Immunostimulatory activity of ConBr: a focus on splenocyte proliferation and proliferative cytokine secretion
Lectins constitute a class of glycoproteins, which are capable of selectively and reversibly binding to carbohydrates, distinguishing small structural differences in complex oligosaccharides. Studies have shown that the binding of lectins to cell-surface carbohydrates can lead to various effects suc...
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| Veröffentlicht in: | Cell and tissue research 2011-11, Vol.346 (2), p.237-244 |
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| creator | de Oliveira Silva, Flávio das Neves Santos, Priscila de Melo, Cristiane Moutinho Lagos Teixeira, Edson Holanda de Sousa Cavada, Benildo Pereira, Valéria Alves Rêgo Porto, Ana Lúcia Figueiredo Cajazeiras, João Batista Arruda, Francisco Vassiliepe Sousa Almeida, Alysson Chaves |
| description | Lectins constitute a class of glycoproteins, which are capable of selectively and reversibly binding to carbohydrates, distinguishing small structural differences in complex oligosaccharides. Studies have shown that the binding of lectins to cell-surface carbohydrates can lead to various effects such as cellular proliferation, histamine release and cytokine production.
Canavalia brasiliensis
lectin (ConBr) is a (D-mannose) D-glucose lectin. In this study, murine splenocytes were cultured to determine the effect of ConBr on cell proliferation, nitric oxide (NO) release and cytokine secretion. In addition, cellular viability assays were performed to evaluate any mitogenic activity induced by this lectin. ConBr significantly increased cell proliferation with minimal cell damage. This lectin was able to induce an increased production of cytokines such as IL-2, IL-6 and IFN-γ and a decreased production of IL- 10. The release of NO was also observed. The results of this study indicate that ConBr could potentially be used as an immunomodulator. |
| doi_str_mv | 10.1007/s00441-011-1239-x |
| format | Article |
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Canavalia brasiliensis
lectin (ConBr) is a (D-mannose) D-glucose lectin. In this study, murine splenocytes were cultured to determine the effect of ConBr on cell proliferation, nitric oxide (NO) release and cytokine secretion. In addition, cellular viability assays were performed to evaluate any mitogenic activity induced by this lectin. ConBr significantly increased cell proliferation with minimal cell damage. This lectin was able to induce an increased production of cytokines such as IL-2, IL-6 and IFN-γ and a decreased production of IL- 10. The release of NO was also observed. The results of this study indicate that ConBr could potentially be used as an immunomodulator.</description><identifier>ISSN: 0302-766X</identifier><identifier>EISSN: 1432-0878</identifier><identifier>DOI: 10.1007/s00441-011-1239-x</identifier><identifier>PMID: 22009293</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adjuvants, Immunologic - pharmacology ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Carbohydrates ; Cell growth ; Cell proliferation ; Cell Proliferation - drug effects ; Cell Survival - drug effects ; Cells, Cultured ; Concanavalin A - pharmacology ; Cytokines ; Cytokines - secretion ; Dextrose ; gamma -Interferon ; Glucose ; Glucose metabolism ; Glycoproteins ; Histamine ; Human Genetics ; Immune system ; Immunization ; Immunomodulation ; Immunostimulation ; Interferon-gamma - biosynthesis ; Interleukin 2 ; Interleukin 6 ; Interleukin-10 - biosynthesis ; Interleukin-2 - biosynthesis ; Interleukin-6 - biosynthesis ; Lectins ; Male ; Mannose ; Mice ; Mice, Inbred BALB C ; Molecular Medicine ; Nitric oxide ; Nitric Oxide - secretion ; oligosaccharides ; Plant Lectins - pharmacology ; Proteomics ; Regular Article ; Rodents ; Spleen ; Spleen - cytology ; Spleen - drug effects ; Spleen - secretion ; Splenocytes</subject><ispartof>Cell and tissue research, 2011-11, Vol.346 (2), p.237-244</ispartof><rights>Springer-Verlag 2011</rights><rights>COPYRIGHT 2011 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c501t-b932f14e9b1a26dab23bfd5854c7cfe259599079dd6c97149b44260de94a8163</citedby><cites>FETCH-LOGICAL-c501t-b932f14e9b1a26dab23bfd5854c7cfe259599079dd6c97149b44260de94a8163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00441-011-1239-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00441-011-1239-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22009293$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Oliveira Silva, Flávio</creatorcontrib><creatorcontrib>das Neves Santos, Priscila</creatorcontrib><creatorcontrib>de Melo, Cristiane Moutinho Lagos</creatorcontrib><creatorcontrib>Teixeira, Edson Holanda</creatorcontrib><creatorcontrib>de Sousa Cavada, Benildo</creatorcontrib><creatorcontrib>Pereira, Valéria Alves Rêgo</creatorcontrib><creatorcontrib>Porto, Ana Lúcia Figueiredo</creatorcontrib><creatorcontrib>Cajazeiras, João Batista</creatorcontrib><creatorcontrib>Arruda, Francisco Vassiliepe Sousa</creatorcontrib><creatorcontrib>Almeida, Alysson Chaves</creatorcontrib><title>Immunostimulatory activity of ConBr: a focus on splenocyte proliferation and proliferative cytokine secretion</title><title>Cell and tissue research</title><addtitle>Cell Tissue Res</addtitle><addtitle>Cell Tissue Res</addtitle><description>Lectins constitute a class of glycoproteins, which are capable of selectively and reversibly binding to carbohydrates, distinguishing small structural differences in complex oligosaccharides. Studies have shown that the binding of lectins to cell-surface carbohydrates can lead to various effects such as cellular proliferation, histamine release and cytokine production.
Canavalia brasiliensis
lectin (ConBr) is a (D-mannose) D-glucose lectin. In this study, murine splenocytes were cultured to determine the effect of ConBr on cell proliferation, nitric oxide (NO) release and cytokine secretion. In addition, cellular viability assays were performed to evaluate any mitogenic activity induced by this lectin. ConBr significantly increased cell proliferation with minimal cell damage. This lectin was able to induce an increased production of cytokines such as IL-2, IL-6 and IFN-γ and a decreased production of IL- 10. The release of NO was also observed. The results of this study indicate that ConBr could potentially be used as an immunomodulator.</description><subject>Adjuvants, Immunologic - pharmacology</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Carbohydrates</subject><subject>Cell growth</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Cells, Cultured</subject><subject>Concanavalin A - pharmacology</subject><subject>Cytokines</subject><subject>Cytokines - secretion</subject><subject>Dextrose</subject><subject>gamma -Interferon</subject><subject>Glucose</subject><subject>Glucose metabolism</subject><subject>Glycoproteins</subject><subject>Histamine</subject><subject>Human Genetics</subject><subject>Immune system</subject><subject>Immunization</subject><subject>Immunomodulation</subject><subject>Immunostimulation</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Interleukin 2</subject><subject>Interleukin 6</subject><subject>Interleukin-10 - biosynthesis</subject><subject>Interleukin-2 - biosynthesis</subject><subject>Interleukin-6 - biosynthesis</subject><subject>Lectins</subject><subject>Male</subject><subject>Mannose</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Molecular Medicine</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - secretion</subject><subject>oligosaccharides</subject><subject>Plant