Dicaffeoylquinic acids in Yerba mate (Ilex paraguariensis St. Hilaire) inhibit NF-κB nucleus translocation in macrophages and induce apoptosis by activating caspases-8 and -3 in human colon cancer cells

Scope: The biological functions of caffeoylquinic acid (CQA) derivatives from various plant sources have been partially elucidated. The objectives were to isolate and purify diCQAs from Yerba mate tea leaves and assess their anti‐inflammatory and anti‐cancer capabilities in vitro and explore their m...

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Veröffentlicht in:	Molecular nutrition & food research 2011-10, Vol.55 (10), p.1509-1522
Hauptverfasser:	Puangpraphant, Sirima, Berhow, Mark A., Vermillion, Karl, Potts, Greg, Gonzalez de Mejia, Elvira
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects bcl-2-Associated X Protein - metabolism Caspase 3 - metabolism Caspase 8 - metabolism Cell Nucleus - metabolism Cell Proliferation - drug effects Chlorogenic Acid - analogs & derivatives Chlorogenic Acid - isolation & purification Chlorogenic Acid - pharmacology Colon cancer Colonic Neoplasms - drug therapy Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Cyclooxygenase 2 - metabolism Dicaffeoylquinic acids Dinoprostone - metabolism Drug Evaluation, Preclinical Enzyme Activation HT29 Cells Humans Ilex paraguariensis - chemistry Inflammation Lipopolysaccharides - toxicity Macrophages - drug effects Macrophages - metabolism Magnetic Resonance Spectroscopy Mice NF-kappa B - metabolism Nitric Oxide - metabolism Nitric Oxide Synthase Type II - metabolism Plant Extracts - pharmacology Plant Leaves - chemistry Protein Transport Proto-Oncogene Proteins c-bcl-2 - metabolism Yerba mate
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