The Sterile 20-like Kinase Tao-1 Controls Tissue Growth by Regulating the Salvador-Warts-Hippo Pathway
The Salvador-Warts-Hippo (SWH) pathway is a complex signaling network that controls both developmental and regenerative tissue growth. Using a genetic screen in Drosophila melanogaster, we identified the sterile 20-like kinase, Tao-1, as an SWH pathway member. Tao-1 controls various biological pheno...
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| Veröffentlicht in: | Developmental cell 2011-11, Vol.21 (5), p.896-906 |
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| creator | Poon, Carole L.C. Lin, Jane I. Zhang, Xiaomeng Harvey, Kieran F. |
| description | The Salvador-Warts-Hippo (SWH) pathway is a complex signaling network that controls both developmental and regenerative tissue growth. Using a genetic screen in Drosophila melanogaster, we identified the sterile 20-like kinase, Tao-1, as an SWH pathway member. Tao-1 controls various biological phenomena, including microtubule dynamics, animal behavior, and brain development. Here we describe a role for Tao-1 as a regulator of epithelial tissue growth that modulates activity of the core SWH pathway kinase cassette. Tao-1 functions together with Hippo to activate Warts-mediated repression of Yorkie. Tao-1's ability to control SWH pathway activity is evolutionarily conserved because human TAO1 can suppress activity of the Yorkie ortholog, YAP. Human TAO1 controls SWH pathway activity by phosphorylating, and activating, the Hippo ortholog, MST2. Given that SWH pathway activity is subverted in many human cancers, our findings identify human TAO kinases as potential tumor suppressor genes.
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► Tao-1 kinase regulates the growth of developing epithelial tissues in Drosophila ► Tao-1 regulates SWH pathway activity in both Drosophila and human cultured cells ► Tao-1 functions together with Hippo to activate Warts and suppress Yorkie ► Human TAO1 can phosphorylate and activate human MST2 |
| doi_str_mv | 10.1016/j.devcel.2011.09.012 |
| format | Article |
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► Tao-1 kinase regulates the growth of developing epithelial tissues in Drosophila ► Tao-1 regulates SWH pathway activity in both Drosophila and human cultured cells ► Tao-1 functions together with Hippo to activate Warts and suppress Yorkie ► Human TAO1 can phosphorylate and activate human MST2</description><identifier>ISSN: 1534-5807</identifier><identifier>EISSN: 1878-1551</identifier><identifier>DOI: 10.1016/j.devcel.2011.09.012</identifier><identifier>PMID: 22075148</identifier><language>eng</language><publisher>Cambridge, MA: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Cell Cycle Proteins - metabolism ; Cell differentiation, maturation, development, hematopoiesis ; Cell Line ; Cell physiology ; Conserved Sequence ; Drosophila melanogaster - enzymology ; Drosophila melanogaster - growth & development ; Drosophila melanogaster - metabolism ; Drosophila Proteins - metabolism ; Epithelium - growth & development ; Epithelium - metabolism ; Eye - growth & development ; Female ; Fundamental and applied biological sciences. Psychology ; Human viral diseases ; Humans ; Infectious diseases ; Intracellular Signaling Peptides and Proteins - metabolism ; MAP Kinase Kinase Kinases - metabolism ; Medical sciences ; Molecular and cellular biology ; Nuclear Proteins - metabolism ; Protein Kinases - metabolism ; Protein-Serine-Threonine Kinases - metabolism ; Signal Transduction ; Trans-Activators - metabolism ; Transcription Factors - metabolism ; Viral diseases ; Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye ; Wings, Animal - growth & development</subject><ispartof>Developmental cell, 2011-11, Vol.21 (5), p.896-906</ispartof><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-9b2d5d01af893d5fbe28454db6fc071d388595bcd3949cc29c3993b6d33f130a3</citedby><cites>FETCH-LOGICAL-c437t-9b2d5d01af893d5fbe28454db6fc071d388595bcd3949cc29c3993b6d33f130a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1534580711004102$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25229734$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22075148$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Poon, Carole L.C.</creatorcontrib><creatorcontrib>Lin, Jane I.</creatorcontrib><creatorcontrib>Zhang, Xiaomeng</creatorcontrib><creatorcontrib>Harvey, Kieran F.</creatorcontrib><title>The Sterile 20-like Kinase Tao-1 Controls Tissue Growth by Regulating the Salvador-Warts-Hippo Pathway</title><title>Developmental cell</title><addtitle>Dev Cell</addtitle><description>The Salvador-Warts-Hippo (SWH) pathway is a complex signaling network that controls both developmental and regenerative tissue growth. Using a genetic screen in Drosophila melanogaster, we identified the sterile 20-like kinase, Tao-1, as an SWH pathway member. Tao-1 controls various biological phenomena, including microtubule dynamics, animal behavior, and brain development. Here we describe a role for Tao-1 as a regulator of epithelial tissue growth that modulates activity of the core SWH pathway kinase cassette. Tao-1 functions together with Hippo to activate Warts-mediated repression of Yorkie. Tao-1's ability to control SWH pathway activity is evolutionarily conserved because human TAO1 can suppress activity of the Yorkie ortholog, YAP. Human TAO1 controls SWH pathway activity by phosphorylating, and activating, the Hippo ortholog, MST2. Given that SWH pathway activity is subverted in many human cancers, our findings identify human TAO kinases as potential tumor suppressor genes.
