth rinse is associated with decreased incidence of preterm birth in a high-risk population</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Objective We sought to determine if treatment of periodontal disease during pregnancy with an alcohol-free antimicrobial mouth rinse containing cetylpyridinium chloride impacts the incidence of preterm birth (PTB) in a high-risk population. Study Design This single-blind clinical trial studied pregnant women (6-20 weeks' gestation) with periodontal disease who refused dental care. Subjects receiving mouth rinse were compared to designated controls who did not receive rinse (1 rinse:2 controls), balanced on prior PTB and smoking. Primary outcome was PTB <35 weeks. Results In all, 226 women were included in the analysis (71 mouth rinse subjects, 155 controls). Incidence of PTB <35 weeks was lower in the rinse group compared to controls (5.6% and 21.9% respectively, P < .01); relative risk was 0.26 (95% confidence interval, 0.096–0.70). Gestational age and birthweight were significantly higher in the rinse group ( P < .01). Conclusion A nonalcohol antimicrobial mouth rinse containing cetylpyridinium chloride was associated with decreased incidence of PTB <35 weeks.</description><subject>Adult</subject><subject>Anti-Infective Agents - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>clinical study</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Incidence</subject><subject>intervention</subject><subject>Medical sciences</subject><subject>Mouthwashes - therapeutic use</subject><subject>Obstetrics and Gynecology</subject><subject>periodontal disease</subject><subject>Periodontal Diseases - complications</subject><subject>Periodontal Diseases - drug therapy</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Premature Birth - epidemiology</subject><subject>Premature Birth - etiology</subject><subject>Premature Birth - prevention & control</subject><subject>preterm birth</subject><subject>Risk Factors</subject><subject>Single-Blind Method</subject><subject>Young Adult</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ks-L1TAQgIso7tvVf8CD5CKeWidJf6QggiyuCgsedM8hTab75m3b1KRV9uS_bup7KnjwFGbyzSTzMVn2jEPBgdevDoU5-NtCAOcFNEVKPch2HNomr1WtHmY7ABB5Kxt1lp3HeNhC0YrH2ZkQoCTUsMt-3ERkvmdmsH7vh7wPiMxMC41kg-_IDGz067JngaZEUmQmRm_JLOjYd0oXDm1AE1NIkyWHk_3VcA64YBhZRyFBNDHD9nS7zwPFOzb7eR3MQn56kj3qzRDx6em8yG6u3n25_JBff3r_8fLtdW7LEpZcNbKybd2DbbqSS1MLlRKNsaKyKGusVWubJo3OnWxBWe6Ec12lVAklqLaTF9nLY985-K8rxkWPFC0Og5nQr1G3UAohq1olUhzJNH-MAXs9BxpNuNcc9OZdH_TmXW_eNTQ6pVLR81P7tRvR_Sn5LToBL06AidYMfTBJVvzLVUJxUZaJe33kMMn4Rhh0tLQ5dRTQLtp5-v8_3vxTbgeaKL14h_cYD34NU9KsuY5Cg_68rcS2IJwDtLyR8ieLEbZn</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Jeffcoat, Marjorie, DMD</creator><creator>Parry, Samuel, MD</creator><creator>Gerlach, Robert W., DDS</creator><creator>Doyle, Matthew J., PhD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111001</creationdate><title>Use of alcohol-free antimicrobial mouth rinse is associated with decreased incidence of preterm birth in a high-risk population</title><author>Jeffcoat, Marjorie, DMD ; Parry, Samuel, MD ; Gerlach, Robert W., DDS ; Doyle, Matthew J., PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-8735c96f0c7b413a62835c7ac25ce36e689c770971d3908c1d2ddb588404089b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Anti-Infective Agents - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>clinical study</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Incidence</topic><topic>intervention</topic><topic>Medical sciences</topic><topic>Mouthwashes - therapeutic use</topic><topic>Obstetrics and Gynecology</topic><topic>periodontal disease</topic><topic>Periodontal Diseases - complications</topic><topic>Periodontal Diseases - drug therapy</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Premature Birth - epidemiology</topic><topic>Premature Birth - etiology</topic><topic>Premature Birth - prevention & control</topic><topic>preterm birth</topic><topic>Risk Factors</topic><topic>Single-Blind Method</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeffcoat, Marjorie, DMD</creatorcontrib><creatorcontrib>Parry, Samuel, MD</creatorcontrib><creatorcontrib>Gerlach, Robert W., DDS</creatorcontrib><creatorcontrib>Doyle, Matthew J., PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeffcoat, Marjorie, DMD</au><au>Parry, Samuel, MD</au><au>Gerlach, Robert W., DDS</au><au>Doyle, Matthew J., PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of alcohol-free antimicrobial mouth rinse is associated with decreased incidence of preterm birth in a high-risk population</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>205</volume><issue>4</issue><spage>382.e1</spage><epage>382.e6</epage><pages>382.e1-382.e6</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Objective We sought to determine if treatment of periodontal disease during pregnancy with an alcohol-free antimicrobial mouth rinse containing cetylpyridinium chloride impacts the incidence of preterm birth (PTB) in a high-risk population. Study Design This single-blind clinical trial studied pregnant women (6-20 weeks' gestation) with periodontal disease who refused dental care. Subjects receiving mouth rinse were compared to designated controls who did not receive rinse (1 rinse:2 controls), balanced on prior PTB and smoking. Primary outcome was PTB <35 weeks. Results In all, 226 women were included in the analysis (71 mouth rinse subjects, 155 controls). Incidence of PTB <35 weeks was lower in the rinse group compared to controls (5.6% and 21.9% respectively, P < .01); relative risk was 0.26 (95% confidence interval, 0.096–0.70). Gestational age and birthweight were significantly higher in the rinse group ( P < .01). Conclusion A nonalcohol antimicrobial mouth rinse containing cetylpyridinium chloride was associated with decreased incidence of PTB <35 weeks.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>22083060</pmid><doi>10.1016/j.ajog.2011.07.016</doi><tpages>2</tpages></addata></record> |
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| subjects | Adult Anti-Infective Agents - administration & dosage Biological and medical sciences clinical study Diseases of mother, fetus and pregnancy Female Gynecology. Andrology. Obstetrics Humans Incidence intervention Medical sciences Mouthwashes - therapeutic use Obstetrics and Gynecology periodontal disease Periodontal Diseases - complications Periodontal Diseases - drug therapy Pregnancy Pregnancy. Fetus. Placenta Premature Birth - epidemiology Premature Birth - etiology Premature Birth - prevention & control preterm birth Risk Factors Single-Blind Method Young Adult |
| title | Use of alcohol-free antimicrobial mouth rinse is associated with decreased incidence of preterm birth in a high-risk population |
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