Uncertain etiologies of proteinuric-chronic kidney disease in rural Sri Lanka
The global prevalence of chronic kidney disease (CKD) of uncertain etiology may be underreported. Community-level epidemiological studies are few due to the lack of national registries and poor focus on the reporting of non-communicable diseases. Here we describe the prevalence of proteinuric-CKD an...
Gespeichert in:
| Veröffentlicht in: | Kidney international 2011-12, Vol.80 (11), p.1212-1221 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1221 |
|---|---|
| container_issue | 11 |
| container_start_page | 1212 |
| container_title | Kidney international |
| container_volume | 80 |
| creator | Athuraliya, Nimmi T.C. Abeysekera, Tilak D.J. Amerasinghe, Priyanie H. Kumarasiri, Ranjit Bandara, Palitha Karunaratne, Upul Milton, Abul H. Jones, Alison L. |
| description | The global prevalence of chronic kidney disease (CKD) of uncertain etiology may be underreported. Community-level epidemiological studies are few due to the lack of national registries and poor focus on the reporting of non-communicable diseases. Here we describe the prevalence of proteinuric-CKD and disease characteristics of three rural populations in the North Central, Central, and Southern Provinces of Sri Lanka. Patients were selected using the random cluster sampling method and those older than 19 years of age were screened for persistent dipstick proteinuria. The prevalence of proteinuric-CKD in the Medawachchiya region (North Central) was 130 of 2600 patients, 68 of 709 patients in the Yatinuwara region (Central), and 66 of 2844 patients in the Hambantota region (Southern). The mean ages of these patients with CKD ranged from 44 to 52 years. Diabetes and long-standing hypertension were the main risk factors of CKD in the Yatinuwara and Hambantota regions. Age, exceeding 60 years, and farming were strongly associated with proteinuric-CKD in the Medawachchiya region; however, major risk factors were uncertain in 87% of these patients. Of these patients, 26 underwent renal biopsy; histology indicated tubulointerstitial disease. Thus, proteinuric-CKD of uncertain etiology is prevalent in the North Central Province of Sri Lanka. In contrast, known risk factors were associated with CKD in the Central and Southern Provinces. |
| doi_str_mv | 10.1038/ki.2011.258 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_904223315</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0085253815549727</els_id><sourcerecordid>904223315</sourcerecordid><originalsourceid>FETCH-LOGICAL-c518t-388667cd3890f8b8fd1d689ab2132880164ddff5dea42ca0aa4d048d25f4a7e43</originalsourceid><addsrcrecordid>eNpt0UuLFDEUBeAgitMzunKvhTC4kGrzrEotZfAFLS501iGd3Oidqk7GpEqYf2-aakcQVyHw5d7DCSHPGN0yKvSbEbecMrblSj8gG6a4aFmv1EOyoVSrliuhz8h5KTe03gdBH5MzzrTgg-Yb8vk6OsizxdjAjGlK3xFKk0Jzm9MMGJeMrnU_coromhF9hLvGYwFboKlv8pLt1HzN2OxsHO0T8ijYqcDT03lBrt-_-3b1sd19-fDp6u2udYrpuRVad13vvNADDXqvg2e-04Pdcya41pR10vsQlAcrubPUWump1J6rIG0PUlyQV-vcmvLnAmU2BywOpslGSEsxA5WcC8FUlS__kTdpybGGq0jojnaUVfR6RS6nUjIEc5vxYPOdYdQcOzYjmmPHpnZc9fPTyGV_AH9v_5RaweUJ2OLsFLKNDstfJ3tJ-66r7sXqop2XDPdgxOOudZVaBdQyfyFkUxxC_TGPGdxsfML_RvwNxSmfpQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>903860601</pqid></control><display><type>article</type><title>Uncertain etiologies of proteinuric-chronic kidney disease in rural Sri Lanka</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>ProQuest Central UK/Ireland</source><source>Alma/SFX Local Collection</source><creator>Athuraliya, Nimmi T.C. ; Abeysekera, Tilak D.J. ; Amerasinghe, Priyanie H. ; Kumarasiri, Ranjit ; Bandara, Palitha ; Karunaratne, Upul ; Milton, Abul H. ; Jones, Alison L.</creator><creatorcontrib>Athuraliya, Nimmi T.C. ; Abeysekera, Tilak D.J. ; Amerasinghe, Priyanie H. ; Kumarasiri, Ranjit ; Bandara, Palitha ; Karunaratne, Upul ; Milton, Abul H. ; Jones, Alison L.