The serine/threonine kinase ULK1 is a target of multiple phosphorylation events

Autophagy is a cellular degradation process that is up-regulated upon starvation. Nutrition-dependent regulation of mTOR (mammalian target of rapamycin) is a major determinant of autophagy. RTK (receptor tyrosine kinase) signalling and AMPK (AMP-activated protein kinase) converge upon mTOR to suppre...

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Veröffentlicht in:	Biochemical journal 2011-12, Vol.440 (2), p.283-291
Hauptverfasser:	Bach, Markus, Larance, Mark, James, David E, Ramm, Georg
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 Proteins - metabolism Amino Acid Sequence AMP-Activated Protein Kinases - metabolism Autophagy - physiology Autophagy-Related Protein-1 Homolog HEK293 Cells Humans Intracellular Signaling Peptides and Proteins - metabolism Phosphorylation Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism TOR Serine-Threonine Kinases - metabolism
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