Dicaffeoylquinic acids in Yerba mate (Ilex paraguariensis St. Hilaire) inhibit NF-κB nucleus translocation in macrophages and induce apoptosis by activating caspases-8 and -3 in human colon cancer cells
Scope: The biological functions of caffeoylquinic acid (CQA) derivatives from various plant sources have been partially elucidated. The objectives were to isolate and purify diCQAs from Yerba mate tea leaves and assess their anti‐inflammatory and anti‐cancer capabilities in vitro and explore their m...
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| Veröffentlicht in: | Molecular nutrition & food research 2011-10, Vol.55 (10), p.1509-1522 |
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| creator | Puangpraphant, Sirima Berhow, Mark A. Vermillion, Karl Potts, Greg Gonzalez de Mejia, Elvira |
| description | Scope: The biological functions of caffeoylquinic acid (CQA) derivatives from various plant sources have been partially elucidated. The objectives were to isolate and purify diCQAs from Yerba mate tea leaves and assess their anti‐inflammatory and anti‐cancer capabilities in vitro and explore their mechanism of action.
Methods and results: Methanol extracts of dried mate leaves were resolved by flash chromatography and further purified resulting in two fractions one containing 3,4‐ and 3,5‐diCQAs and the other 4,5‐diCQA with NMR‐confirmed structures. Both fractions inhibited LPS‐induced RAW 264.7 macrophage inflammation by suppressing nitric oxide/inducible nitric oxide and prostaglandin E2/cyclooxygenase‐2 pathways through inhibiting nucleus translocation of Nuclear factor κB subunits, p50 and p65. The diCQA fractions inhibited Human colon cancer cells CRL‐2577 (RKO) and HT‐29 cell proliferation by inducing apoptosis in a time‐ and concentration‐dependent manner, but did not affect the protein levels of p21, p27, p53, and Bax:Bcl‐2 ratio in RKO cells. In HT‐29 cells, however, the diCQA fractions increased Bax:Bcl‐2 ratio. The diCQA fractions increased the activation of caspase‐8 leading to cleavage of caspase‐3 in both RKO and HT‐29 colon cancer cells.
Conclusion: The results suggest that diCQAs in Yerba mate could be potential anti‐cancer agents and could mitigate other diseases also associated with inflammation. |
| doi_str_mv | 10.1002/mnfr.201100128 |
| format | Article |
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Methods and results: Methanol extracts of dried mate leaves were resolved by flash chromatography and further purified resulting in two fractions one containing 3,4‐ and 3,5‐diCQAs and the other 4,5‐diCQA with NMR‐confirmed structures. Both fractions inhibited LPS‐induced RAW 264.7 macrophage inflammation by suppressing nitric oxide/inducible nitric oxide and prostaglandin E2/cyclooxygenase‐2 pathways through inhibiting nucleus translocation of Nuclear factor κB subunits, p50 and p65. The diCQA fractions inhibited Human colon cancer cells CRL‐2577 (RKO) and HT‐29 cell proliferation by inducing apoptosis in a time‐ and concentration‐dependent manner, but did not affect the protein levels of p21, p27, p53, and Bax:Bcl‐2 ratio in RKO cells. In HT‐29 cells, however, the diCQA fractions increased Bax:Bcl‐2 ratio. The diCQA fractions increased the activation of caspase‐8 leading to cleavage of caspase‐3 in both RKO and HT‐29 colon cancer cells.
