Chlorella vulgaris restores bone marrow cellularity and cytokine production in lead-exposed mice
► We evaluated the immunoprotective effects of CV in lead-exposed mice. ► c-Kit+Lin− and Gr1+Mac+ hematopoietic cells, and total cellularity were examined. ► NK cell activity and production of IL-1α, TNF-α, IFN-γ, IL-10, IL-6 were evaluated. ► CV recovered the reduced numbers of hematopoietic cell p...
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| Veröffentlicht in: | Food and chemical toxicology 2011-11, Vol.49 (11), p.2934-2941 |
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| creator | Queiroz, Mary L.S. da Rocha, Michelle C. Torello, Cristiane O. de Souza Queiroz, Julia Bincoletto, Claudia Morgano, Marcelo A. Romano, Miriam R. Paredes-Gamero, Edgar J. Barbosa, Christiano M.V. Calgarotto, Andrana K. |
| description | ► We evaluated the immunoprotective effects of CV in lead-exposed mice. ► c-Kit+Lin− and Gr1+Mac+ hematopoietic cells, and total cellularity were examined. ► NK cell activity and production of IL-1α, TNF-α, IFN-γ, IL-10, IL-6 were evaluated. ► CV recovered the reduced numbers of hematopoietic cell populations in Pb-exposed mice. ► CV modulated NK cells activity and the production of IFN-γ, IL-1α, TNF-α, IL-10 and IL-6.
Chlorella vulgaris (CV) was examined for its modulating effects on the reduction induced by lead (Pb) on the numbers of marrow hematopoietic stem cells (HSCs) (c-Kit+Lin−), granulocyte–macrophage progenitors (Gr1+Mac1+) and total bone marrow cellularity. In mice gavage-treated daily with 50mg/kg dose of CV for 10days, concomitant to a continuous offering of 1300ppm lead acetate in drinking water, the treatment with the algae recovered the significantly reduced numbers of these cell populations to control values. As CV may have a myelostimulating effect through the induction of cytokines, we evaluated its modulating effects on the production of IL-1α, TNF-α, IFN-γ, IL-10 and IL-6. Our results demonstrated that lead significantly impairs the production of IFN-γ, IL-1α and TNF-α and increases the production of IL-10 and IL-6 and that these effects are successfully modulated by the CV treatment. The activity of NK cells, reduced in Pb-exposed animals, was raised to levels higher than those of controls in the exposed group treated with CV. Treatment with the algae also stimulated the production of IFN-γ, IL-1α, TNF-α and NK cells activity in normal mice. In addition, zinc bone concentrations, reduced in lead-exposed mice, were partially, but significantly, reversed by the treatment with CV. |
| doi_str_mv | 10.1016/j.fct.2011.06.056 |
| format | Article |
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Chlorella vulgaris (CV) was examined for its modulating effects on the reduction induced by lead (Pb) on the numbers of marrow hematopoietic stem cells (HSCs) (c-Kit+Lin−), granulocyte–macrophage progenitors (Gr1+Mac1+) and total bone marrow cellularity. In mice gavage-treated daily with 50mg/kg dose of CV for 10days, concomitant to a continuous offering of 1300ppm lead acetate in drinking water, the treatment with the algae recovered the significantly reduced numbers of these cell populations to control values. As CV may have a myelostimulating effect through the induction of cytokines, we evaluated its modulating effects on the production of IL-1α, TNF-α, IFN-γ, IL-10 and IL-6. Our results demonstrated that lead significantly impairs the production of IFN-γ, IL-1α and TNF-α and increases the production of IL-10 and IL-6 and that these effects are successfully modulated by the CV treatment. The activity of NK cells, reduced in Pb-exposed animals, was raised to levels higher than those of controls in the exposed group treated with CV. Treatment with the algae also stimulated the production of IFN-γ, IL-1α, TNF-α and NK cells activity in normal mice. In addition, zinc bone concentrations, reduced in lead-exposed mice, were partially, but significantly, reversed by the treatment with CV.