Regeneration of cervix after excisional treatment for cervical intraepithelial neoplasia: a study of collagen distribution
Please cite this paper as: Phadnis S, Atilade A, Bowring J, Kyrgiou M, Young M, Evans H, Paraskevaidis E, Walker P. Regeneration of cervix after excisional treatment for cervical intraepithelial neoplasia: a study of collagen distribution. BJOG 2011;118:1585–1591. Objective To study the distributio...
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| Veröffentlicht in: | BJOG : an international journal of obstetrics and gynaecology 2011-12, Vol.118 (13), p.1585-1591 |
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| container_title | BJOG : an international journal of obstetrics and gynaecology |
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| creator | Phadnis, SV Atilade, A Bowring, J Kyrgiou, M Young, MPA Evans, H Paraskevaidis, E Walker, P |
| description | Please cite this paper as: Phadnis S, Atilade A, Bowring J, Kyrgiou M, Young M, Evans H, Paraskevaidis E, Walker P. Regeneration of cervix after excisional treatment for cervical intraepithelial neoplasia: a study of collagen distribution. BJOG 2011;118:1585–1591.
Objective To study the distribution of collagen in the regenerated cervical tissue after excisional treatment for cervical intraepithelial neoplasia (CIN).
Design Cohort study.
Setting A large tertiary teaching hospital in London.
Population Women who underwent repeat excisional treatment for treatment failure or persistent CIN.
Methods Eligible women who underwent a repeat excisional treatment for treatment failure, including hysterectomy, between January 2002 and December 2007 in our colposcopy unit were identified by the Infoflex® database and SNOMED encoded histopathology database. Collagen expression was assessed using picro‐Sirius red stain and the intensity of staining was compared in paired specimens from the first and second treatments.
Main outcome measure Differences in collagen expression were examined in the paired excisional treatment specimens.
Results A total of 17 women were included. Increased collagen expression in the regenerated cervical tissue of the second cone compared with the first cone was noted in six women, decreased expression was noted in five women, and the pattern of collagen distribution was equivocal in six women.
Conclusion There is no overall change in collagen distribution during regeneration following excisional treatment for CIN. |
| doi_str_mv | 10.1111/j.1471-0528.2011.03085.x |
| format | Article |
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Objective To study the distribution of collagen in the regenerated cervical tissue after excisional treatment for cervical intraepithelial neoplasia (CIN).
Design Cohort study.
Setting A large tertiary teaching hospital in London.
Population Women who underwent repeat excisional treatment for treatment failure or persistent CIN.
Methods Eligible women who underwent a repeat excisional treatment for treatment failure, including hysterectomy, between January 2002 and December 2007 in our colposcopy unit were identified by the Infoflex® database and SNOMED encoded histopathology database. Collagen expression was assessed using picro‐Sirius red stain and the intensity of staining was compared in paired specimens from the first and second treatments.
Main outcome measure Differences in collagen expression were examined in the paired excisional treatment specimens.
Results A total of 17 women were included. Increased collagen expression in the regenerated cervical tissue of the second cone compared with the first cone was noted in six women, decreased expression was noted in five women, and the pattern of collagen distribution was equivocal in six women.
Conclusion There is no overall change in collagen distribution during regeneration following excisional treatment for CIN.</description><identifier>ISSN: 1470-0328</identifier><identifier>EISSN: 1471-0528</identifier><identifier>DOI: 10.1111/j.1471-0528.2011.03085.x</identifier><identifier>PMID: 21895948</identifier><identifier>CODEN: BIOGFQ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Cervical Intraepithelial Neoplasia - metabolism ; Cervical Intraepithelial Neoplasia - surgery ; Cervix biopsy ; cervix cone ; Cervix Uteri - metabolism ; Cervix Uteri - physiology ; Cohort Studies ; Collagen ; Collagen - metabolism ; Electrosurgery - methods ; Female ; Female genital diseases ; Gynecology ; Gynecology. Andrology. Obstetrics ; Humans ; large loop excision of transformation zone ; Medical sciences ; Medical treatment ; Middle Aged ; Neoplasm Recurrence, Local - metabolism ; Neoplasm Recurrence, Local - surgery ; Regeneration - physiology ; Reoperation ; Tumors ; Uterine Cervical Neoplasms - metabolism ; Uterine Cervical Neoplasms - surgery ; Womens health</subject><ispartof>BJOG : an international journal of obstetrics and gynaecology, 2011-12, Vol.118 (13), p.1585-1591</ispartof><rights>2011 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2011 RCOG</rights><rights>2015 INIST-CNRS</rights><rights>2011 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2011 RCOG.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3765-365d220dcabf987d6b961a4d2334454fadd682ba0d34d39b5f3f61b011acb1373</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-0528.2011.03085.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-0528.2011.03085.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24757148$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21895948$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Phadnis, SV</creatorcontrib><creatorcontrib>Atilade, A</creatorcontrib><creatorcontrib>Bowring, J</creatorcontrib><creatorcontrib>Kyrgiou, M</creatorcontrib><creatorcontrib>Young, MPA</creatorcontrib><creatorcontrib>Evans, H</creatorcontrib><creatorcontrib>Paraskevaidis, E</creatorcontrib><creatorcontrib>Walker, P</creatorcontrib><title>Regeneration of cervix after excisional treatment for cervical intraepithelial neoplasia: a study of collagen distribution</title><title>BJOG : an international journal of obstetrics and gynaecology</title><addtitle>BJOG</addtitle><description>Please cite this paper as: Phadnis S, Atilade A, Bowring J, Kyrgiou M, Young M, Evans H, Paraskevaidis E, Walker P. Regeneration of cervix after excisional treatment for cervical intraepithelial neoplasia: a study of collagen distribution. BJOG 2011;118:1585–1591.
