Ionic-Surfactant-Coated Burkholderia cepacia Lipase as a Highly Active and Enantioselective Catalyst for the Dynamic Kinetic Resolution of Secondary Alcohols
With a coat for activity: A highly active enzyme was prepared by coating Burkholderia cepacia lipase with an ionic surfactant for use in dynamic kinetic resolution (DKR). Important features of this enzyme include: the fastest DKR of 1‐phenylethanol, the highly enantioselective DKR of a wide range of...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2011-11, Vol.50 (46), p.10944-10948 |
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| container_end_page | 10948 |
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| container_issue | 46 |
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| container_title | Angewandte Chemie International Edition |
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| creator | Kim, Hyunjin Choi, Yoon Kyung Lee, Jusuk Lee, Eungyeong Park, Jaiwook Kim, Mahn-Joo |
| description | With a coat for activity: A highly active enzyme was prepared by coating Burkholderia cepacia lipase with an ionic surfactant for use in dynamic kinetic resolution (DKR). Important features of this enzyme include: the fastest DKR of 1‐phenylethanol, the highly enantioselective DKR of a wide range of secondary alcohols (RCH(OH)Ar), and the switching of lipase enantioselectivity in DKR depending on the shape of the aliphatic chain (R). |
| doi_str_mv | 10.1002/anie.201104141 |
| format | Article |
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Important features of this enzyme include: the fastest DKR of 1‐phenylethanol, the highly enantioselective DKR of a wide range of secondary alcohols (RCH(OH)Ar), and the switching of lipase enantioselectivity in DKR depending on the shape of the aliphatic chain (R).</description><edition>International ed. in English</edition><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.201104141</identifier><identifier>PMID: 21954139</identifier><identifier>CODEN: ACIEAY</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>alcohols ; Alcohols - metabolism ; Binding Sites ; Biocatalysis ; Burkholderia cepacia - enzymology ; catalysts ; Catalytic Domain ; dynamic kinetic resolution ; Ions - chemistry ; Kinetics ; Lipase - chemistry ; Lipase - metabolism ; lipases ; ruthenium ; Stereoisomerism ; Surface-Active Agents - chemistry</subject><ispartof>Angewandte Chemie International Edition, 2011-11, Vol.50 (46), p.10944-10948</ispartof><rights>Copyright © 2011 WILEY‐VCH Verlag GmbH & Co. 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Chem. Int. Ed</addtitle><description>With a coat for activity: A highly active enzyme was prepared by coating Burkholderia cepacia lipase with an ionic surfactant for use in dynamic kinetic resolution (DKR). 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Chem. Int. Ed</addtitle><date>2011-11-11</date><risdate>2011</risdate><volume>50</volume><issue>46</issue><spage>10944</spage><epage>10948</epage><pages>10944-10948</pages><issn>1433-7851</issn><eissn>1521-3773</eissn><coden>ACIEAY</coden><abstract>With a coat for activity: A highly active enzyme was prepared by coating Burkholderia cepacia lipase with an ionic surfactant for use in dynamic kinetic resolution (DKR). Important features of this enzyme include: the fastest DKR of 1‐phenylethanol, the highly enantioselective DKR of a wide range of secondary alcohols (RCH(OH)Ar), and the switching of lipase enantioselectivity in DKR depending on the shape of the aliphatic chain (R).</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><pmid>21954139</pmid><doi>10.1002/anie.201104141</doi><tpages>5</tpages><edition>International ed. in English</edition></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1433-7851 |
| ispartof | Angewandte Chemie International Edition, 2011-11, Vol.50 (46), p.10944-10948 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | alcohols Alcohols - metabolism Binding Sites Biocatalysis Burkholderia cepacia - enzymology catalysts Catalytic Domain dynamic kinetic resolution Ions - chemistry Kinetics Lipase - chemistry Lipase - metabolism lipases ruthenium Stereoisomerism Surface-Active Agents - chemistry |
| title | Ionic-Surfactant-Coated Burkholderia cepacia Lipase as a Highly Active and Enantioselective Catalyst for the Dynamic Kinetic Resolution of Secondary Alcohols |
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