Cross-talk between chronic lymphocytic leukemia cells and bone marrow endothelial cells: role of signal transducer and activator of transcription 3

Summary Chronic lymphocytic leukemia bone marrow is characterized by increased angiogenesis. However, the molecular mediators of neovascularization and the biologic significance of increased endothelial cell proliferation in chronic lymphocytic leukemia require further investigation. Because signal...

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Veröffentlicht in:	Human pathology 2011-12, Vol.42 (12), p.1989-2000
Hauptverfasser:	Badoux, Xavier, MD, Bueso-Ramos, Carlos, MD, PhD, Harris, David, BS, Li, Ping, PhD, Liu, Zhiming, BS, Burger, Jan, MD, O'Brien, Susan, MD, Ferrajoli, Alessandra, MD, Keating, Michael J., MD, Estrov, Zeev, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Apoptosis Biological and medical sciences Bone marrow Bone Marrow - blood supply Bone Marrow - physiology Bone Marrow Cells - physiology Cell Communication - physiology Cell culture Cell Line Cell Proliferation Chromatin Immunoprecipitation CLL Deoxyribonucleic acid DNA Down-Regulation - genetics Endothelial cells Endothelial Cells - physiology Hematologic and hematopoietic diseases Human Umbilical Vein Endothelial Cells Humans Investigative techniques, diagnostic techniques (general aspects) Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Leukemia, Lymphocytic, Chronic, B-Cell - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Neovascularization, Pathologic - metabolism Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Promoter Regions, Genetic - genetics Proteins RNA, Messenger - genetics RNA, Small Interfering Signal transduction STAT3 STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Stroma Up-Regulation - genetics Vascular endothelial growth factor Vascular Endothelial Growth Factor A - blood Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-2 - metabolism VEGF
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