A facile one-pot sonochemical synthesis of surface-coated mannosyl protein microspheres for detection and killing of bacteria

We report a remarkably facile one-pot sonochemical approach to prepare protein microspheres whose shells are covalently decorated with a mannosyl derivative to target Escherichia coli (E. coli), while their cores are encapsulated with tetracycline. Conjugated microspheres induced the agglutination o...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2011-12, Vol.47 (45), p.12277-12279
Hauptverfasser: Skirtenko, Natalia, Richman, Michal, Nitzan, Yeshayahu, Gedanken, Aharon, Rahimipour, Shai
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container_end_page 12279
container_issue 45
container_start_page 12277
container_title Chemical communications (Cambridge, England)
container_volume 47
creator Skirtenko, Natalia
Richman, Michal
Nitzan, Yeshayahu
Gedanken, Aharon
Rahimipour, Shai
description We report a remarkably facile one-pot sonochemical approach to prepare protein microspheres whose shells are covalently decorated with a mannosyl derivative to target Escherichia coli (E. coli), while their cores are encapsulated with tetracycline. Conjugated microspheres induced the agglutination of E. coli and increased the anti-bacterial activity of the encapsulated tetracycline by five fold.
doi_str_mv 10.1039/c1cc13518j
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source MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects Agglutination
Animals
Anti-Bacterial Agents - pharmacology
Bacteria - drug effects
Cattle
Chemical communication
Disulfides - chemistry
Escherichia coli
Escherichia coli - drug effects
Mannose - chemistry
microspheres
Proteins - chemistry
Serum Albumin, Bovine - chemistry
Shells
Tetracycline - pharmacology
Tetracyclines
title A facile one-pot sonochemical synthesis of surface-coated mannosyl protein microspheres for detection and killing of bacteria
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