</creatorcontrib><description>The global prevalence of chronic kidney disease (CKD) of uncertain etiology may be underreported. Community-level epidemiological studies are few due to the lack of national registries and poor focus on the reporting of non-communicable diseases. Here we describe the prevalence of proteinuric-CKD and disease characteristics of three rural populations in the North Central, Central, and Southern Provinces of Sri Lanka. Patients were selected using the random cluster sampling method and those older than 19 years of age were screened for persistent dipstick proteinuria. The prevalence of proteinuric-CKD in the Medawachchiya region (North Central) was 130 of 2600 patients, 68 of 709 patients in the Yatinuwara region (Central), and 66 of 2844 patients in the Hambantota region (Southern). The mean ages of these patients with CKD ranged from 44 to 52 years. Diabetes and long-standing hypertension were the main risk factors of CKD in the Yatinuwara and Hambantota regions. Age, exceeding 60 years, and farming were strongly associated with proteinuric-CKD in the Medawachchiya region; however, major risk factors were uncertain in 87% of these patients. Of these patients, 26 underwent renal biopsy; histology indicated tubulointerstitial disease. Thus, proteinuric-CKD of uncertain etiology is prevalent in the North Central Province of Sri Lanka. In contrast, known risk factors were associated with CKD in the Central and Southern Provinces.</description><identifier>ISSN: 0085-2538</identifier><identifier>EISSN: 1523-1755</identifier><identifier>DOI: 10.1038/ki.2011.258</identifier><identifier>PMID: 21832982</identifier><identifier>CODEN: KDYIA5</identifier><language>eng</language><publisher>Basingstoke: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; chronic kidney disease ; Humans ; Kidneys ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Prevalence ; proteinuria ; Proteinuria - epidemiology ; Proteinuria - etiology ; Renal Insufficiency, Chronic - epidemiology ; Renal Insufficiency, Chronic - etiology ; Risk Factors ; Rural Health - statistics & numerical data ; Sri Lanka - epidemiology ; uncertain etiology ; Urinary system involvement in other diseases. Miscellaneous ; Urinary tract. Prostate gland ; Young Adult</subject><ispartof>Kidney international, 2011-12, Vol.80 (11), p.1212-1221</ispartof><rights>2011 International Society of Nephrology</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Dec 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-388667cd3890f8b8fd1d689ab2132880164ddff5dea42ca0aa4d048d25f4a7e43</citedby><cites>FETCH-LOGICAL-c518t-388667cd3890f8b8fd1d689ab2132880164ddff5dea42ca0aa4d048d25f4a7e43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/903860601?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24740766$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21832982$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Athuraliya, Nimmi T.C.</creatorcontrib><creatorcontrib>Abeysekera, Tilak D.J.</creatorcontrib><creatorcontrib>Amerasinghe, Priyanie H.</creatorcontrib><creatorcontrib>Kumarasiri, Ranjit</creatorcontrib><creatorcontrib>Bandara, Palitha</creatorcontrib><creatorcontrib>Karunaratne, Upul</creatorcontrib><creatorcontrib>Milton, Abul H.</creatorcontrib><creatorcontrib>Jones, Alison L.</creatorcontrib><title>Uncertain etiologies of proteinuric-chronic kidney disease in rural Sri Lanka</title><title>Kidney international</title><addtitle>Kidney Int</addtitle><description>The global prevalence of chronic kidney disease (CKD) of uncertain etiology may be underreported. Community-level epidemiological studies are few due to the lack of national registries and poor focus on the reporting of non-communicable diseases. Here we describe the prevalence of proteinuric-CKD and disease characteristics of three rural populations in the North Central, Central, and Southern Provinces of Sri Lanka. Patients were selected using the random cluster sampling method and those older than 19 years of age were screened for persistent dipstick proteinuria. The prevalence of