EW-7195, a novel inhibitor of ALK5 kinase inhibits EMT and breast cancer metastasis to lung

Abstract Recently, researchers are actively pursuing efforts to develop potent and selective ALK5 (TβRI) kinase inhibitors for clinical development. In this study, the authors examined a novel small molecule inhibitor of ALK5, 3-((4-([1,2,4]triazolo[1,5- a ]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1 H...

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Veröffentlicht in:	European journal of cancer (1990) 2011-11, Vol.47 (17), p.2642-2653
Hauptverfasser:	Park, Chul-Yong, Son, Jee-Yeon, Jin, Cheng Hua, Nam, Jeong-Suk, Kim, Dae-Kee, Sheen, Yhun Yhong
Format:	Artikel
Sprache:	eng
Schlagworte:	ALK5 inhibitor Animals Antineoplastic Agents - therapeutic use Biological and medical sciences Breast cancer Breast Neoplasms - drug therapy Cell Line, Tumor Cell Movement - drug effects Cell Transformation, Neoplastic - drug effects Epithelial-Mesenchymal Transition - drug effects Epithelial-to-mesenchymal transition Female Hematology, Oncology and Palliative Medicine Hep G2 Cells - enzymology Humans Luciferases - metabolism Lung Neoplasms - prevention & control Lung Neoplasms - secondary Medical sciences Metastasis Mice Mice, Transgenic Neoplasm Invasiveness Pharmacology. Drug treatments Phosphorylation - drug effects Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Protein-Serine-Threonine Kinases - antagonists & inhibitors Pyridines - therapeutic use Receptors, Transforming Growth Factor beta - antagonists & inhibitors Smad2 Protein - metabolism TGF-β Triazoles - therapeutic use Tumors
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