Shape memory polymer foams for cerebral aneurysm reparation: Effects of plasma sterilization on physical properties and cytocompatibility
Shape memory polyurethanes (SMPUs) represent promising candidate materials for aneurysm embolization, since they could enable clinical problems still associated with these clinical procedures to be overcome. In this work, we report on the characterization of physicochemical, thermomechanical and in...
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| Veröffentlicht in: | Acta biomaterialia 2009-06, Vol.5 (5), p.1508-1518 |
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| creator | De Nardo, Luigi Alberti, Rachele Cigada, Alberto Yahia, L’Hocine Tanzi, Maria Cristina Farè, Silvia |
| description | Shape memory polyurethanes (SMPUs) represent promising candidate materials for aneurysm embolization, since they could enable clinical problems still associated with these clinical procedures to be overcome. In this work, we report on the characterization of physicochemical, thermomechanical and
in vitro interface properties of two SMPU foams (Cold Hibernated Elastic Memory, CHEM), proposed as a material for embolization devices in minimally invasive procedures. Moreover, because device sterilization is mandatory for in vivo applications, effects on the properties of the foams after plasma sterilization were also evaluated. Both foams (CHEM 3520 and CHEM 5520) showed excellent shape recovery ability (recovery rate,
R
r
, up to 99%) in conventional shape recovery tests, performed at constant heating rate. Transition temperatures (
T
trans
), determined by tan
δ peaks in dynamic mechanical analysis (DMA), were 32.2 and 45.1
°C, for CHEM 3520 and 5520, respectively. The value of
T
trans
affects shape memory ability in the recovery test at 37
°C, which simulates the behavior after implantation of the device: in fact,
R
r
was significantly higher for lower
T
trans
foam (
R
r
≈
82% and
R
r
≈
46%, respectively, for CHEM 3520 and CHEM 5520). After plasma sterilization performed by a Sterrad
® sterilization system, an increase in open porosity was observed: this is probably due to the sterilization cycle; however, no effects on shape recovery behavior were observed. Furthermore, plasma treatment had no significant effect on L929 cells in
in vitro cytotoxicity tests, performed on cell culture medium extracts in contact with foams for up to 7 days. Moreover, direct cytocompatibility tests showed a good colonization and growth from L929 cells on CHEM foams, suggesting the effectiveness of an in vivo healing process. All these results seem to suggest that CHEM foams could be advantageously used for manufacturing devices for mini-invasive embolization procedures of aneurysms. |
| doi_str_mv | 10.1016/j.actbio.2008.11.017 |
| format | Article |
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in vitro interface properties of two SMPU foams (Cold Hibernated Elastic Memory, CHEM), proposed as a material for embolization devices in minimally invasive procedures. Moreover, because device sterilization is mandatory for in vivo applications, effects on the properties of the foams after plasma sterilization were also evaluated. Both foams (CHEM 3520 and CHEM 5520) showed excellent shape recovery ability (recovery rate,
R
r
, up to 99%) in conventional shape recovery tests, performed at constant heating rate. Transition temperatures (
T
trans
), determined by tan
δ peaks in dynamic mechanical analysis (DMA), were 32.2 and 45.1
°C, for CHEM 3520 and 5520, respectively. The value of
T
trans
affects shape memory ability in the recovery test at 37
°C, which simulates the behavior after implantation of the device: in fact,
R
r
was significantly higher for lower
T
trans
foam (
R
r
≈
82% and
R
r
≈
46%, respectively, for CHEM 3520 and CHEM 5520). After plasma sterilization performed by a Sterrad
® sterilization system, an increase in open porosity was observed: this is probably due to the sterilization cycle; however, no effects on shape recovery behavior were observed. Furthermore, plasma treatment had no significant effect on L929 cells in
in vitro cytotoxicity tests, performed on cell culture medium extracts in contact with foams for up to 7 days. Moreover, direct cytocompatibility tests showed a good colonization and growth from L929 cells on CHEM foams, suggesting the effectiveness of an in vivo healing process. All these results seem to suggest that CHEM foams could be advantageously used for manufacturing devices for mini-invasive embolization procedures of aneurysms.