Arginine or citrulline associated with a statin stimulates nitric oxide production in bovine aortic endothelial cells

Nitric oxide (NO) is an antiatherogenic vasodilator synthesized from arginine and, indirectly, from citrulline through argininosuccinate synthase (ASS) and argininosuccinate lyase (ASL). Hypercholesterolemia-induced atherosclerosis is usually treated by statins, which decrease cholesterolemia and in...

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Veröffentlicht in:	European journal of pharmacology 2011-11, Vol.670 (2-3), p.566-570
Hauptverfasser:	Berthe, Marie-Clotilde, Bernard, Mélisande, Rasmusen, Carole, Darquy, Sylviane, Cynober, Luc, Couderc, Rémy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - cytology Arginine Arginine - pharmacology argininosuccinate lyase Argininosuccinate Lyase - genetics atherosclerosis Biological and medical sciences Cattle Caveolin 1 - genetics Citrulline Citrulline - pharmacology Drug Interactions Endothelial cell endothelial cells Endothelial Cells - drug effects Endothelial Cells - enzymology Endothelial Cells - metabolism endothelial nitric oxide synthase eNOS gene expression Gene Expression Regulation, Enzymologic - drug effects Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology inducible nitric oxide synthase Medical sciences messenger RNA Nitric oxide Nitric Oxide - biosynthesis Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type III - genetics pharmacology Pharmacology. Drug treatments protein synthesis proteins reverse transcriptase polymerase chain reaction Simvastatin - pharmacology
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