Lectins - pharmacology</subject><subject>Proteomics</subject><subject>Regular Article</subject><subject>Rodents</subject><subject>Spleen</subject><subject>Spleen - cytology</subject><subject>Spleen - drug effects</subject><subject>Spleen - secretion</subject><subject>Splenocytes</subject><issn>0302-766X</issn><issn>1432-0878</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kktv1TAQhS0EopfCD2CDIpCATcr4kYe7K1c8KlVi0wU7y3HGrUtiX-yk6v33OEqBFgHywtLMd8Y-o0PIcwpHFKB5lwCEoCVQWlLGZXnzgGyo4KyEtmkfkg1wYGVT118PyJOUrgCoqGv5mBwwBiCZ5Bsyno7j7EOa3DgPegpxX2gzuWs37Ytgi23w7-NxoQsbzJyK4Iu0G9AHs5-w2MUwOItRTy43tO_vVq6xyFD45jwWCU3EBXpKHlk9JHx2ex-S848fzrefy7Mvn063J2elqYBOZSc5s1Sg7Khmda87xjvbV20lTGMsskpWUkIj-742sqFCdkKwGnqUQre05ofkzTo2_-f7jGlSo0sGh0F7DHNSEgTkBUKbybf_JSlILgQXjGX05R_oVZijzzbyPC5aISTN0KsVutADKudtmKI2y0x1wqsKqqoWy6tHf6Hy6XF0Jni0LtfvCV7fEVyiHqbLFIZ52Wm6D9IVNDGkFNGqXXSjjvvsRC2ZUWtmVM6MWjKjbrLmxa2xuRux_6X4GZIMsBVIueUvMP52_u-pPwBCL8tR</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>de Oliveira Silva, Flávio</creator><creator>das Neves Santos, Priscila</creator><creator>de Melo, Cristiane Moutinho Lagos</creator><creator>Teixeira, Edson Holanda</creator><creator>de Sousa Cavada, Benildo</creator><creator>Pereira, Valéria Alves Rêgo</creator><creator>Porto, Ana Lúcia Figueiredo</creator><creator>Cajazeiras, João Batista</creator><creator>Arruda, Francisco Vassiliepe Sousa</creator><creator>Almeida, Alysson Chaves</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SS</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20111101</creationdate><title>Immunostimulatory activity of ConBr: a focus on splenocyte proliferation and proliferative cytokine secretion</title><author>de Oliveira Silva, Flávio ; das Neves Santos, Priscila ; de Melo, Cristiane Moutinho Lagos ; Teixeira, Edson Holanda ; de Sousa Cavada, Benildo ; Pereira, Valéria Alves Rêgo ; Porto, Ana Lúcia Figueiredo ; Cajazeiras, João Batista ; Arruda, Francisco Vassiliepe Sousa ; Almeida, Alysson Chaves</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c501t-b932f14e9b1a26dab23bfd5854c7cfe259599079dd6c97149b44260de94a8163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adjuvants, Immunologic - pharmacology</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Carbohydrates</topic><topic>Cell growth</topic><topic>Cell proliferation</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Cells, Cultured</topic><topic>Concanavalin A - pharmacology</topic><topic>Cytokines</topic><topic>Cytokines - secretion</topic><topic>Dextrose</topic><topic>gamma -Interferon</topic><topic>Glucose</topic><topic>Glucose metabolism</topic><topic>Glycoproteins</topic><topic>Histamine</topic><topic>Human Genetics</topic><topic>Immune system</topic><topic>Immunization</topic><topic>Immunomodulation</topic><topic>Immunostimulation</topic><topic>Interferon-gamma - biosynthesis</topic><topic>Interleukin 2</topic><topic>Interleukin 6</topic><topic>Interleukin-10 - biosynthesis</topic><topic>Interleukin-2 - biosynthesis</topic><topic>Interleukin-6 - biosynthesis</topic><topic>Lectins</topic><topic>Male</topic><topic>Mannose</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Molecular Medicine</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - secretion</topic><topic>oligosaccharides</topic><topic>Plant Lectins - pharmacology</topic><topic>Proteomics</topic><topic>Regular Article</topic><topic>Rodents</topic><topic>Spleen</topic><topic>Spleen - cytology</topic><topic>Spleen - drug effects</topic><topic>Spleen - secretion</topic><topic>Splenocytes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Oliveira Silva, Flávio</creatorcontrib><creatorcontrib>das Neves Santos, Priscila</creatorcontrib><creatorcontrib>de Melo, Cristiane