Hypoxia and nitric oxide exposure promote apoptotic signaling in contractile pulmonary arterial smooth muscle but not in pulmonary epithelium

Rationale Neonatal pulmonary hypertension is characterized by hypoxia, abnormal vascular remodeling, and impaired alveolarization. Nitric oxide (NO) regulates cell replication and activation of apoptosis. Our objective was to examine cell phenotype‐specific effects of hypoxia and NO exposure on cumu...

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Veröffentlicht in:	Pediatric pulmonology 2011-12, Vol.46 (12), p.1194-1208
Hauptverfasser:	Postolow, F., Fediuk, J., Nolette, N., Hinton, M., Dakshinamurti, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Apoptosis BAX/BCl2 bcl-2-Associated X Protein - analysis Biological and medical sciences caspase 3 Caspase 3 - analysis Cell Survival Cells, Cultured General aspects Hypertension, Pulmonary - metabolism hypoxia Hypoxia - metabolism Medical sciences Muscle Cells - metabolism Muscle, Smooth, Vascular - metabolism nitric oxide Nitric Oxide - metabolism Pneumology Proto-Oncogene Proteins c-bcl-2 - analysis Pulmonary Artery - metabolism pulmonary epithelium pulmonary hypertension of the newborn Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Respiratory Mucosa - metabolism Swine
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