Migration of MDA-MB-231 breast cancer cells depends on the availability of exogenous lipids and cholesterol esterification

We previously described a lipid-accumulating phenotype of estrogen receptor negative (ER − ) breast cancer cells exemplified by the MDA-MB-231 and MDA-MB-436 cell lines. These cells had more lipid droplets, a higher uptake of oleic acid and LDL, a higher ratio of cholesteryl ester (CE) to triacylgly...

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Veröffentlicht in:	Clinical & experimental metastasis 2011-12, Vol.28 (8), p.733-741
Hauptverfasser:	Antalis, Caryl J., Uchida, Aki, Buhman, Kimberly K., Siddiqui, Rafat A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyl-CoA C-Acetyltransferase - genetics Acetyl-CoA C-Acetyltransferase - metabolism Biomedical and Life Sciences Biomedicine Blotting, Western Breast - metabolism Breast - pathology Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Research Cell Movement Cells, Cultured Chemotaxis Cholesterol - metabolism Esterification Female Hematology Humans Lipid Metabolism Oncology Real-Time Polymerase Chain Reaction Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Receptors, LDL - genetics Receptors, LDL - metabolism Research Paper RNA, Messenger - genetics Surgical Oncology
Online-Zugang:	Volltext
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