Proteasome inhibitor lactacystin augments natural killer cell cytotoxicity of myeloma via downregulation of HLA class I

► Proteasome inhibitors decreased HLA class I surface expression on human MM cells. ► LAC blocks surface re-expression of newly synthesized class I in OPM2 after acid treatment. ► Proteasome inhibition by LAC augmented NK cell-mediated lysis of MM cells. ► The degree of downregulation of class I was...

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Veröffentlicht in:	Biochemical and biophysical research communications 2011-11, Vol.415 (1), p.187-192
Hauptverfasser:	Wu, Xiaosong, Shao, Yang, Tao, Yi, Ai, Gongwen, Wei, Rong, Meng, Xiuqin, Hou, Jun, Han, Ying, Zhan, Fenghuang, Zheng, Junhua, Shi, Jumei
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - analogs & derivatives Acetylcysteine - pharmacology Cell Line, Tumor Cysteine Proteinase Inhibitors - pharmacology Cytotoxicity, Immunologic - drug effects Down-Regulation Histocompatibility Antigens Class I - immunology Humans Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Lactacystin Multiple Myeloma - immunology Myeloma Natural killer cell Proteasome inhibitor Proteasome Inhibitors
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