Conclusion: The results suggest that diCQAs in Yerba mate could be potential anti‐cancer agents and could mitigate other diseases also associated with inflammation.</description><identifier>ISSN: 1613-4125</identifier><identifier>EISSN: 1613-4133</identifier><identifier>DOI: 10.1002/mnfr.201100128</identifier><identifier>PMID: 21656672</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>Animals ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Antineoplastic Agents, Phytogenic - pharmacology ; Apoptosis ; Apoptosis - drug effects ; bcl-2-Associated X Protein - metabolism ; Caspase 3 - metabolism ; Caspase 8 - metabolism ; Cell Nucleus - metabolism ; Cell Proliferation - drug effects ; Chlorogenic Acid - analogs & derivatives ; Chlorogenic Acid - isolation & purification ; Chlorogenic Acid - pharmacology ; Colon cancer ; Colonic Neoplasms - drug therapy ; Colonic Neoplasms - metabolism ; Colonic Neoplasms - pathology ; Cyclooxygenase 2 - metabolism ; Dicaffeoylquinic acids ; Dinoprostone - metabolism ; Drug Evaluation, Preclinical ; Enzyme Activation ; HT29 Cells ; Humans ; Ilex paraguariensis - chemistry ; Inflammation ; Lipopolysaccharides - toxicity ; Macrophages - drug effects ; Macrophages - metabolism ; Magnetic Resonance Spectroscopy ; Mice ; NF-kappa B - metabolism ; Nitric Oxide - metabolism ; Nitric Oxide Synthase Type II - metabolism ; Plant Extracts - pharmacology ; Plant Leaves - chemistry ; Protein Transport ; Proto-Oncogene Proteins c-bcl-2 - metabolism ; Yerba mate</subject><ispartof>Molecular nutrition & food research, 2011-10, Vol.55 (10), p.1509-1522</ispartof><rights>Copyright © 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3828-a027dc8f0d716b8ee26dde60347091708ab3a6e3d19074b16fde183a8dad54073</citedby><cites>FETCH-LOGICAL-c3828-a027dc8f0d716b8ee26dde60347091708ab3a6e3d19074b16fde183a8dad54073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmnfr.201100128$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmnfr.201100128$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21656672$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Puangpraphant, Sirima</creatorcontrib><creatorcontrib>Berhow, Mark A.</creatorcontrib><creatorcontrib>Vermillion, Karl</creatorcontrib><creatorcontrib>Potts, Greg</creatorcontrib><creatorcontrib>Gonzalez de Mejia, Elvira</creatorcontrib><title>Dicaffeoylquinic acids in Yerba mate (Ilex paraguariensis St. Hilaire) inhibit NF-κB nucleus translocation in macrophages and induce apoptosis by activating caspases-8 and -3 in human colon cancer cells</title><title>Molecular nutrition & food research</title><addtitle>Mol. Nutr. Food Res</addtitle><description>Scope: The biological functions of caffeoylquinic acid (CQA) derivatives from various plant sources have been partially elucidated. The objectives were to isolate and purify diCQAs from Yerba mate tea leaves and assess their anti‐inflammatory and anti‐cancer capabilities in vitro and explore their mechanism of action.
Methods and results: Methanol extracts of dried mate leaves were resolved by flash chromatography and further purified resulting in two fractions one containing 3,4‐ and 3,5‐diCQAs and the other 4,5‐diCQA with NMR‐confirmed structures. Both fractions inhibited LPS‐induced RAW 264.7 macrophage inflammation by suppressing nitric oxide/inducible nitric oxide and prostaglandin E2/cyclooxygenase‐2 pathways through inhibiting nucleus translocation of Nuclear factor κB subunits, p50 and p65. The diCQA fractions inhibited Human colon cancer cells CRL‐2577 (RKO) and HT‐29 cell proliferation by inducing apoptosis in a time‐ and concentration‐dependent manner, but did not affect the protein levels of p21, p27, p53, and Bax:Bcl‐2 ratio in RKO cells. In HT‐29 cells, however, the diCQA fractions increased Bax:Bcl‐2 ratio. The diCQA fractions increased the activation of caspase‐8 leading to cleavage of caspase‐3 in both RKO and HT‐29 colon cancer cells.