[Display omitted]
► Tao-1 kinase regulates the growth of developing epithelial tissues in Drosophila ► Tao-1 regulates SWH pathway activity in both Drosophila and human cultured cells ► Tao-1 functions together with Hippo to activate Warts and suppress Yorkie ► Human TAO1 can phosphorylate and activate human MST2</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>Cell differentiation, maturation, development, hematopoiesis</subject><subject>Cell Line</subject><subject>Cell physiology</subject><subject>Conserved Sequence</subject><subject>Drosophila melanogaster - enzymology</subject><subject>Drosophila melanogaster - growth & development</subject><subject>Drosophila melanogaster - metabolism</subject><subject>Drosophila Proteins - metabolism</subject><subject>Epithelium - growth & development</subject><subject>Epithelium - metabolism</subject><subject>Eye - growth & development</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Intracellular Signaling Peptides and Proteins - metabolism</subject><subject>MAP Kinase Kinase Kinases - metabolism</subject><subject>Medical sciences</subject><subject>Molecular and cellular biology</subject><subject>Nuclear Proteins - metabolism</subject><subject>Protein Kinases - metabolism</subject><subject>Protein-Serine-Threonine Kinases - metabolism</subject><subject>Signal Transduction</subject><subject>Trans-Activators - metabolism</subject><subject>Transcription Factors - metabolism</subject><subject>Viral diseases</subject><subject>Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</subject><subject>Wings, Animal - growth & development</subject><issn>1534-5807</issn><issn>1878-1551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1vEzEQhi0EoqXwDxDyBXHy4s_s-oKEImgRlUAQxNHy2rONw2ad2t5U-fc4SoAbp5nD874zehB6yWjDKFu83TQe9g7GhlPGGqobyvgjdMm6tiNMKfa47kpIojraXqBnOW9ojbGOPkUXnNNWMdldomG1Bvy9QAojYE7JGH4B_hwmmwGvbCQML-NUUhwzXoWcZ8DXKT6UNe4P-BvczaMtYbrD5dhix731MZGfNpVMbsJuF_FXW9YP9vAcPRnsmOHFeV6hHx8_rJY35PbL9afl-1vipGgL0T33ylNmh04Lr4YeeCeV9P1icLRlXnSd0qp3XmipnePaCa1Fv_BCDExQK67Qm1PvLsX7GXIx25CrpNFOEOdsNJWUCSFVJeWJdCnmnGAwuxS2Nh0Mo-Yo2GzMSbA5CjZUmyq4xl6dD8z9Fvzf0B-jFXh9Bmx2dhySnVzI_zjFuW6FrNy7EwdVxz5AMtkFmBz4kMAV42P4_ye_AUYImi4</recordid><startdate>20111115</startdate><enddate>20111115</enddate><creator>Poon, Carole L.C.</creator><creator>Lin, Jane I.</creator><creator>Zhang, Xiaomeng</creator><creator>Harvey, Kieran F.</creator><general>Elsevier Inc</general><general>Cell Press</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111115</creationdate><title>The Sterile 20-like Kinase Tao-1 Controls Tissue Growth by Regulating the Salvador-Warts-Hippo Pathway</title><author>Poon, Carole L.C. ; Lin, Jane I. ; Zhang, Xiaomeng ; Harvey, Kieran F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-9b2d5d01af893d5fbe28454db6fc071d388595bcd3949cc29c3993b6d33f130a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Cycle Proteins - metabolism</topic><topic>Cell differentiation, maturation, development, hematopoiesis</topic><topic>Cell Line</topic><topic>Cell physiology</topic><topic>Conserved Sequence</topic><topic>Drosophila melanogaster - enzymology</topic><topic>Drosophila melanogaster - growth & development</topic><topic>Drosophila melanogaster - metabolism</topic><topic>Drosophila Proteins - metabolism</topic><topic>Epithelium - growth & development</topic><topic>Epithelium - metabolism</topic><topic>Eye - growth & development</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Intracellular Signaling Peptides and Proteins - metabolism</topic><topic>MAP Kinase Kinase Kinases - metabolism</topic><topic>Medical sciences</topic><topic>Molecular and cellular biology</topic><topic>Nuclear Proteins - metabolism</topic><topic>Protein Kinases - metabolism</topic><topic>Protein-Serine-Threonine Kinases - metabolism</topic><topic>Signal Transduction</topic><topic>Trans-Activators - metabolism</topic><topic>Transcription Factors - metabolism</topic><topic>Viral diseases</topic><topic>Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</topic><topic>Wings, Animal - growth & development</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Poon, Carole L.C.