Oxidative stress is implicated in arsenic-induced neural tube defects in chick embryos

• Arsenic-induced neural tube defects were associated with oxidative stress. • NAC partially rescued arsenic-induced oxidative stress. • NAC ameliorated arsenic-induced DNA hypomethylation. • Arsenic induced alteration in SAM and SAH. The potential of arsenic to induce neural tube defects (NTDs) rem...

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Veröffentlicht in:	International journal of developmental neuroscience 2011-11, Vol.29 (7), p.673-680
Hauptverfasser:	Han, Zhong-Ji, Song, Ge, Cui, Yi, Xia, Hong-Fei, Ma, Xu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Animal models Animals Arsenic - pharmacology Chick Embryo - abnormalities Chick Embryo - drug effects DNA hypomethylation Epigenesis, Genetic Epigenetic Female Glutathione Peroxidase - metabolism Malondialdehyde - metabolism Neural tube defects Neural Tube Defects - chemically induced Oxidative stress Oxidative Stress - drug effects Reactive Oxygen Species - metabolism S-Adenosylhomocysteine - metabolism S-Adenosylmethionine - metabolism Sodium arsenite Superoxide Dismutase - metabolism
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