A double-blind, randomized, controlled, multicenter study to assess the safety and cardiovascular effects of skeletal myoblast implantation by catheter delivery in patients with chronic heart failure after myocardial infarction

Background We sought to determine the safety and preliminary efficacy of transcatheter intramyocardial administration of myoblasts in patients with heart failure (HF). Methods MARVEL is a randomized placebo-controlled trial of image-guided, catheter-based intramyocardial injection of placebo or myob...

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Veröffentlicht in:	The American heart journal 2011-10, Vol.162 (4), p.654-662.e1
Hauptverfasser:	Povsic, Thomas J., MD, PhD, FACC, O'Connor, Christopher M., MD, FACC, Henry, Timothy, MD, FACC, Taussig, Andrew, MD, FACC, Kereiakes, Dean J., MD, FACC, Fortuin, F. David, MD, FACC, Niederman, Alan, MD, FACC, Schatz, Richard, MD, FACC, Spencer, Richard, JD, Owens, Douglas, RN, Banks, Missy, BA, Joseph, Diane, BS, Roberts, Rhonda, MSPH, Alexander, John H., MD, MHS, FACC, Sherman, Warren, MD, FACC
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Angina pectoris Biological and medical sciences Cardiac Catheterization Cardiac Surgical Procedures - adverse effects Cardiac Surgical Procedures - methods Cardiology Cardiology. Vascular system Cardiovascular Chronic Disease Coronary heart disease Coronary vessels Delivery. Postpartum. Lactation Double-Blind Method Female Gynecology. Andrology. Obstetrics Heart Heart attacks Heart Failure - etiology Heart Failure - surgery Heart failure, cardiogenic pulmonary edema, cardiac enlargement Humans Male Medical sciences Middle Aged Myoblasts, Skeletal - transplantation Myocardial Infarction - complications Myocarditis. Cardiomyopathies
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Beschreibung
Zusammenfassung:	Background We sought to determine the safety and preliminary efficacy of transcatheter intramyocardial administration of myoblasts in patients with heart failure (HF). Methods MARVEL is a randomized placebo-controlled trial of image-guided, catheter-based intramyocardial injection of placebo or myoblasts (400 or 800 million) in patients with class II to IV HF and ejection fraction
ISSN:	0002-8703 1097-6744
DOI:	10.1016/j.ahj.2011.07.020