</creatorcontrib><creatorcontrib>Lin, Jane I.</creatorcontrib><creatorcontrib>Zhang, Xiaomeng</creatorcontrib><creatorcontrib>Harvey, Kieran F.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Poon, Carole L.C.</au><au>Lin, Jane I.</au><au>Zhang, Xiaomeng</au><au>Harvey, Kieran F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Sterile 20-like Kinase Tao-1 Controls Tissue Growth by Regulating the Salvador-Warts-Hippo Pathway</atitle><jtitle>Developmental cell</jtitle><addtitle>Dev Cell</addtitle><date>2011-11-15</date><risdate>2011</risdate><volume>21</volume><issue>5</issue><spage>896</spage><epage>906</epage><pages>896-906</pages><issn>1534-5807</issn><eissn>1878-1551</eissn><abstract>The Salvador-Warts-Hippo (SWH) pathway is a complex signaling network that controls both developmental and regenerative tissue growth. Using a genetic screen in Drosophila melanogaster, we identified the sterile 20-like kinase, Tao-1, as an SWH pathway member. Tao-1 controls various biological phenomena, including microtubule dynamics, animal behavior, and brain development. Here we describe a role for Tao-1 as a regulator of epithelial tissue growth that modulates activity of the core SWH pathway kinase cassette. Tao-1 functions together with Hippo to activate Warts-mediated repression of Yorkie. Tao-1's ability to control SWH pathway activity is evolutionarily conserved because human TAO1 can suppress activity of the Yorkie ortholog, YAP. Human TAO1 controls SWH pathway activity by phosphorylating, and activating, the Hippo ortholog, MST2. Given that SWH pathway activity is subverted in many human cancers, our findings identify human TAO kinases as potential tumor suppressor genes.
[Display omitted]
► Tao-1 kinase regulates the growth of developing epithelial tissues in Drosophila ► Tao-1 regulates SWH pathway activity in both Drosophila and human cultured cells ► Tao-1 functions together with Hippo to activate Warts and suppress Yorkie ► Human TAO1 can phosphorylate and activate human MST2</abstract><cop>Cambridge, MA</cop><pub>Elsevier Inc</pub><pmid>22075148</pmid><doi>10.1016/j.devcel.2011.09.012</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biological and medical sciences Cell Cycle Proteins - metabolism Cell differentiation, maturation, development, hematopoiesis Cell Line Cell physiology Conserved Sequence Drosophila melanogaster - enzymology Drosophila melanogaster - growth & development Drosophila melanogaster - metabolism Drosophila Proteins - metabolism Epithelium - growth & development Epithelium - metabolism Eye - growth & development Female Fundamental and applied biological sciences. Psychology Human viral diseases Humans Infectious diseases Intracellular Signaling Peptides and Proteins - metabolism MAP Kinase Kinase Kinases - metabolism Medical sciences Molecular and cellular biology Nuclear Proteins - metabolism Protein Kinases - metabolism Protein-Serine-Threonine Kinases - metabolism Signal Transduction Trans-Activators - metabolism Transcription Factors - metabolism Viral diseases Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye Wings, Animal - growth & development |
| title | The Sterile 20-like Kinase Tao-1 Controls Tissue Growth by Regulating the Salvador-Warts-Hippo Pathway |
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