Salivary chromogranin A, but not α-amylase, correlates with cardiovascular parameters during high-intensity exercise
Summary Introduction Several studies have shown that activation of the sympathetic nervous system results in the increased secretion of α‐amylase (sAA), an enzyme produced by salivary glands. Recently, chromogranin A (CgA), a soluble protein costored and coreleased with catecholamines from the adre...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2011-12, Vol.75 (6), p.747-752 |
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| creator | Gallina, Sabina Di Mauro, Michele D'Amico, Maria Angela D'Angelo, Emanuele Sablone, Andrea Di Fonso, Alessia Bascelli, Adriana Izzicupo, Pascal Di Baldassarre, Angela |
| description | Summary
Introduction Several studies have shown that activation of the sympathetic nervous system results in the increased secretion of α‐amylase (sAA), an enzyme produced by salivary glands. Recently, chromogranin A (CgA), a soluble protein costored and coreleased with catecholamines from the adrenal medulla and sympathetic nerve endings, has been proposed as a marker of sympathoadrenal medullary system (SAM) activity. The aim of this study was to investigate the behaviour of salivary chromogranin A (sCgA) and sAA during high‐intensity exercise and to analyse their possible correlation with cardiovascular and psychological parameters.
Methods Before and during a standardized treadmill stress test, and at 5, 15 and 30 min during the recovery phase, sCgA and sAA were monitored in 21 healthy men. The double product (DP) of blood pressure and heart rate responses, and the product of the subjective ratings of perceived exertion recorded at the final step (RPE) and the exercise duration were used as indices of cardiovascular and exercise intensity, respectively.
Results With respect to baseline, significant (P |
| doi_str_mv | 10.1111/j.1365-2265.2011.04143.x |
| format | Article |
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Introduction Several studies have shown that activation of the sympathetic nervous system results in the increased secretion of α‐amylase (sAA), an enzyme produced by salivary glands. Recently, chromogranin A (CgA), a soluble protein costored and coreleased with catecholamines from the adrenal medulla and sympathetic nerve endings, has been proposed as a marker of sympathoadrenal medullary system (SAM) activity. The aim of this study was to investigate the behaviour of salivary chromogranin A (sCgA) and sAA during high‐intensity exercise and to analyse their possible correlation with cardiovascular and psychological parameters.
Methods Before and during a standardized treadmill stress test, and at 5, 15 and 30 min during the recovery phase, sCgA and sAA were monitored in 21 healthy men. The double product (DP) of blood pressure and heart rate responses, and the product of the subjective ratings of perceived exertion recorded at the final step (RPE) and the exercise duration were used as indices of cardiovascular and exercise intensity, respectively.
Results With respect to baseline, significant (P < 0·001) increases in peak sCgA (median 64%) and sAA (median 86%) were observed at the end of exercise. During the recovery phase, sAA levels fell abruptly, whereas sCgA remained elevated (P < 0·001). Significant correlations emerged only for sCgA with respect to %DP (r = 0·84; P < 0·001) and last step‐RPE (r = 0·82; P = 0·024).
Conclusions These data suggest sCgA as a reliable marker of SAM activation. Furthermore, the relationship between sCgA and exercise intensity highlights the potential use of this noninvasive parameter in monitoring the adrenergic response during intense physical stress.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/j.1365-2265.2011.04143.x</identifier><identifier>PMID: 21671973</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; alpha-Amylases - analysis ; alpha-Amylases - metabolism ; Biological and medical sciences ; Cardiovascular Physiological Phenomena ; Cardiovascular System - metabolism ; Chromogranin A - analysis ; Chromogranin A - metabolism ; Endocrinopathies ; Exercise - physiology ; Exercise Test ; Fundamental and applied biological sciences. Psychology ; Humans ; Male ; Medical sciences ; Physical Exertion - physiology ; Saliva - chemistry ; Saliva - enzymology ; Saliva - metabolism ; Specimen Handling ; Vertebrates: endocrinology ; Young Adult</subject><ispartof>Clinical endocrinology (Oxford), 2011-12, Vol.75 (6), p.747-752</ispartof><rights>2011 Blackwell Publishing Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2011 Blackwell Publishing Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4203-ac25ad239ed0c1d9ec8e8521e2058e3aacab598760febe56393affe8ed0243a33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2265.2011.04143.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2265.2011.04143.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24735770$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21671973$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gallina, Sabina</creatorcontrib><creatorcontrib>Di Mauro, Michele</creatorcontrib><creatorcontrib>D'Amico, Maria Angela</creatorcontrib><creatorcontrib>D'Angelo, Emanuele</creatorcontrib><creatorcontrib>Sablone, Andrea</creatorcontrib><creatorcontrib>Di Fonso, Alessia</creatorcontrib><creatorcontrib>Bascelli, Adriana</creatorcontrib><creatorcontrib>Izzicupo, Pascal</creatorcontrib><creatorcontrib>Di Baldassarre, Angela</creatorcontrib><title>Salivary chromogranin A, but not α-amylase, correlates with cardiovascular parameters during high-intensity exercise</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description>Summary
Introduction Several studies have shown that activation of the sympathetic nervous system results in the increased secretion of α‐amylase (sAA), an enzyme produced by salivary glands. Recently, chromogranin A (CgA), a soluble protein costored and coreleased with catecholamines from the adrenal medulla and sympathetic nerve endings, has been proposed as a marker of sympathoadrenal medullary system (SAM) activity. The aim of this study was to investigate the behaviour of salivary chromogranin A (sCgA) and sAA during high‐intensity exercise and to analyse their possible correlation with cardiovascular and psychological parameters.