proteinuric-CKD in the Medawachchiya region (North Central) was 130 of 2600 patients, 68 of 709 patients in the Yatinuwara region (Central), and 66 of 2844 patients in the Hambantota region (Southern). The mean ages of these patients with CKD ranged from 44 to 52 years. Diabetes and long-standing hypertension were the main risk factors of CKD in the Yatinuwara and Hambantota regions. Age, exceeding 60 years, and farming were strongly associated with proteinuric-CKD in the Medawachchiya region; however, major risk factors were uncertain in 87% of these patients. Of these patients, 26 underwent renal biopsy; histology indicated tubulointerstitial disease. Thus, proteinuric-CKD of uncertain etiology is prevalent in the North Central Province of Sri Lanka. In contrast, known risk factors were associated with CKD in the Central and Southern Provinces.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>chronic kidney disease</subject><subject>Humans</subject><subject>Kidneys</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Prevalence</subject><subject>proteinuria</subject><subject>Proteinuria - epidemiology</subject><subject>Proteinuria - etiology</subject><subject>Renal Insufficiency, Chronic - epidemiology</subject><subject>Renal Insufficiency, Chronic - etiology</subject><subject>Risk Factors</subject><subject>Rural Health - statistics & numerical data</subject><subject>Sri Lanka - epidemiology</subject><subject>uncertain etiology</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>Urinary tract. Prostate gland</subject><subject>Young Adult</subject><issn>0085-2538</issn><issn>1523-1755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpt0UuLFDEUBeAgitMzunKvhTC4kGrzrEotZfAFLS501iGd3Oidqk7GpEqYf2-aakcQVyHw5d7DCSHPGN0yKvSbEbecMrblSj8gG6a4aFmv1EOyoVSrliuhz8h5KTe03gdBH5MzzrTgg-Yb8vk6OsizxdjAjGlK3xFKk0Jzm9MMGJeMrnU_coromhF9hLvGYwFboKlv8pLt1HzN2OxsHO0T8ijYqcDT03lBrt-_-3b1sd19-fDp6u2udYrpuRVad13vvNADDXqvg2e-04Pdcya41pR10vsQlAcrubPUWump1J6rIG0PUlyQV-vcmvLnAmU2BywOpslGSEsxA5WcC8FUlS__kTdpybGGq0jojnaUVfR6RS6nUjIEc5vxYPOdYdQcOzYjmmPHpnZc9fPTyGV_AH9v_5RaweUJ2OLsFLKNDstfJ3tJ-66r7sXqop2XDPdgxOOudZVaBdQyfyFkUxxC_TGPGdxsfML_RvwNxSmfpQ</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>Athuraliya, Nimmi T.C.</creator><creator>Abeysekera, Tilak D.J.</creator><creator>Amerasinghe, Priyanie H.</creator><creator>Kumarasiri, Ranjit</creator><creator>Bandara, Palitha</creator><creator>Karunaratne, Upul</creator><creator>Milton, Abul H.</creator><creator>Jones, Alison L.</creator><general>Elsevier Inc</general><general>Nature Publishing Group</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20111201</creationdate><title>Uncertain etiologies of proteinuric-chronic kidney disease in rural Sri Lanka</title><author>Athuraliya, Nimmi T.C. ; Abeysekera, Tilak D.J. ; Amerasinghe, Priyanie H. ; Kumarasiri, Ranjit ; Bandara, Palitha ; Karunaratne, Upul ; Milton, Abul H. ; Jones, Alison L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c518t-388667cd3890f8b8fd1d689ab2132880164ddff5dea42ca0aa4d048d25f4a7e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>chronic kidney disease</topic><topic>Humans</topic><topic>Kidneys</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Prevalence</topic><topic>proteinuria</topic><topic>Proteinuria - epidemiology</topic><topic>Proteinuria - etiology</topic><topic>Renal Insufficiency, Chronic - epidemiology</topic><topic>Renal Insufficiency, Chronic - etiology</topic><topic>Risk Factors</topic><topic>Rural Health - statistics & numerical data</topic><topic>Sri Lanka - epidemiology</topic><topic>uncertain etiology</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><topic>Urinary tract. Prostate gland</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Athuraliya, Nimmi T.C.</creatorcontrib><creatorcontrib>Abeysekera, Tilak D.J.</creatorcontrib><creatorcontrib>Amerasinghe, Priyanie H.