Decline in βhCG levels between days 0 and 4 after a single dose of methotrexate for ectopic pregnancy predicts treatment success: a retrospective cohort study
Please cite this paper as: Skubisz M, Lee J, Wallace E, Tong S. Decline in βhCG levels between days 0 and 4 after a single dose of methotrexate for ectopic pregnancy predicts treatment success: a retrospective cohort study. BJOG 2011;118:1665–1668. In current protocols for the medical management of...
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| Veröffentlicht in: | BJOG : an international journal of obstetrics and gynaecology 2011-12, Vol.118 (13), p.1665-1668 |
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| container_title | BJOG : an international journal of obstetrics and gynaecology |
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| creator | Skubisz, MM Lee, J Wallace, EM Tong, S |
| description | Please cite this paper as: Skubisz M, Lee J, Wallace E, Tong S. Decline in βhCG levels between days 0 and 4 after a single dose of methotrexate for ectopic pregnancy predicts treatment success: a retrospective cohort study. BJOG 2011;118:1665–1668.
In current protocols for the medical management of ectopic pregnancies, the first indication of treatment response is obtained no sooner than day 7. We examined whether human chorionic gonadotrophin (βhCG) trends between days 0 and 4 after methotrexate provide an earlier indication of the likely outcome. Of 33 patients where serum βhCG dropped between days 0 and 4 after methotrexate, the ectopic pregnancy was resolved in 88% of cases without further treatment. Of 12 women where serum βhCG rose between days 0 and 4, only 42% had treatment success. A fall in βhCG between days 0 and 4 after treatment with methotrexate for ectopic pregnancy predicts a high likelihood of treatment success. |
| doi_str_mv | 10.1111/j.1471-0528.2011.03133.x |
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In current protocols for the medical management of ectopic pregnancies, the first indication of treatment response is obtained no sooner than day 7. We examined whether human chorionic gonadotrophin (βhCG) trends between days 0 and 4 after methotrexate provide an earlier indication of the likely outcome. Of 33 patients where serum βhCG dropped between days 0 and 4 after methotrexate, the ectopic pregnancy was resolved in 88% of cases without further treatment. Of 12 women where serum βhCG rose between days 0 and 4, only 42% had treatment success. A fall in βhCG between days 0 and 4 after treatment with methotrexate for ectopic pregnancy predicts a high likelihood of treatment success.</description><identifier>ISSN: 1470-0328</identifier><identifier>EISSN: 1471-0528</identifier><identifier>DOI: 10.1111/j.1471-0528.2011.03133.x</identifier><identifier>PMID: 21895960</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Abortifacient Agents, Nonsteroidal - administration & dosage ; Biological and medical sciences ; Biomarker ; Biomarkers - metabolism ; Bones, joints and connective tissue. Antiinflammatory agents ; Chorionic Gonadotropin, beta Subunit, Human - metabolism ; Diseases of mother, fetus and pregnancy ; ectopic pregnancy ; Female ; Gynecology. Andrology. Obstetrics ; human chorionic gonadotrophin ; Humans ; medical management ; Medical sciences ; methotrexate ; Methotrexate - administration & dosage ; Pharmacology. Drug treatments ; Pregnancy ; Pregnancy, Ectopic - drug therapy ; Pregnancy, Ectopic - metabolism ; Pregnancy. Fetus. Placenta ; Retrospective Studies ; Time Factors ; Treatment Outcome</subject><ispartof>BJOG : an international journal of obstetrics and gynaecology, 2011-12, Vol.118 (13), p.1665-1668</ispartof><rights>2011 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2011 RCOG</rights><rights>2015 INIST-CNRS</rights><rights>2011 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2011 RCOG.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3143-465153cd3162717a5497e5941455e68c1b58b4008678ba3ab4146a76ed6406c33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-0528.2011.03133.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-0528.2011.03133.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24757159$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21895960$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Skubisz, MM</creatorcontrib><creatorcontrib>Lee, J</creatorcontrib><creatorcontrib>Wallace, EM</creatorcontrib><creatorcontrib>Tong, S</creatorcontrib><title>Decline in βhCG levels between days 0 and 4 after a single dose of methotrexate for ectopic pregnancy predicts treatment success: a retrospective cohort study</title><title>BJOG : an international journal of obstetrics and gynaecology</title><addtitle>BJOG</addtitle><description>Please cite this paper as: Skubisz M, Lee J, Wallace E, Tong S. Decline in βhCG levels between days 0 and 4 after a single dose of methotrexate for ectopic pregnancy predicts treatment success: a retrospective cohort study. BJOG 2011;118:1665–1668.
