Effect of Atorvastatin on Angiogenesis in Degenerated Intervertebral Disc in Rat
An experimental study to measure the depth of penetration of new vessels in degenerated intervertebral disc in rat. To evaluate the effects of atorvastatin on angiogenesis in experimental disc degeneration in rat. Back pain is strongly associated with degenerated intervertebral disc and management o...
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| Veröffentlicht in: | Spine (Philadelphia, Pa. 1976) Pa. 1976), 2011-10, Vol.36 (22), p.1824-1828 |
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| container_title | Spine (Philadelphia, Pa. 1976) |
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| creator | KARAMOUZIAN, Saeid ESKANDARY, Hossein SAEED, Alireza REIHANI-KERMANI, Hamed ABOOSAEEDI, Hamid Reza MALEKPOOR-AFSHAR, Reza SAFIZADE, Hossein ESKANDARI, Mohammad |
| description | An experimental study to measure the depth of penetration of new vessels in degenerated intervertebral disc in rat.
To evaluate the effects of atorvastatin on angiogenesis in experimental disc degeneration in rat.
Back pain is strongly associated with degenerated intervertebral disc and management of this condition is still empirical. Decrease of nucleus nutrition due to loss of vascularity with aging may aggravate the process of disc degeneration. So, angiogenesis may be useful in the healing process of degenerated disc. In this study, we wanted to evaluate the effect of atorvastatin, whose stimulating effect on angiogenesis on other tissues was shown in several studies, on degenerated intervertebral disc in rat.
Atorvastatin was administered intraperitoneally for 6 weeks in doses of 1, 4, and 8 mg/kg in rats after experimental disc degeneration. The rats intervertebral disc sections were stained immunohistochemically for von Willebrand Factor to evaluate the depth of vessels penetration and degree of vascularity.
In the nonoperated control group, the intervertebral discs were avascular. But experimental disc degeneration promoted angiogenesis. In this group, the mean of penetration was 49.25 μ (standard deviation = 19.905). Atorvastatin stimulated angiogenesis after experimental disc degeneration in the rats and the angiogenesis was more significant in the high and medium dose groups than operated control group. High-dose atorvastatin could not inhibit angiogenesis in experimental degenerated disc. There was no any significant difference in degree of vascularity among the groups.
Atorvastatin stimulates angiogenesis in experimental disc degeneration in rats. But, it does not show a biphasic effect. |
| doi_str_mv | 10.1097/BRS.0b013e3181d4e15a |
| format | Article |
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To evaluate the effects of atorvastatin on angiogenesis in experimental disc degeneration in rat.
Back pain is strongly associated with degenerated intervertebral disc and management of this condition is still empirical. Decrease of nucleus nutrition due to loss of vascularity with aging may aggravate the process of disc degeneration. So, angiogenesis may be useful in the healing process of degenerated disc. In this study, we wanted to evaluate the effect of atorvastatin, whose stimulating effect on angiogenesis on other tissues was shown in several studies, on degenerated intervertebral disc in rat.
Atorvastatin was administered intraperitoneally for 6 weeks in doses of 1, 4, and 8 mg/kg in rats after experimental disc degeneration. The rats intervertebral disc sections were stained immunohistochemically for von Willebrand Factor to evaluate the depth of vessels penetration and degree of vascularity.
In the nonoperated control group, the intervertebral discs were avascular. But experimental disc degeneration promoted angiogenesis. In this group, the mean of penetration was 49.25 μ (standard deviation = 19.905). Atorvastatin stimulated angiogenesis after experimental disc degeneration in the rats and the angiogenesis was more significant in the high and medium dose groups than operated control group. High-dose atorvastatin could not inhibit angiogenesis in experimental degenerated disc. There was no any significant difference in degree of vascularity among the groups.