</description><identifier>ISSN: 1742-7061</identifier><identifier>EISSN: 1878-7568</identifier><identifier>DOI: 10.1016/j.actbio.2008.11.017</identifier><identifier>PMID: 19136318</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Biocompatible Materials - chemistry ; Biocompatible Materials - pharmacology ; Cell Adhesion - drug effects ; Cell Communication - drug effects ; Cell Line ; Cell Proliferation - drug effects ; Cell Survival - drug effects ; Cytocompatibility ; Fibroblasts - cytology ; Fibroblasts - ultrastructure ; Intracranial Aneurysm - therapy ; Kinetics ; Materials Testing ; Mechanical Phenomena - drug effects ; Mice ; Minimally invasive structures ; Plasma sterilization ; Polyurethane foams ; Polyurethanes - chemistry ; Shape memory polymers ; Sterilization - methods ; Transition Temperature - drug effects</subject><ispartof>Acta biomaterialia, 2009-06, Vol.5 (5), p.1508-1518</ispartof><rights>2008 Acta Materialia Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-6ef4a95495a0bec75b61afcf2b83c6bea5ce00d4073a6eef785fcde90b6890e83</citedby><cites>FETCH-LOGICAL-c454t-6ef4a95495a0bec75b61afcf2b83c6bea5ce00d4073a6eef785fcde90b6890e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1742706108003723$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19136318$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Nardo, Luigi</creatorcontrib><creatorcontrib>Alberti, Rachele</creatorcontrib><creatorcontrib>Cigada, Alberto</creatorcontrib><creatorcontrib>Yahia, L’Hocine</creatorcontrib><creatorcontrib>Tanzi, Maria Cristina</creatorcontrib><creatorcontrib>Farè, Silvia</creatorcontrib><title>Shape memory polymer foams for cerebral aneurysm reparation: Effects of plasma sterilization on physical properties and cytocompatibility</title><title>Acta biomaterialia</title><addtitle>Acta Biomater</addtitle><description>Shape memory polyurethanes (SMPUs) represent promising candidate materials for aneurysm embolization, since they could enable clinical problems still associated with these clinical procedures to be overcome. In this work, we report on the characterization of physicochemical, thermomechanical and
in vitro interface properties of two SMPU foams (Cold Hibernated Elastic Memory, CHEM), proposed as a material for embolization devices in minimally invasive procedures. Moreover, because device sterilization is mandatory for in vivo applications, effects on the properties of the foams after plasma sterilization were also evaluated. Both foams (CHEM 3520 and CHEM 5520) showed excellent shape recovery ability (recovery rate,
R
r
, up to 99%) in conventional shape recovery tests, performed at constant heating rate. Transition temperatures (
T
trans
), determined by tan
δ peaks in dynamic mechanical analysis (DMA), were 32.2 and 45.1
°C, for CHEM 3520 and 5520, respectively. The value of
T
trans
affects shape memory ability in the recovery test at 37
°C, which simulates the behavior after implantation of the device: in fact,
R
r
was significantly higher for lower
T
trans
foam (
R
r
≈
82% and
R
r
≈
46%, respectively, for CHEM 3520 and CHEM 5520). After plasma sterilization performed by a Sterrad
® sterilization system, an increase in open porosity was observed: this is probably due to the sterilization cycle; however, no effects on shape recovery behavior were observed. Furthermore, plasma treatment had no significant effect on L929 cells in
in vitro cytotoxicity tests, performed on cell culture medium extracts in contact with foams for up to 7 days. Moreover, direct cytocompatibility tests showed a good colonization and growth from L929 cells on CHEM foams, suggesting the effectiveness of an in vivo healing process. All these results seem to suggest that CHEM foams could be advantageously used for manufacturing devices for mini-invasive embolization procedures of aneurysms.</description><subject>Animals</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biocompatible Materials - pharmacology</subject><subject>Cell Adhesion - drug effects</subject><subject>Cell Communication - drug effects</subject><subject>Cell Line</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Cytocompatibility</subject><subject>Fibroblasts - cytology</subject><subject>Fibroblasts - ultrastructure</subject><subject>Intracranial Aneurysm - therapy</subject><subject>Kinetics</subject><subject>Materials Testing</subject><subject>Mechanical Phenomena - drug effects</subject><subject>Mice</subject><subject>Minimally invasive structures</subject><subject>Plasma sterilization</subject><subject>Polyurethane foams</subject><subject>Polyurethanes - chemistry</subject><subject>Shape memory polymers</subject><subject>Sterilization - methods</subject><subject>Transition Temperature - drug effects</subject><issn>1742-7061</issn><issn>1878-7568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcuKFDEUhgtRnHH0DUSy0lWVJ5VLpVwIMowXGHChrkMqdcKkqXTKJC2Ub-Bbm7Yb3M1ASLL4_j-Xr2leUugoUPl21xlbJh-7HkB1lHZAh0fNJVWDagch1eO6H3jfDiDpRfMs5x0AU7RXT5sLOlImGVWXzZ9vd2ZFEjDEtJE1LlvARFw0Idc5EYsJp2QWYvZ4SFsOJOFqkik-7t-RG-fQlkyiI-ticjAkF0x-8b__AaSO9W7L3taCNcUVU_GYa9dM7FaijWGt4FQDZXvePHFmyfjivF41Pz7efL_-3N5-_fTl-sNta7ngpZXouBkFH4WBCe0gJkmNs66fFLNyQiMsAswcBmYkohuUcHbGESapRkDFrpo3p956oZ8HzEUHny0uS31hPGQ9ApP82F_J1_eScqDjyMTDIONcgQD6INiDkLJnrIL8BNoUc07o9Jp8MGnTFPRRv97pk3591K8p1VV_jb069x-mgPP_0Nl3Bd6fAKw__Mtj0tl63Fucfaom9Rz9_Sf8BUWpxvM</recordid><startdate>20090601</startdate><enddate>20090601</enddate><creator>De Nardo, Luigi</creator><creator>Alberti, Rachele</creator><creator>Cigada, Alberto</creator><creator>Yahia, L’Hocine</creator><creator>Tanzi, Maria Cristina</creator><creator>Farè, Silvia</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20090601</creationdate><title>Shape memory polymer foams for cerebral