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/j.fct.2011.06.056</identifier><identifier>PMID: 21820028</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Biological and medical sciences ; bone marrow ; Bone Marrow Cells - drug effects ; Bone Marrow Cells - physiology ; Cell Proliferation ; Chemical and industrial products toxicology. Toxic occupational diseases ; Chlorella vulgaris ; Cytokines ; Cytokines - genetics ; Cytokines - metabolism ; drinking water ; Gene Expression Regulation - drug effects ; Hematopoiesis ; interferon-gamma ; interleukin-10 ; interleukin-1alpha ; interleukin-6 ; Killer Cells, Natural - drug effects ; Killer Cells, Natural - physiology ; lead ; Lead - toxicity ; Lead acetate ; Male ; Medical sciences ; Metals and various inorganic compounds ; Mice ; Mice, Inbred BALB C ; Natural killer cells ; Phytotherapy ; stem cells ; Toxicology ; tumor necrosis factor-alpha ; Zinc ; Zinc concentrations</subject><ispartof>Food and chemical toxicology, 2011-11, Vol.49 (11), p.2934-2941</ispartof><rights>2011 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-420c2ec39dfb599a35c552a164362ecfeb2c2b4b4a1a365a18d22fef9712cdc83</citedby><cites>FETCH-LOGICAL-c481t-420c2ec39dfb599a35c552a164362ecfeb2c2b4b4a1a365a18d22fef9712cdc83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0278691511003000$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24628642$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21820028$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Queiroz, Mary L.S.</creatorcontrib><creatorcontrib>da Rocha, Michelle C.</creatorcontrib><creatorcontrib>Torello, Cristiane O.</creatorcontrib><creatorcontrib>de Souza Queiroz, Julia</creatorcontrib><creatorcontrib>Bincoletto, Claudia</creatorcontrib><creatorcontrib>Morgano, Marcelo A.</creatorcontrib><creatorcontrib>Romano, Miriam R.</creatorcontrib><creatorcontrib>Paredes-Gamero, Edgar J.</creatorcontrib><creatorcontrib>Barbosa, Christiano M.V.</creatorcontrib><creatorcontrib>Calgarotto, Andrana K.</creatorcontrib><title>Chlorella vulgaris restores bone marrow cellularity and cytokine production in lead-exposed mice</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>► We evaluated the immunoprotective effects of CV in lead-exposed mice. ► c-Kit+Lin− and Gr1+Mac+ hematopoietic cells, and total cellularity were examined. ► NK cell activity and production of IL-1α, TNF-α, IFN-γ, IL-10, IL-6 were evaluated. ► CV recovered the reduced numbers of hematopoietic cell populations in Pb-exposed mice. ► CV modulated NK cells activity and the production of IFN-γ, IL-1α, TNF-α, IL-10 and IL-6.
Chlorella vulgaris (CV) was examined for its modulating effects on the reduction induced by lead (Pb) on the numbers of marrow hematopoietic stem cells (HSCs) (c-Kit+Lin−), granulocyte–macrophage progenitors (Gr1+Mac1+) and total bone marrow cellularity. In mice gavage-treated daily with 50mg/kg dose of CV for 10days, concomitant to a continuous offering of 1300ppm lead acetate in drinking water, the treatment with the algae recovered the significantly reduced numbers of these cell populations to control values. As CV may have a myelostimulating effect through the induction of cytokines, we evaluated its modulating effects on the production of IL-1α, TNF-α, IFN-γ, IL-10 and IL-6. Our results demonstrated that lead significantly impairs the production of IFN-γ, IL-1α and TNF-α and increases the production of IL-10 and IL-6 and that these effects are successfully modulated by the CV treatment. The activity of NK cells, reduced in Pb-exposed animals, was raised to levels higher than those of controls in the exposed group treated with CV. Treatment with the algae also stimulated the production of IFN-γ, IL-1α, TNF-α and NK cells activity in normal mice. In addition, zinc bone concentrations, reduced in lead-exposed mice, were partially, but significantly, reversed by the treatment with CV.