Atorvastatin stimulates angiogenesis in experimental disc degeneration in rats. But, it does not show a biphasic effect.</description><identifier>ISSN: 0362-2436</identifier><identifier>EISSN: 1528-1159</identifier><identifier>DOI: 10.1097/BRS.0b013e3181d4e15a</identifier><identifier>PMID: 21057385</identifier><identifier>CODEN: SPINDD</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Angiogenesis Inducing Agents - pharmacology ; Animals ; Atorvastatin Calcium ; Biological and medical sciences ; Biomarkers - metabolism ; Cerebrospinal fluid. Meninges. Spinal cord ; Disease Models, Animal ; Heptanoic Acids - pharmacology ; Immunohistochemistry ; Injuries of the nervous system and the skull. Diseases due to physical agents ; Intervertebral Disc - blood supply ; Intervertebral Disc - drug effects ; Intervertebral Disc - metabolism ; Intervertebral Disc Degeneration - drug therapy ; Intervertebral Disc Degeneration - metabolism ; Intervertebral Disc Degeneration - physiopathology ; Male ; Medical sciences ; Neovascularization, Physiologic - drug effects ; Nervous system (semeiology, syndromes) ; Neurology ; Pyrroles - pharmacology ; Rats ; Rats, Wistar ; Time Factors ; Traumas. Diseases due to physical agents ; von Willebrand Factor - metabolism</subject><ispartof>Spine (Philadelphia, Pa. 1976), 2011-10, Vol.36 (22), p.1824-1828</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-fd53259704e0a6dc93d99469e87d9e9e68eb70484965229b378f0eb0add307533</citedby><cites>FETCH-LOGICAL-c365t-fd53259704e0a6dc93d99469e87d9e9e68eb70484965229b378f0eb0add307533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24735504$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21057385$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KARAMOUZIAN, Saeid</creatorcontrib><creatorcontrib>ESKANDARY, Hossein</creatorcontrib><creatorcontrib>SAEED, Alireza</creatorcontrib><creatorcontrib>REIHANI-KERMANI, Hamed</creatorcontrib><creatorcontrib>ABOOSAEEDI, Hamid Reza</creatorcontrib><creatorcontrib>MALEKPOOR-AFSHAR, Reza</creatorcontrib><creatorcontrib>SAFIZADE, Hossein</creatorcontrib><creatorcontrib>ESKANDARI, Mohammad</creatorcontrib><title>Effect of Atorvastatin on Angiogenesis in Degenerated Intervertebral Disc in Rat</title><title>Spine (Philadelphia, Pa. 1976)</title><addtitle>Spine (Phila Pa 1976)</addtitle><description>An experimental study to measure the depth of penetration of new vessels in degenerated intervertebral disc in rat.
To evaluate the effects of atorvastatin on angiogenesis in experimental disc degeneration in rat.
Back pain is strongly associated with degenerated intervertebral disc and management of this condition is still empirical. Decrease of nucleus nutrition due to loss of vascularity with aging may aggravate the process of disc degeneration. So, angiogenesis may be useful in the healing process of degenerated disc. In this study, we wanted to evaluate the effect of atorvastatin, whose stimulating effect on angiogenesis on other tissues was shown in several studies, on degenerated intervertebral disc in rat.
Atorvastatin was administered intraperitoneally for 6 weeks in doses of 1, 4, and 8 mg/kg in rats after experimental disc degeneration. The rats intervertebral disc sections were stained immunohistochemically for von Willebrand Factor to evaluate the depth of vessels penetration and degree of vascularity.
In the nonoperated control group, the intervertebral discs were avascular. But experimental disc degeneration promoted angiogenesis. In this group, the mean of penetration was 49.25 μ (standard deviation = 19.905). Atorvastatin stimulated angiogenesis after experimental disc degeneration in the rats and the angiogenesis was more significant in the high and medium dose groups than operated control group. High-dose atorvastatin could not inhibit angiogenesis in experimental degenerated disc. There was no any significant difference in degree of vascularity among the groups.