aneurysm reparation: Effects of plasma sterilization on physical properties and cytocompatibility</title><author>De Nardo, Luigi ; Alberti, Rachele ; Cigada, Alberto ; Yahia, L’Hocine ; Tanzi, Maria Cristina ; Farè, Silvia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-6ef4a95495a0bec75b61afcf2b83c6bea5ce00d4073a6eef785fcde90b6890e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biocompatible Materials - pharmacology</topic><topic>Cell Adhesion - drug effects</topic><topic>Cell Communication - drug effects</topic><topic>Cell Line</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Cytocompatibility</topic><topic>Fibroblasts - cytology</topic><topic>Fibroblasts - ultrastructure</topic><topic>Intracranial Aneurysm - therapy</topic><topic>Kinetics</topic><topic>Materials Testing</topic><topic>Mechanical Phenomena - drug effects</topic><topic>Mice</topic><topic>Minimally invasive structures</topic><topic>Plasma sterilization</topic><topic>Polyurethane foams</topic><topic>Polyurethanes - chemistry</topic><topic>Shape memory polymers</topic><topic>Sterilization - methods</topic><topic>Transition Temperature - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Nardo, Luigi</creatorcontrib><creatorcontrib>Alberti, Rachele</creatorcontrib><creatorcontrib>Cigada, Alberto</creatorcontrib><creatorcontrib>Yahia, L’Hocine</creatorcontrib><creatorcontrib>Tanzi, Maria Cristina</creatorcontrib><creatorcontrib>Farè, Silvia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Acta biomaterialia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Nardo, Luigi</au><au>Alberti, Rachele</au><au>Cigada, Alberto</au><au>Yahia, L’Hocine</au><au>Tanzi, Maria Cristina</au><au>Farè, Silvia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Shape memory polymer foams for cerebral aneurysm reparation: Effects of plasma sterilization on physical properties and cytocompatibility</atitle><jtitle>Acta biomaterialia</jtitle><addtitle>Acta Biomater</addtitle><date>2009-06-01</date><risdate>2009</risdate><volume>5</volume><issue>5</issue><spage>1508</spage><epage>1518</epage><pages>1508-1518</pages><issn>1742-7061</issn><eissn>1878-7568</eissn><abstract>Shape memory polyurethanes (SMPUs) represent promising candidate materials for aneurysm embolization, since they could enable clinical problems still associated with these clinical procedures to be overcome. In this work, we report on the characterization of physicochemical, thermomechanical and
in vitro interface properties of two SMPU foams (Cold Hibernated Elastic Memory, CHEM), proposed as a material for embolization devices in minimally invasive procedures. Moreover, because device sterilization is mandatory for in vivo applications, effects on the properties of the foams after plasma sterilization were also evaluated. Both foams (CHEM 3520 and CHEM 5520) showed excellent shape recovery ability (recovery rate,
R
r
, up to 99%) in conventional shape recovery tests, performed at constant heating rate. Transition temperatures (
T
trans
), determined by tan
δ peaks in dynamic mechanical analysis (DMA), were 32.2 and 45.1
°C, for CHEM 3520 and 5520, respectively. The value of
T
trans
affects shape memory ability in the recovery test at 37
°C, which simulates the behavior after implantation of the device: in fact,
R
r
was significantly higher for lower
T
trans
foam (
R
r
≈
82% and
R
r
≈
46%, respectively, for CHEM 3520 and CHEM 5520). After plasma sterilization performed by a Sterrad
® sterilization system, an increase in open porosity was observed: this is probably due to the sterilization cycle; however, no effects on shape recovery behavior were observed. Furthermore, plasma treatment had no significant effect on L929 cells in
in vitro cytotoxicity tests, performed on cell culture medium extracts in contact with foams for up to 7 days. Moreover, direct cytocompatibility tests showed a good colonization and growth from L929 cells on CHEM foams, suggesting the effectiveness of an in vivo healing process. All these results seem to suggest that CHEM foams could be advantageously used for manufacturing devices for mini-invasive embolization procedures of aneurysms.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>19136318</pmid><doi>10.1016/j.actbio.2008.11.017</doi><tpages>11</tpages></addata></record> |
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| ispartof | Acta biomaterialia, 2009-06, Vol.5 (5), p.1508-1518 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Cell Adhesion - drug effects Cell Communication - drug effects Cell Line Cell Proliferation - drug effects Cell Survival - drug effects Cytocompatibility Fibroblasts - cytology Fibroblasts - ultrastructure Intracranial Aneurysm - therapy Kinetics Materials Testing Mechanical Phenomena - drug effects Mice Minimally invasive structures Plasma sterilization Polyurethane foams Polyurethanes - chemistry Shape memory polymers Sterilization - methods Transition Temperature - drug effects |
| title | Shape memory polymer foams for cerebral aneurysm reparation: Effects of plasma sterilization on physical properties and cytocompatibility |
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