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>bone marrow</subject><subject>Bone Marrow Cells - drug effects</subject><subject>Bone Marrow Cells - physiology</subject><subject>Cell Proliferation</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Chlorella vulgaris</subject><subject>Cytokines</subject><subject>Cytokines - genetics</subject><subject>Cytokines - metabolism</subject><subject>drinking water</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Hematopoiesis</subject><subject>interferon-gamma</subject><subject>interleukin-10</subject><subject>interleukin-1alpha</subject><subject>interleukin-6</subject><subject>Killer Cells, Natural - drug effects</subject><subject>Killer Cells, Natural - physiology</subject><subject>lead</subject><subject>Lead - toxicity</subject><subject>Lead acetate</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Natural killer cells</subject><subject>Phytotherapy</subject><subject>stem cells</subject><subject>Toxicology</subject><subject>tumor necrosis factor-alpha</subject><subject>Zinc</subject><subject>Zinc concentrations</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkT-P1DAQxS0E4paDD0ADbhBVgseO7URUpxX_pJMo4Grj2JPDSzZe7ORgvz2OdoEOUVma-c34zXuEPAVWAwP1alcPbq45A6iZqplU98gGWi0qJSTcJxvGdVupDuQFeZTzjjGmQauH5IJDyxnj7YZ82X4dY8JxtPRuGW9tCpkmzHOpZdrHCenephR_UFeYZSz9-Ujt5Kk7zvFbKP1Din5xc4gTDRMd0foKfx5iRk_3weFj8mCwY8Yn5_eS3Lx983n7vrr--O7D9uq6ck0Lc9Vw5jg60fmhl11nhXRScguqEarUB-y5433TNxasUNJC6zkfcOg0cOddKy7Jy9Peouf7Ui4w-5BX0XbCuGTTsTKmhZb_QXKhO9GuO-FEuhRzTjiYQwrFj6MBZtYEzM6UBMyagGHKlATKzLPz9qXfo_8z8dvyArw4AzY7Ow7JTi7kv1yjeKsaXrjnJ26w0djbEoy5-VR-koyBBiXXQ16fCCy-3gVMJruAk0MfEhZZPoZ_CP0FvXKt5A</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>Queiroz, Mary L.S.</creator><creator>da Rocha, Michelle C.</creator><creator>Torello, Cristiane O.</creator><creator>de Souza Queiroz, Julia</creator><creator>Bincoletto, Claudia</creator><creator>Morgano, Marcelo A.</creator><creator>Romano, Miriam R.</creator><creator>Paredes-Gamero, Edgar J.</creator><creator>Barbosa, Christiano M.V.</creator><creator>Calgarotto, Andrana K.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20111101</creationdate><title>Chlorella vulgaris restores bone marrow cellularity and cytokine production in lead-exposed mice</title><author>Queiroz, Mary L.S. ; da Rocha, Michelle C. ; Torello, Cristiane O. ; de Souza Queiroz, Julia ; Bincoletto, Claudia ; Morgano, Marcelo A. ; Romano, Miriam R. ; Paredes-Gamero, Edgar J. ; Barbosa, Christiano M.V. ; Calgarotto, Andrana K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-420c2ec39dfb599a35c552a164362ecfeb2c2b4b4a1a365a18d22fef9712cdc83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>bone marrow</topic><topic>Bone Marrow Cells - drug effects</topic><topic>Bone Marrow Cells - physiology</topic><topic>Cell Proliferation</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Chlorella vulgaris</topic><topic>Cytokines</topic><topic>Cytokines - genetics</topic><topic>Cytokines - metabolism</topic><topic>drinking water</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Hematopoiesis</topic><topic>interferon-gamma</topic><topic>interleukin-10</topic><topic>interleukin-1alpha</topic><topic>interleukin-6</topic><topic>Killer Cells, Natural - drug effects</topic><topic>Killer Cells, Natural - physiology</topic><topic>lead</topic><topic>Lead - toxicity</topic><topic>Lead acetate</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Natural killer cells</topic><topic>Phytotherapy</topic><topic>stem cells</topic><topic>Toxicology</topic><topic>tumor necrosis factor-alpha</topic><topic>Zinc</topic><topic>Zinc concentrations</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Queiroz, Mary L.S.</creatorcontrib><creatorcontrib>da Rocha, Michelle C.