Conclusion: The results suggest that diCQAs in Yerba mate could be potential anti‐cancer agents and could mitigate other diseases also associated with inflammation.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>bcl-2-Associated X Protein - metabolism</subject><subject>Caspase 3 - metabolism</subject><subject>Caspase 8 - metabolism</subject><subject>Cell Nucleus - metabolism</subject><subject>Cell Proliferation - drug effects</subject><subject>Chlorogenic Acid - analogs & derivatives</subject><subject>Chlorogenic Acid - isolation & purification</subject><subject>Chlorogenic Acid - pharmacology</subject><subject>Colon cancer</subject><subject>Colonic Neoplasms - drug therapy</subject><subject>Colonic Neoplasms - metabolism</subject><subject>Colonic Neoplasms - pathology</subject><subject>Cyclooxygenase 2 - metabolism</subject><subject>Dicaffeoylquinic acids</subject><subject>Dinoprostone - metabolism</subject><subject>Drug Evaluation, Preclinical</subject><subject>Enzyme Activation</subject><subject>HT29 Cells</subject><subject>Humans</subject><subject>Ilex paraguariensis - chemistry</subject><subject>Inflammation</subject><subject>Lipopolysaccharides - toxicity</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - metabolism</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Mice</subject><subject>NF-kappa B - metabolism</subject><subject>Nitric Oxide - metabolism</subject><subject>Nitric Oxide Synthase Type II - metabolism</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Leaves - chemistry</subject><subject>Protein Transport</subject><subject>Proto-Oncogene Proteins c-bcl-2 - metabolism</subject><subject>Yerba mate</subject><issn>1613-4125</issn><issn>1613-4133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcuO0zAUhiMEYi6wZYm8AxYpviROsmQK7cyoFInhIlbWiX3SGhInYyfD9NV4BSSeiYQOFTtWvuj7P52jP4qeMDpjlPKXjav8jFM2PhjP70XHTDIRJ0yI-4c7T4-ikxC-UioYT8TD6IgzmUqZ8ePo52uroaqw3dXXg3VWE9DWBGId-YK-BNJAj-T5RY23pAMPmwG8RRdsIFf9jJzbGqzHFyO_taXtyXoR__pxRtygaxwC6T24ULcaetu6SdqA9m23hQ0GAs6MX2bQSKBru76drOVunKC3N2PCbYiG0EHAEOd_6FhMju3QgCO6rUelBqfRE411HR5FDyqoAz6-O0-jj4s3H-bn8erd8mL-ahVrkfM8Bsozo_OKmozJMkfk0hiUVCQZLVhGcygFSBSGFTRLSiYrgywXkBswaUIzcRo923s7314PGHrV2DBNAA7bIaiCCilZkfKRnO3JcekQPFaq87YBv1OMqqk_NfWnDv2Ngad36qFs0Bzwv4WNQLEHvtsad__Rqbfrxft_5fE-a0OPt4cs-G9KZiJL1ef1UrHlcvXp8vJKzcVvUly6cw</recordid><startdate>201110</startdate><enddate>201110</enddate><creator>Puangpraphant, Sirima</creator><creator>Berhow, Mark A.</creator><creator>Vermillion, Karl</creator><creator>Potts, Greg</creator><creator>Gonzalez de Mejia, Elvira</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201110</creationdate><title>Dicaffeoylquinic acids in Yerba mate (Ilex paraguariensis St. Hilaire) inhibit NF-κB nucleus translocation in macrophages and induce apoptosis by activating caspases-8 and -3 in human colon cancer cells</title><author>Puangpraphant, Sirima ; Berhow, Mark A. ; Vermillion, Karl ; Potts, Greg ; Gonzalez de Mejia, Elvira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3828-a027dc8f0d716b8ee26dde60347091708ab3a6e3d19074b16fde183a8dad54073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>bcl-2-Associated X Protein - metabolism</topic><topic>Caspase 3 - metabolism</topic><topic>Caspase 8 - metabolism</topic><topic>Cell Nucleus - metabolism</topic><topic>Cell Proliferation - drug effects</topic><topic>Chlorogenic Acid - analogs & derivatives</topic><topic>Chlorogenic Acid - isolation & purification</topic><topic>Chlorogenic Acid - pharmacology</topic><topic>Colon cancer</topic><topic>Colonic Neoplasms - drug therapy</topic><topic>Colonic Neoplasms - metabolism</topic><topic>Colonic Neoplasms - pathology</topic><topic>Cyclooxygenase 2 - metabolism</topic><topic>Dicaffeoylquinic acids</topic><topic>Dinoprostone - metabolism</topic><topic>Drug Evaluation, Preclinical</topic><topic>Enzyme Activation</topic><topic>HT29 Cells</topic><topic>Humans</topic><topic>Ilex paraguariensis - chemistry</topic><topic>Inflammation</topic><topic>Lipopolysaccharides - toxicity</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - metabolism</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Mice</topic><topic>NF-kappa B - metabolism</topic><topic>Nitric Oxide - metabolism</topic><topic>Nitric Oxide Synthase Type II - metabolism</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Leaves - chemistry</topic><topic>Protein Transport</topic><topic>Proto-Oncogene Proteins c-bcl-2 - metabolism</topic><topic>Yerba mate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Puangpraphant, Sirima</creatorcontrib><creatorcontrib>Berhow, Mark A.