Solvent-free, microwave assisted Knoevenagel condensation of novel 2,5-disubstituted indole analogues and their biological evaluation

A rapid, efficient and environmental benign methodology for the preparation of 2,5-disubstituted indole analogues is developed. 2,5-Disubstituted indole-3-carboxaldehydes ( 1a– c) undergo Knoevenagel condensation with barbiturates ( 2 & 4), thiazolidine-2,4-dione ( 6) and 3-methyl-1 H-pyrazol-5(...

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Veröffentlicht in:	European journal of medicinal chemistry 2011-12, Vol.46 (12), p.6112-6118
Hauptverfasser:	Biradar, J.S., Sasidhar, B.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	2,5-disubstituted indole-3-carboxaldehydes Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antioxidant activity Antioxidants - chemical synthesis Antioxidants - chemistry Antioxidants - pharmacology Biological and medical sciences Cell Line, Tumor Chemistry Techniques, Synthetic - economics Chemistry Techniques, Synthetic - methods Cytotoxic activity General aspects Humans Indoles - chemical synthesis Indoles - chemistry Indoles - pharmacology Knoevenagel condensation Medical sciences Microwave irradiation Microwaves Neoplasms - drug therapy Pharmacology. Drug treatments
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