Methods Before and during a standardized treadmill stress test, and at 5, 15 and 30 min during the recovery phase, sCgA and sAA were monitored in 21 healthy men. The double product (DP) of blood pressure and heart rate responses, and the product of the subjective ratings of perceived exertion recorded at the final step (RPE) and the exercise duration were used as indices of cardiovascular and exercise intensity, respectively.
Results With respect to baseline, significant (P < 0·001) increases in peak sCgA (median 64%) and sAA (median 86%) were observed at the end of exercise. During the recovery phase, sAA levels fell abruptly, whereas sCgA remained elevated (P < 0·001). Significant correlations emerged only for sCgA with respect to %DP (r = 0·84; P < 0·001) and last step‐RPE (r = 0·82; P = 0·024).
Conclusions These data suggest sCgA as a reliable marker of SAM activation. Furthermore, the relationship between sCgA and exercise intensity highlights the potential use of this noninvasive parameter in monitoring the adrenergic response during intense physical stress.</description><subject>Adult</subject><subject>alpha-Amylases - analysis</subject><subject>alpha-Amylases - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular Physiological Phenomena</subject><subject>Cardiovascular System - metabolism</subject><subject>Chromogranin A - analysis</subject><subject>Chromogranin A - metabolism</subject><subject>Endocrinopathies</subject><subject>Exercise - physiology</subject><subject>Exercise Test</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Physical Exertion - physiology</subject><subject>Saliva - chemistry</subject><subject>Saliva - enzymology</subject><subject>Saliva - metabolism</subject><subject>Specimen Handling</subject><subject>Vertebrates: endocrinology</subject><subject>Young Adult</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcuO0zAUhi0EYsrAKyBvECwmwZc4ThYsRtUwoI4KaLgsrVPntHXJpdjJTPtYvAjPhENL2eGNLZ3vt3S-nxDKWcrjeb1JucxVIkSuUsE4T1nGM5nuHpDJafCQTJhkLGF5np2RJyFsGGOqYPoxORM817zUckKGW6jdHfg9tWvfNd3KQ-taenlBF0NP266nv34m0OxrCHhBbec91tBjoPeuX1MLvnLdHQQ71ODpFjw02KMPtBq8a1d07VbrxLU9tsH1e4o79NYFfEoeLaEO-Ox4n5Mvb68-T98lNx-u308vbxKbCSYTsEJBJWSJFbO8KtEWWCjBUcRFUAJYWKiy0Dlb4gJVLksJyyUWEReZBCnPycvDv1vf_Rgw9KZxwWJdQ4vdEEzJJM-UkjqSr_5L8iLqKoTQRUSfH9Fh0WBltt41UaD5KzUCL45AFAP1MiqNS__jMi2V1ixybw7cvatxf5pzZsaSzcaMXZqxSzOWbP6UbHZmejUfXzGfHPIu9Lg75cF_N7mWWplv82vz8dNs9nV2W5i5_A2X5KwQ</recordid><startdate>201112</startdate><enddate>201112</enddate><creator>Gallina, Sabina</creator><creator>Di Mauro, Michele</creator><creator>D'Amico, Maria Angela</creator><creator>D'Angelo, Emanuele</creator><creator>Sablone, Andrea</creator><creator>Di Fonso, Alessia</creator><creator>Bascelli, Adriana</creator><creator>Izzicupo, Pascal</creator><creator>Di Baldassarre, Angela</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201112</creationdate><title>Salivary chromogranin A, but not α-amylase, correlates with cardiovascular parameters during high-intensity exercise</title><author>Gallina, Sabina ; Di Mauro, Michele ; D'Amico, Maria Angela ; D'Angelo, Emanuele ; Sablone, Andrea ; Di Fonso, Alessia ; Bascelli, Adriana ; Izzicupo, Pascal ; Di Baldassarre, Angela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4203-ac25ad239ed0c1d9ec8e8521e2058e3aacab598760febe56393affe8ed0243a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>alpha-Amylases - analysis</topic><topic>alpha-Amylases - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular Physiological Phenomena</topic><topic>Cardiovascular System - metabolism</topic><topic>Chromogranin A - analysis</topic><topic>Chromogranin A - metabolism</topic><topic>Endocrinopathies</topic><topic>Exercise - physiology</topic><topic>Exercise Test</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Physical Exertion - physiology</topic><topic>Saliva - chemistry</topic><topic>Saliva - enzymology</topic><topic>Saliva - metabolism</topic><topic>Specimen Handling</topic><topic>Vertebrates: endocrinology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gallina, Sabina</creatorcontrib><creatorcontrib>Di Mauro, Michele</creatorcontrib><creatorcontrib>D'Amico, Maria Angela</creatorcontrib><creatorcontrib>D'Angelo, Emanuele</creatorcontrib><creatorcontrib>Sablone, Andrea</creatorcontrib><creatorcontrib>Di Fonso, Alessia</creatorcontrib><creatorcontrib>Bascelli, Adriana</creatorcontrib><creatorcontrib>Izzicupo, Pascal</creatorcontrib><creatorcontrib>Di Baldassarre, Angela</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gallina, Sabina</au><au>Di Mauro, Michele</au><au>D'Amico, Maria Angela</au><au>D'Angelo, Emanuele</au><au>Sablone, Andrea</au><au>Di Fonso, Alessia</au><au>Bascelli, Adriana</au><au>Izzicupo, Pascal</au><au>Di Baldassarre, Angela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Salivary chromogranin A, but not α-amylase, correlates with cardiovascular parameters during high-intensity exercise</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2011-12</date><risdate>2011</risdate><volume>75</volume><issue>6</issue><spage>747</spage><epage>752</epage><pages>747-752</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>Summary
Introduction Several studies have shown that activation of the sympathetic nervous system results in the increased secretion of α‐amylase (sAA), an enzyme produced by salivary glands. Recently, chromogranin A (CgA), a soluble protein costored and coreleased with catecholamines from the adrenal medulla and sympathetic nerve endings, has been proposed as a marker of sympathoadrenal medullary system (SAM) activity. The aim of this study was to investigate the behaviour of salivary chromogranin A (sCgA) and sAA during high‐intensity exercise and to analyse their possible correlation with cardiovascular and psychological parameters.
Methods Before and during a standardized treadmill stress test, and at 5, 15 and 30 min during the recovery phase, sCgA and sAA were monitored in 21 healthy men. The double product (DP) of blood pressure and heart rate responses, and the product of the subjective ratings of perceived exertion recorded at the final step (RPE) and the exercise duration were used as indices of cardiovascular and exercise intensity, respectively.
Results With respect to baseline, significant (P < 0·001) increases in peak sCgA (median 64%) and sAA (median 86%) were observed at the end of exercise. During the recovery phase, sAA levels fell abruptly, whereas sCgA remained elevated (P < 0·001). Significant correlations emerged only for sCgA with respect to %DP (r = 0·84; P < 0·001) and last step‐RPE (r = 0·82; P = 0·024).
Conclusions These data suggest sCgA as a reliable marker of SAM activation. Furthermore, the relationship between sCgA and exercise intensity highlights the potential use of this noninvasive parameter in monitoring the adrenergic response during intense physical stress.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21671973</pmid><doi>10.1111/j.1365-2265.2011.04143.x</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult alpha-Amylases - analysis alpha-Amylases - metabolism Biological and medical sciences Cardiovascular Physiological Phenomena Cardiovascular System - metabolism Chromogranin A - analysis Chromogranin A - metabolism Endocrinopathies Exercise - physiology Exercise Test Fundamental and applied biological sciences. Psychology Humans Male Medical sciences Physical Exertion - physiology Saliva - chemistry Saliva - enzymology Saliva - metabolism Specimen Handling Vertebrates: endocrinology Young Adult |
| title | Salivary chromogranin A, but not α-amylase, correlates with cardiovascular parameters during high-intensity exercise |
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