Lipid body function in eicosanoid synthesis: An update
Abstract Eicosanoids (prostaglandins, leukotrienes and lipoxins) are signaling lipids derived from arachidonic acid metabolism that have important roles in physiological and pathological processes. Lately, intracellular compartmentalization of eicosanoid–synthetic machinery has emerged as a key comp...
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| Veröffentlicht in: | Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2011-11, Vol.85 (5), p.205-213 |
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| container_title | Prostaglandins, leukotrienes and essential fatty acids |
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| creator | Bozza, Patricia T Bakker-Abreu, Ilka Navarro-Xavier, Roberta A Bandeira-Melo, Christianne |
| description | Abstract Eicosanoids (prostaglandins, leukotrienes and lipoxins) are signaling lipids derived from arachidonic acid metabolism that have important roles in physiological and pathological processes. Lately, intracellular compartmentalization of eicosanoid–synthetic machinery has emerged as a key component in the regulation of eicosanoid synthesis and functions. Over the past years substantial progresses have been made demonstrating that precursors and enzymes involved in eicosanoid synthesis localize at lipid bodies (also known as lipid droplets) and lipid bodies are distinct sites for eicosanoid generation. Here we will review the current knowledge on the functions of lipid bodies as specialized intracellular sites of compartmentalization of signaling with major roles in eicosanoid formation within cells engaged in inflammatory, infectious and neoplastic process. |
| doi_str_mv | 10.1016/j.plefa.2011.04.020 |
| format | Article |
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Lately, intracellular compartmentalization of eicosanoid–synthetic machinery has emerged as a key component in the regulation of eicosanoid synthesis and functions. Over the past years substantial progresses have been made demonstrating that precursors and enzymes involved in eicosanoid synthesis localize at lipid bodies (also known as lipid droplets) and lipid bodies are distinct sites for eicosanoid generation. 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| identifier | ISSN: 0952-3278 |
| ispartof | Prostaglandins, leukotrienes and essential fatty acids, 2011-11, Vol.85 (5), p.205-213 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Advanced Basic Science Animals Biological and medical sciences Eicosanoids - biosynthesis Endocrinology & Metabolism Fundamental and applied biological sciences. Psychology Humans Infection - metabolism Inflammation - metabolism Lipid Metabolism - physiology Neoplasms - metabolism Signal Transduction - physiology Subcellular Fractions - metabolism Vertebrates: endocrinology |
| title | Lipid body function in eicosanoid synthesis: An update |
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