Alpha- and beta-adrenergic receptor (AR) protein expression is associated with poor clinical outcome in breast cancer: an immunohistochemical study

Breast cancer mortality is frequently associated with metastatic disease. Metastasis models have shown adrenoceptor (AR) stimulation induces cell migration which is inhibited by adrenoceptor antagonist drugs. We investigated adrenoceptor protein expression in clinical breast tumours and its associat...

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Veröffentlicht in:	Breast cancer research and treatment 2011-11, Vol.130 (2), p.457-463
Hauptverfasser:	Powe, D. G., Voss, M. J., Habashy, H. O., Zänker, K. S., Green, A. R., Ellis, I. O., Entschladen, F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Biomarkers Biomarkers, Tumor - metabolism Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Cancer Cancer research Cancer therapies Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - mortality Carcinoma, Ductal, Breast - secondary Carcinoma, Lobular - metabolism Carcinoma, Lobular - mortality Carcinoma, Lobular - secondary Clinical outcomes Disease-Free Survival Female Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Kaplan-Meier Estimate Mammary gland diseases Medical sciences Medicine Medicine & Public Health Middle Aged Neoplasm Grading Oncology Oncology, Experimental Patient outcomes Preclinical Study Prognosis Receptors, Adrenergic, alpha-1 - metabolism Receptors, Adrenergic, alpha-2 - metabolism Receptors, Adrenergic, beta-2 - metabolism Receptors, Estrogen - metabolism Tumor Burden Tumor proteins Tumors
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