Multifaceted link between cancer and inflammation

Increasing evidence from epidemiological, preclinical and clinical studies suggests that dysregulated inflammatory response plays a pivotal role in a multitude of chronic ailments including cancer. The molecular mechanism(s) by which chronic inflammation drives cancer initiation and promotion includ...

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Veröffentlicht in:	Bioscience reports 2012-02, Vol.32 (1), p.1-15
Hauptverfasser:	Sethi, Gautam, Shanmugam, Muthu K, Ramachandran, Lalitha, Kumar, Alan Prem, Tergaonkar, Vinay
Format:	Artikel
Sprache:	eng
Schlagworte:	Arachidonate 5-Lipoxygenase - metabolism Chemokines - metabolism Chronic Disease Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Cytokines - metabolism Gene Expression Regulation, Neoplastic Humans Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Inflammation - metabolism Inflammation Mediators Life Style Matrix Metalloproteinases - metabolism Neoplasms - etiology Neoplasms - genetics Neoplasms - metabolism NF-kappa B - metabolism Oncogenes STAT3 Transcription Factor - metabolism Transcription Factor AP-1 - metabolism Tumor Necrosis Factor-alpha - metabolism
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