The use of folate-PEG-grafted-hybranched-PEI nonviral vector for the inhibition of glioma growth in the rat

Abstract Combined treatment using nonviral agent-mediated enzyme/prodrug therapy and immunotherapy had been proposed as a powerful alternative method of cancer therapy. The present study was aimed to evaluate the cytotoxicity in vitro and the therapeutic efficacy in vivo when the cytosine deaminase/...

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Veröffentlicht in:	Biomaterials 2009-08, Vol.30 (23), p.4014-4020
Hauptverfasser:	Liang, Bing, He, Ming-Liang, Chan, Chu-yan, Chen, Yang-chao, Li, Xiang-Ping, Li, Yi, Zheng, Dexian, Lin, Marie C, Kung, Hsiang-Fu, Shuai, Xin-Tao, Peng, Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Brain Neoplasms - therapy Cell Line, Tumor Combined gene therapy Cytosine Deaminase - genetics Cytosine Deaminase - physiology Dentistry Folic Acid - chemistry Genetic Therapy - methods Genetic Vectors - chemistry Glioma Glioma - therapy Immunohistochemistry In vivo gene transfer Male Nonviral vector PEI PEGylation Polyethylene Glycols - chemistry Polyethyleneimine - chemistry Rats Rats, Wistar TNF-Related Apoptosis-Inducing Ligand - genetics TNF-Related Apoptosis-Inducing Ligand - physiology Tumor targeting
Online-Zugang:	Volltext
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