In current protocols for the medical management of ectopic pregnancies, the first indication of treatment response is obtained no sooner than day 7. We examined whether human chorionic gonadotrophin (βhCG) trends between days 0 and 4 after methotrexate provide an earlier indication of the likely outcome. Of 33 patients where serum βhCG dropped between days 0 and 4 after methotrexate, the ectopic pregnancy was resolved in 88% of cases without further treatment. Of 12 women where serum βhCG rose between days 0 and 4, only 42% had treatment success. A fall in βhCG between days 0 and 4 after treatment with methotrexate for ectopic pregnancy predicts a high likelihood of treatment success.</description><subject>Abortifacient Agents, Nonsteroidal - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Biomarker</subject><subject>Biomarkers - metabolism</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Chorionic Gonadotropin, beta Subunit, Human - metabolism</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>ectopic pregnancy</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>human chorionic gonadotrophin</subject><subject>Humans</subject><subject>medical management</subject><subject>Medical sciences</subject><subject>methotrexate</subject><subject>Methotrexate - administration & dosage</subject><subject>Pharmacology. Drug treatments</subject><subject>Pregnancy</subject><subject>Pregnancy, Ectopic - drug therapy</subject><subject>Pregnancy, Ectopic - metabolism</subject><subject>Pregnancy. Fetus. 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Antiinflammatory agents</topic><topic>Chorionic Gonadotropin, beta Subunit, Human - metabolism</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>ectopic pregnancy</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>human chorionic gonadotrophin</topic><topic>Humans</topic><topic>medical management</topic><topic>Medical sciences</topic><topic>methotrexate</topic><topic>Methotrexate - administration & dosage</topic><topic>Pharmacology. Drug treatments</topic><topic>Pregnancy</topic><topic>Pregnancy, Ectopic - drug therapy</topic><topic>Pregnancy, Ectopic - metabolism</topic><topic>Pregnancy. Fetus. 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Decline in βhCG levels between days 0 and 4 after a single dose of methotrexate for ectopic pregnancy predicts treatment success: a retrospective cohort study. BJOG 2011;118:1665–1668.
In current protocols for the medical management of ectopic pregnancies, the first indication of treatment response is obtained no sooner than day 7. We examined whether human chorionic gonadotrophin (βhCG) trends between days 0 and 4 after methotrexate provide an earlier indication of the likely outcome. Of 33 patients where serum βhCG dropped between days 0 and 4 after methotrexate, the ectopic pregnancy was resolved in 88% of cases without further treatment. Of 12 women where serum βhCG rose between days 0 and 4, only 42% had treatment success. A fall in βhCG between days 0 and 4 after treatment with methotrexate for ectopic pregnancy predicts a high likelihood of treatment success.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21895960</pmid><doi>10.1111/j.1471-0528.2011.03133.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Abortifacient Agents, Nonsteroidal - administration & dosage Biological and medical sciences Biomarker Biomarkers - metabolism Bones, joints and connective tissue. Antiinflammatory agents Chorionic Gonadotropin, beta Subunit, Human - metabolism Diseases of mother, fetus and pregnancy ectopic pregnancy Female Gynecology. Andrology. Obstetrics human chorionic gonadotrophin Humans medical management Medical sciences methotrexate Methotrexate - administration & dosage Pharmacology. Drug treatments Pregnancy Pregnancy, Ectopic - drug therapy Pregnancy, Ectopic - metabolism Pregnancy. Fetus. Placenta Retrospective Studies Time Factors Treatment Outcome |
| title | Decline in βhCG levels between days 0 and 4 after a single dose of methotrexate for ectopic pregnancy predicts treatment success: a retrospective cohort study |
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