High fat diet induced diabetic cardiomyopathy

Abstract In response to a chronic high plasma concentration of long-chain fatty acids (FAs), the heart is forced to increase the uptake of FA at the cost of glucose. This switch in metabolic substrate uptake is accompanied by an increased presence of the FA transporter CD36 at the cardiac plasma mem...

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Veröffentlicht in:	Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2011-11, Vol.85 (5), p.219-225
Hauptverfasser:	Dirkx, Ellen, Schwenk, Robert W, Glatz, Jan F.C, Luiken, Joost J.F.P, van Eys, Guillaume J.J.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Biological and medical sciences Cardiology. Vascular system CD36 Antigens - metabolism Cell Membrane - metabolism Cell Membrane - pathology Ceramides - metabolism Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Diabetes. Impaired glucose tolerance Diabetic Cardiomyopathies - etiology Diabetic Cardiomyopathies - metabolism Diabetic Cardiomyopathies - pathology Dietary Fats - adverse effects Diglycerides - metabolism Endocrine pancreas. Apud cells (diseases) Endocrinology & Metabolism Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fatty Acids - metabolism Fundamental and applied biological sciences. Psychology Heart Humans Medical sciences Mitochondria, Heart - metabolism Mitochondria, Heart - pathology Myocarditis. Cardiomyopathies Myocardium - metabolism Myocardium - pathology Oxidation-Reduction Peroxisome Proliferator-Activated Receptors - metabolism Reactive Oxygen Species - metabolism Vertebrates: endocrinology
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