Moutinho Lagos</creatorcontrib><creatorcontrib>Teixeira, Edson Holanda</creatorcontrib><creatorcontrib>de Sousa Cavada, Benildo</creatorcontrib><creatorcontrib>Pereira, Valéria Alves Rêgo</creatorcontrib><creatorcontrib>Porto, Ana Lúcia Figueiredo</creatorcontrib><creatorcontrib>Cajazeiras, João Batista</creatorcontrib><creatorcontrib>Arruda, Francisco Vassiliepe Sousa</creatorcontrib><creatorcontrib>Almeida, Alysson Chaves</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell and tissue research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Oliveira Silva, Flávio</au><au>das Neves Santos, Priscila</au><au>de Melo, Cristiane Moutinho Lagos</au><au>Teixeira, Edson Holanda</au><au>de Sousa Cavada, Benildo</au><au>Pereira, Valéria Alves Rêgo</au><au>Porto, Ana Lúcia Figueiredo</au><au>Cajazeiras, João Batista</au><au>Arruda, Francisco Vassiliepe Sousa</au><au>Almeida, Alysson Chaves</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunostimulatory activity of ConBr: a focus on splenocyte proliferation and proliferative cytokine secretion</atitle><jtitle>Cell and tissue research</jtitle><stitle>Cell Tissue Res</stitle><addtitle>Cell Tissue Res</addtitle><date>2011-11-01</date><risdate>2011</risdate><volume>346</volume><issue>2</issue><spage>237</spage><epage>244</epage><pages>237-244</pages><issn>0302-766X</issn><eissn>1432-0878</eissn><abstract>Lectins constitute a class of glycoproteins, which are capable of selectively and reversibly binding to carbohydrates, distinguishing small structural differences in complex oligosaccharides. Studies have shown that the binding of lectins to cell-surface carbohydrates can lead to various effects such as cellular proliferation, histamine release and cytokine production.
Canavalia brasiliensis
lectin (ConBr) is a (D-mannose) D-glucose lectin. In this study, murine splenocytes were cultured to determine the effect of ConBr on cell proliferation, nitric oxide (NO) release and cytokine secretion. In addition, cellular viability assays were performed to evaluate any mitogenic activity induced by this lectin. ConBr significantly increased cell proliferation with minimal cell damage. This lectin was able to induce an increased production of cytokines such as IL-2, IL-6 and IFN-γ and a decreased production of IL- 10. The release of NO was also observed. The results of this study indicate that ConBr could potentially be used as an immunomodulator.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22009293</pmid><doi>10.1007/s00441-011-1239-x</doi><tpages>8</tpages></addata></record> |
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| ispartof | Cell and tissue research, 2011-11, Vol.346 (2), p.237-244 |
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| subjects | Adjuvants, Immunologic - pharmacology Animals Biomedical and Life Sciences Biomedicine Carbohydrates Cell growth Cell proliferation Cell Proliferation - drug effects Cell Survival - drug effects Cells, Cultured Concanavalin A - pharmacology Cytokines Cytokines - secretion Dextrose gamma -Interferon Glucose Glucose metabolism Glycoproteins Histamine Human Genetics Immune system Immunization Immunomodulation Immunostimulation Interferon-gamma - biosynthesis Interleukin 2 Interleukin 6 Interleukin-10 - biosynthesis Interleukin-2 - biosynthesis Interleukin-6 - biosynthesis Lectins Male Mannose Mice Mice, Inbred BALB C Molecular Medicine Nitric oxide Nitric Oxide - secretion oligosaccharides Plant Lectins - pharmacology Proteomics Regular Article Rodents Spleen Spleen - cytology Spleen - drug effects Spleen - secretion Splenocytes |
| title | Immunostimulatory activity of ConBr: a focus on splenocyte proliferation and proliferative cytokine secretion |
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