</creatorcontrib><creatorcontrib>Torello, Cristiane O.</creatorcontrib><creatorcontrib>de Souza Queiroz, Julia</creatorcontrib><creatorcontrib>Bincoletto, Claudia</creatorcontrib><creatorcontrib>Morgano, Marcelo A.</creatorcontrib><creatorcontrib>Romano, Miriam R.</creatorcontrib><creatorcontrib>Paredes-Gamero, Edgar J.</creatorcontrib><creatorcontrib>Barbosa, Christiano M.V.</creatorcontrib><creatorcontrib>Calgarotto, Andrana K.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Queiroz, Mary L.S.</au><au>da Rocha, Michelle C.</au><au>Torello, Cristiane O.</au><au>de Souza Queiroz, Julia</au><au>Bincoletto, Claudia</au><au>Morgano, Marcelo A.</au><au>Romano, Miriam R.</au><au>Paredes-Gamero, Edgar J.</au><au>Barbosa, Christiano M.V.</au><au>Calgarotto, Andrana K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chlorella vulgaris restores bone marrow cellularity and cytokine production in lead-exposed mice</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2011-11-01</date><risdate>2011</risdate><volume>49</volume><issue>11</issue><spage>2934</spage><epage>2941</epage><pages>2934-2941</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>► We evaluated the immunoprotective effects of CV in lead-exposed mice. ► c-Kit+Lin− and Gr1+Mac+ hematopoietic cells, and total cellularity were examined. ► NK cell activity and production of IL-1α, TNF-α, IFN-γ, IL-10, IL-6 were evaluated. ► CV recovered the reduced numbers of hematopoietic cell populations in Pb-exposed mice. ► CV modulated NK cells activity and the production of IFN-γ, IL-1α, TNF-α, IL-10 and IL-6.
Chlorella vulgaris (CV) was examined for its modulating effects on the reduction induced by lead (Pb) on the numbers of marrow hematopoietic stem cells (HSCs) (c-Kit+Lin−), granulocyte–macrophage progenitors (Gr1+Mac1+) and total bone marrow cellularity. In mice gavage-treated daily with 50mg/kg dose of CV for 10days, concomitant to a continuous offering of 1300ppm lead acetate in drinking water, the treatment with the algae recovered the significantly reduced numbers of these cell populations to control values. As CV may have a myelostimulating effect through the induction of cytokines, we evaluated its modulating effects on the production of IL-1α, TNF-α, IFN-γ, IL-10 and IL-6. Our results demonstrated that lead significantly impairs the production of IFN-γ, IL-1α and TNF-α and increases the production of IL-10 and IL-6 and that these effects are successfully modulated by the CV treatment. The activity of NK cells, reduced in Pb-exposed animals, was raised to levels higher than those of controls in the exposed group treated with CV. Treatment with the algae also stimulated the production of IFN-γ, IL-1α, TNF-α and NK cells activity in normal mice. In addition, zinc bone concentrations, reduced in lead-exposed mice, were partially, but significantly, reversed by the treatment with CV.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>21820028</pmid><doi>10.1016/j.fct.2011.06.056</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biological and medical sciences bone marrow Bone Marrow Cells - drug effects Bone Marrow Cells - physiology Cell Proliferation Chemical and industrial products toxicology. Toxic occupational diseases Chlorella vulgaris Cytokines Cytokines - genetics Cytokines - metabolism drinking water Gene Expression Regulation - drug effects Hematopoiesis interferon-gamma interleukin-10 interleukin-1alpha interleukin-6 Killer Cells, Natural - drug effects Killer Cells, Natural - physiology lead Lead - toxicity Lead acetate Male Medical sciences Metals and various inorganic compounds Mice Mice, Inbred BALB C Natural killer cells Phytotherapy stem cells Toxicology tumor necrosis factor-alpha Zinc Zinc concentrations |
| title | Chlorella vulgaris restores bone marrow cellularity and cytokine production in lead-exposed mice |
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