Atorvastatin stimulates angiogenesis in experimental disc degeneration in rats. But, it does not show a biphasic effect.</description><subject>Angiogenesis Inducing Agents - pharmacology</subject><subject>Animals</subject><subject>Atorvastatin Calcium</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - metabolism</subject><subject>Cerebrospinal fluid. Meninges. Spinal cord</subject><subject>Disease Models, Animal</subject><subject>Heptanoic Acids - pharmacology</subject><subject>Immunohistochemistry</subject><subject>Injuries of the nervous system and the skull. Diseases due to physical agents</subject><subject>Intervertebral Disc - blood supply</subject><subject>Intervertebral Disc - drug effects</subject><subject>Intervertebral Disc - metabolism</subject><subject>Intervertebral Disc Degeneration - drug therapy</subject><subject>Intervertebral Disc Degeneration - metabolism</subject><subject>Intervertebral Disc Degeneration - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neovascularization, Physiologic - drug effects</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Pyrroles - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Time Factors</subject><subject>Traumas. Diseases due to physical agents</subject><subject>von Willebrand Factor - metabolism</subject><issn>0362-2436</issn><issn>1528-1159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkFtLw0AQhRdRbK3-A5G8iE-ps9lLso_V1gsUlKrPYZOdLZE0qbvbgv_eLVYFn4aZ-c6c4RByTmFMQeXXN4uXMVRAGTJaUMORCn1AhlRkRUqpUIdkCExmacaZHJAT798BQDKqjskgoyByVogheZ5Zi3VIeptMQu-22gcdmi7pu2TSLZt-iR36xidxNMVd43RAkzx2Ad0WXcDK6TaZNr7eIQsdTsmR1a3Hs30dkbe72evtQzp_un-8nczTmkkRUmsEy4TKgSNoaWrFjFJcKixyo1ChLLCKy4IrKbJMVSwvLGAF2hgGuWBsRK6-765d_7FBH8pVfALbVnfYb3ypgFGeMw6R5N9k7XrvHdpy7ZqVdp8lhXIXZRmjLP9HGWUXe4NNtULzK_rJLgKXe0D7WrfW6a5u_B8X3YUAzr4ATPF8kQ</recordid><startdate>20111015</startdate><enddate>20111015</enddate><creator>KARAMOUZIAN, Saeid</creator><creator>ESKANDARY, Hossein</creator><creator>SAEED, Alireza</creator><creator>REIHANI-KERMANI, Hamed</creator><creator>ABOOSAEEDI, Hamid Reza</creator><creator>MALEKPOOR-AFSHAR, Reza</creator><creator>SAFIZADE, Hossein</creator><creator>ESKANDARI, Mohammad</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111015</creationdate><title>Effect of Atorvastatin on Angiogenesis in Degenerated Intervertebral Disc in Rat</title><author>KARAMOUZIAN, Saeid ; ESKANDARY, Hossein ; SAEED, Alireza ; REIHANI-KERMANI, Hamed ; ABOOSAEEDI, Hamid Reza ; MALEKPOOR-AFSHAR, Reza ; SAFIZADE, Hossein ; ESKANDARI, Mohammad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-fd53259704e0a6dc93d99469e87d9e9e68eb70484965229b378f0eb0add307533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Angiogenesis Inducing Agents - pharmacology</topic><topic>Animals</topic><topic>Atorvastatin Calcium</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - metabolism</topic><topic>Cerebrospinal fluid. Meninges. Spinal cord</topic><topic>Disease Models, Animal</topic><topic>Heptanoic Acids - pharmacology</topic><topic>Immunohistochemistry</topic><topic>Injuries of the nervous system and the skull. Diseases due to physical agents</topic><topic>Intervertebral Disc - blood supply</topic><topic>Intervertebral Disc - drug effects</topic><topic>Intervertebral Disc - metabolism</topic><topic>Intervertebral Disc Degeneration - drug therapy</topic><topic>Intervertebral Disc Degeneration - metabolism</topic><topic>Intervertebral Disc Degeneration - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neovascularization, Physiologic - drug effects</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Pyrroles - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Time Factors</topic><topic>Traumas. Diseases due to physical agents</topic><topic>von Willebrand Factor - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KARAMOUZIAN, Saeid</creatorcontrib><creatorcontrib>ESKANDARY, Hossein</creatorcontrib><creatorcontrib>SAEED, Alireza</creatorcontrib><creatorcontrib>REIHANI-KERMANI, Hamed</creatorcontrib><creatorcontrib>ABOOSAEEDI, Hamid