</creatorcontrib><creatorcontrib>Kumarasiri, Ranjit</creatorcontrib><creatorcontrib>Bandara, Palitha</creatorcontrib><creatorcontrib>Karunaratne, Upul</creatorcontrib><creatorcontrib>Milton, Abul H.</creatorcontrib><creatorcontrib>Jones, Alison L.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Kidney international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Athuraliya, Nimmi T.C.</au><au>Abeysekera, Tilak D.J.</au><au>Amerasinghe, Priyanie H.</au><au>Kumarasiri, Ranjit</au><au>Bandara, Palitha</au><au>Karunaratne, Upul</au><au>Milton, Abul H.</au><au>Jones, Alison L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Uncertain etiologies of proteinuric-chronic kidney disease in rural Sri Lanka</atitle><jtitle>Kidney international</jtitle><addtitle>Kidney Int</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>80</volume><issue>11</issue><spage>1212</spage><epage>1221</epage><pages>1212-1221</pages><issn>0085-2538</issn><eissn>1523-1755</eissn><coden>KDYIA5</coden><abstract>The global prevalence of chronic kidney disease (CKD) of uncertain etiology may be underreported. Community-level epidemiological studies are few due to the lack of national registries and poor focus on the reporting of non-communicable diseases. Here we describe the prevalence of proteinuric-CKD and disease characteristics of three rural populations in the North Central, Central, and Southern Provinces of Sri Lanka. Patients were selected using the random cluster sampling method and those older than 19 years of age were screened for persistent dipstick proteinuria. The prevalence of proteinuric-CKD in the Medawachchiya region (North Central) was 130 of 2600 patients, 68 of 709 patients in the Yatinuwara region (Central), and 66 of 2844 patients in the Hambantota region (Southern). The mean ages of these patients with CKD ranged from 44 to 52 years. Diabetes and long-standing hypertension were the main risk factors of CKD in the Yatinuwara and Hambantota regions. Age, exceeding 60 years, and farming were strongly associated with proteinuric-CKD in the Medawachchiya region; however, major risk factors were uncertain in 87% of these patients. Of these patients, 26 underwent renal biopsy; histology indicated tubulointerstitial disease. Thus, proteinuric-CKD of uncertain etiology is prevalent in the North Central Province of Sri Lanka. In contrast, known risk factors were associated with CKD in the Central and Southern Provinces.</abstract><cop>Basingstoke</cop><pub>Elsevier Inc</pub><pmid>21832982</pmid><doi>10.1038/ki.2011.258</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0085-2538 |
| ispartof | Kidney international, 2011-12, Vol.80 (11), p.1212-1221 |
| issn | 0085-2538 1523-1755 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_904223315 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; Alma/SFX Local Collection |
| subjects | Adult Biological and medical sciences chronic kidney disease Humans Kidneys Medical sciences Middle Aged Nephrology. Urinary tract diseases Prevalence proteinuria Proteinuria - epidemiology Proteinuria - etiology Renal Insufficiency, Chronic - epidemiology Renal Insufficiency, Chronic - etiology Risk Factors Rural Health - statistics & numerical data Sri Lanka - epidemiology uncertain etiology Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland Young Adult |
| title | Uncertain etiologies of proteinuric-chronic kidney disease in rural Sri Lanka |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T08%3A20%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Uncertain%20etiologies%20of%20proteinuric-chronic%20kidney%20disease%20in%20rural%20Sri%20Lanka&rft.jtitle=Kidney%20international&rft.au=Athuraliya,%20Nimmi%20T.C.&rft.date=2011-12-01&rft.volume=80&rft.issue=11&rft.spage=1212&rft.epage=1221&rft.pages=1212-1221&rft.issn=0085-2538&rft.eissn=1523-1755&rft.coden=KDYIA5&rft_id=info:doi/10.1038/ki.2011.258&rft_dat=%3Cproquest_cross%3E904223315%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=903860601&rft_id=info:pmid/21832982&rft_els_id=S0085253815549727&rfr_iscdi=true |