</creatorcontrib><creatorcontrib>Vermillion, Karl</creatorcontrib><creatorcontrib>Potts, Greg</creatorcontrib><creatorcontrib>Gonzalez de Mejia, Elvira</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular nutrition & food research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Puangpraphant, Sirima</au><au>Berhow, Mark A.</au><au>Vermillion, Karl</au><au>Potts, Greg</au><au>Gonzalez de Mejia, Elvira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dicaffeoylquinic acids in Yerba mate (Ilex paraguariensis St. Hilaire) inhibit NF-κB nucleus translocation in macrophages and induce apoptosis by activating caspases-8 and -3 in human colon cancer cells</atitle><jtitle>Molecular nutrition & food research</jtitle><addtitle>Mol. Nutr. Food Res</addtitle><date>2011-10</date><risdate>2011</risdate><volume>55</volume><issue>10</issue><spage>1509</spage><epage>1522</epage><pages>1509-1522</pages><issn>1613-4125</issn><eissn>1613-4133</eissn><abstract>Scope: The biological functions of caffeoylquinic acid (CQA) derivatives from various plant sources have been partially elucidated. The objectives were to isolate and purify diCQAs from Yerba mate tea leaves and assess their anti‐inflammatory and anti‐cancer capabilities in vitro and explore their mechanism of action.
Methods and results: Methanol extracts of dried mate leaves were resolved by flash chromatography and further purified resulting in two fractions one containing 3,4‐ and 3,5‐diCQAs and the other 4,5‐diCQA with NMR‐confirmed structures. Both fractions inhibited LPS‐induced RAW 264.7 macrophage inflammation by suppressing nitric oxide/inducible nitric oxide and prostaglandin E2/cyclooxygenase‐2 pathways through inhibiting nucleus translocation of Nuclear factor κB subunits, p50 and p65. The diCQA fractions inhibited Human colon cancer cells CRL‐2577 (RKO) and HT‐29 cell proliferation by inducing apoptosis in a time‐ and concentration‐dependent manner, but did not affect the protein levels of p21, p27, p53, and Bax:Bcl‐2 ratio in RKO cells. In HT‐29 cells, however, the diCQA fractions increased Bax:Bcl‐2 ratio. The diCQA fractions increased the activation of caspase‐8 leading to cleavage of caspase‐3 in both RKO and HT‐29 colon cancer cells.
Conclusion: The results suggest that diCQAs in Yerba mate could be potential anti‐cancer agents and could mitigate other diseases also associated with inflammation.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><pmid>21656672</pmid><doi>10.1002/mnfr.201100128</doi><tpages>14</tpages></addata></record> |
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| subjects | Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects bcl-2-Associated X Protein - metabolism Caspase 3 - metabolism Caspase 8 - metabolism Cell Nucleus - metabolism Cell Proliferation - drug effects Chlorogenic Acid - analogs & derivatives Chlorogenic Acid - isolation & purification Chlorogenic Acid - pharmacology Colon cancer Colonic Neoplasms - drug therapy Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Cyclooxygenase 2 - metabolism Dicaffeoylquinic acids Dinoprostone - metabolism Drug Evaluation, Preclinical Enzyme Activation HT29 Cells Humans Ilex paraguariensis - chemistry Inflammation Lipopolysaccharides - toxicity Macrophages - drug effects Macrophages - metabolism Magnetic Resonance Spectroscopy Mice NF-kappa B - metabolism Nitric Oxide - metabolism Nitric Oxide Synthase Type II - metabolism Plant Extracts - pharmacology Plant Leaves - chemistry Protein Transport Proto-Oncogene Proteins c-bcl-2 - metabolism Yerba mate |
| title | Dicaffeoylquinic acids in Yerba mate (Ilex paraguariensis St. Hilaire) inhibit NF-κB nucleus translocation in macrophages and induce apoptosis by activating caspases-8 and -3 in human colon cancer cells |
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