Reza</creatorcontrib><creatorcontrib>MALEKPOOR-AFSHAR, Reza</creatorcontrib><creatorcontrib>SAFIZADE, Hossein</creatorcontrib><creatorcontrib>ESKANDARI, Mohammad</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Spine (Philadelphia, Pa. 1976)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KARAMOUZIAN, Saeid</au><au>ESKANDARY, Hossein</au><au>SAEED, Alireza</au><au>REIHANI-KERMANI, Hamed</au><au>ABOOSAEEDI, Hamid Reza</au><au>MALEKPOOR-AFSHAR, Reza</au><au>SAFIZADE, Hossein</au><au>ESKANDARI, Mohammad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Atorvastatin on Angiogenesis in Degenerated Intervertebral Disc in Rat</atitle><jtitle>Spine (Philadelphia, Pa. 1976)</jtitle><addtitle>Spine (Phila Pa 1976)</addtitle><date>2011-10-15</date><risdate>2011</risdate><volume>36</volume><issue>22</issue><spage>1824</spage><epage>1828</epage><pages>1824-1828</pages><issn>0362-2436</issn><eissn>1528-1159</eissn><coden>SPINDD</coden><abstract>An experimental study to measure the depth of penetration of new vessels in degenerated intervertebral disc in rat.
To evaluate the effects of atorvastatin on angiogenesis in experimental disc degeneration in rat.
Back pain is strongly associated with degenerated intervertebral disc and management of this condition is still empirical. Decrease of nucleus nutrition due to loss of vascularity with aging may aggravate the process of disc degeneration. So, angiogenesis may be useful in the healing process of degenerated disc. In this study, we wanted to evaluate the effect of atorvastatin, whose stimulating effect on angiogenesis on other tissues was shown in several studies, on degenerated intervertebral disc in rat.
Atorvastatin was administered intraperitoneally for 6 weeks in doses of 1, 4, and 8 mg/kg in rats after experimental disc degeneration. The rats intervertebral disc sections were stained immunohistochemically for von Willebrand Factor to evaluate the depth of vessels penetration and degree of vascularity.
In the nonoperated control group, the intervertebral discs were avascular. But experimental disc degeneration promoted angiogenesis. In this group, the mean of penetration was 49.25 μ (standard deviation = 19.905). Atorvastatin stimulated angiogenesis after experimental disc degeneration in the rats and the angiogenesis was more significant in the high and medium dose groups than operated control group. High-dose atorvastatin could not inhibit angiogenesis in experimental degenerated disc. There was no any significant difference in degree of vascularity among the groups.
Atorvastatin stimulates angiogenesis in experimental disc degeneration in rats. But, it does not show a biphasic effect.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>21057385</pmid><doi>10.1097/BRS.0b013e3181d4e15a</doi><tpages>5</tpages></addata></record> |
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| source | Journals@Ovid Ovid Autoload; MEDLINE |
| subjects | Angiogenesis Inducing Agents - pharmacology Animals Atorvastatin Calcium Biological and medical sciences Biomarkers - metabolism Cerebrospinal fluid. Meninges. Spinal cord Disease Models, Animal Heptanoic Acids - pharmacology Immunohistochemistry Injuries of the nervous system and the skull. Diseases due to physical agents Intervertebral Disc - blood supply Intervertebral Disc - drug effects Intervertebral Disc - metabolism Intervertebral Disc Degeneration - drug therapy Intervertebral Disc Degeneration - metabolism Intervertebral Disc Degeneration - physiopathology Male Medical sciences Neovascularization, Physiologic - drug effects Nervous system (semeiology, syndromes) Neurology Pyrroles - pharmacology Rats Rats, Wistar Time Factors Traumas. Diseases due to physical agents von Willebrand Factor - metabolism |
| title | Effect of Atorvastatin on Angiogenesis in Degenerated Intervertebral Disc in Rat |
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