Objective To study the distribution of collagen in the regenerated cervical tissue after excisional treatment for cervical intraepithelial neoplasia (CIN).
Design Cohort study.
Setting A large tertiary teaching hospital in London.
Population Women who underwent repeat excisional treatment for treatment failure or persistent CIN.
Methods Eligible women who underwent a repeat excisional treatment for treatment failure, including hysterectomy, between January 2002 and December 2007 in our colposcopy unit were identified by the Infoflex® database and SNOMED encoded histopathology database. Collagen expression was assessed using picro‐Sirius red stain and the intensity of staining was compared in paired specimens from the first and second treatments.
Main outcome measure Differences in collagen expression were examined in the paired excisional treatment specimens.
Results A total of 17 women were included. Increased collagen expression in the regenerated cervical tissue of the second cone compared with the first cone was noted in six women, decreased expression was noted in five women, and the pattern of collagen distribution was equivocal in six women.
Conclusion There is no overall change in collagen distribution during regeneration following excisional treatment for CIN.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cervical Intraepithelial Neoplasia - metabolism</subject><subject>Cervical Intraepithelial Neoplasia - surgery</subject><subject>Cervix biopsy</subject><subject>cervix cone</subject><subject>Cervix Uteri - metabolism</subject><subject>Cervix Uteri - physiology</subject><subject>Cohort Studies</subject><subject>Collagen</subject><subject>Collagen - metabolism</subject><subject>Electrosurgery - methods</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>large loop excision of transformation zone</subject><subject>Medical sciences</subject><subject>Medical treatment</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - metabolism</subject><subject>Neoplasm Recurrence, Local - surgery</subject><subject>Regeneration - physiology</subject><subject>Reoperation</subject><subject>Tumors</subject><subject>Uterine Cervical Neoplasms - metabolism</subject><subject>Uterine Cervical Neoplasms - surgery</subject><subject>Womens health</subject><issn>1470-0328</issn><issn>1471-0528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkdtOGzEQhq2qqEmBV6gspIqrXXzaE1IvIKItKBISgmtrdm0XR5vdYHsh4enxJoFK-MYznk8z4_9HCFOS0njOFikVBU1IxsqUEUpTwkmZpesvaPpR-LqNSUI4Kyfou_cLQmjOCP-GJoyWVVaJcope7_Q_3WkHwfYd7g1utHu2awwmaIf1urE-FqDFwWkIS90FbHq3o5r4bLvgQK9seNStjXmn-1UL3sI5BuzDoDbbpn3bQpyDlfXB2XoYpx2hAwOt18f7-xA9_L66n_1N5rd_rmcX86ThRZ4lPM8UY0Q1UJuqLFReVzkFoRjnQmTCgFJ5yWogigvFqzoz3OS0jqpAU1Ne8EN0uuu7cv3ToH2QS-sbHTeKyw5eVkQQUghKI3nyiVz0g4u_HyEepWPF2O7HHhrqpVZy5ewS3Ea-axqBn3sAfJTIOOiiiv85UWQF3XK_dtyLbfXmo06JHD2WCzlaKUcr5eix3Hos1_Ly5naM-Bss-ptH</recordid><startdate>201112</startdate><enddate>201112</enddate><creator>Phadnis, SV</creator><creator>Atilade, A</creator><creator>Bowring, J</creator><creator>Kyrgiou, M</creator><creator>Young, MPA</creator><creator>Evans, H</creator><creator>Paraskevaidis, E</creator><creator>Walker, P</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QP</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201112</creationdate><title>Regeneration of cervix after excisional treatment for cervical intraepithelial neoplasia: a study of collagen distribution</title><author>Phadnis, SV ; Atilade, A ; Bowring, J ; Kyrgiou, M ; Young, MPA ; Evans, H ; Paraskevaidis, E ; Walker, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3765-365d220dcabf987d6b961a4d2334454fadd682ba0d34d39b5f3f61b011acb1373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cervical Intraepithelial Neoplasia - metabolism</topic><topic>Cervical Intraepithelial Neoplasia - surgery</topic><topic>Cervix biopsy</topic><topic>cervix cone</topic><topic>Cervix Uteri - metabolism</topic><topic>Cervix Uteri - physiology</topic><topic>Cohort Studies</topic><topic>Collagen</topic><topic>Collagen - metabolism</topic><topic>Electrosurgery - methods</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>large loop excision of transformation zone</topic><topic>Medical sciences</topic><topic>Medical treatment</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - metabolism</topic><topic>Neoplasm Recurrence, Local - surgery</topic><topic>Regeneration - physiology</topic><topic>Reoperation</topic><topic>Tumors</topic><topic>Uterine Cervical Neoplasms - metabolism</topic><topic>Uterine Cervical Neoplasms - surgery</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Phadnis, SV</creatorcontrib><creatorcontrib>Atilade, A</creatorcontrib><creatorcontrib>Bowring, J</creatorcontrib><creatorcontrib>Kyrgiou, M</creatorcontrib><creatorcontrib>Young, MPA</creatorcontrib><creatorcontrib>Evans, H</creatorcontrib><creatorcontrib>Paraskevaidis, E</creatorcontrib><creatorcontrib>Walker, P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Phadnis, SV</au><au>Atilade, A</au><au>Bowring, J</au><au>Kyrgiou, M</au><au>Young, MPA</au><au>Evans, H</au><au>Paraskevaidis, E</au><au>Walker, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regeneration of cervix after excisional treatment for cervical intraepithelial neoplasia: a study of collagen distribution</atitle><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle><addtitle>BJOG</addtitle><date>2011-12</date><risdate>2011</risdate><volume>118</volume><issue>13</issue><spage>1585</spage><epage>1591</epage><pages>1585-1591</pages><issn>1470-0328</issn><eissn>1471-0528</eissn><coden>BIOGFQ</coden><abstract>Please cite this paper as: Phadnis S, Atilade A, Bowring J, Kyrgiou M, Young M, Evans H, Paraskevaidis E, Walker P. Regeneration of cervix after excisional treatment for cervical intraepithelial neoplasia: a study of collagen distribution. BJOG 2011;118:1585–1591.
Objective To study the distribution of collagen in the regenerated cervical tissue after excisional treatment for cervical intraepithelial neoplasia (CIN).
Design Cohort study.
Setting A large tertiary teaching hospital in London.
Population Women who underwent repeat excisional treatment for treatment failure or persistent CIN.
Methods Eligible women who underwent a repeat excisional treatment for treatment failure, including hysterectomy, between January 2002 and December 2007 in our colposcopy unit were identified by the Infoflex® database and SNOMED encoded histopathology database. Collagen expression was assessed using picro‐Sirius red stain and the intensity of staining was compared in paired specimens from the first and second treatments.
Main outcome measure Differences in collagen expression were examined in the paired excisional treatment specimens.
Results A total of 17 women were included. Increased collagen expression in the regenerated cervical tissue of the second cone compared with the first cone was noted in six women, decreased expression was noted in five women, and the pattern of collagen distribution was equivocal in six women.
Conclusion There is no overall change in collagen distribution during regeneration following excisional treatment for CIN.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21895948</pmid><doi>10.1111/j.1471-0528.2011.03085.x</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged Biological and medical sciences Cervical Intraepithelial Neoplasia - metabolism Cervical Intraepithelial Neoplasia - surgery Cervix biopsy cervix cone Cervix Uteri - metabolism Cervix Uteri - physiology Cohort Studies Collagen Collagen - metabolism Electrosurgery - methods Female Female genital diseases Gynecology Gynecology. Andrology. Obstetrics Humans large loop excision of transformation zone Medical sciences Medical treatment Middle Aged Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - surgery Regeneration - physiology Reoperation Tumors Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - surgery Womens health |
| title | Regeneration of cervix after excisional treatment for cervical intraepithelial neoplasia: a study of collagen distribution |
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