Correlation of fl/d3 polymorphism of growth hormone receptor with the first- and second-year response to recombinant human growth hormone therapy in pre-pubertal Greek children with idiopathic isolated growth hormone deficiency

Background: fl/d3 polymorphism in human GH receptor was correlated with the response to GH therapy in different groups of children with short stature. Aim: This is a 2-yr retrospective study which evaluates the influence of fl/d3 polymorphism to the 1 st -and 2 nd -year response to GH replacement th...

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Veröffentlicht in:	Journal of endocrinological investigation 2011-09, Vol.34 (8), p.609-614
Hauptverfasser:	Vassiliou, G., Rousso, I., Katzos, G., Vavatsi-Christaki, N., Tzimagiorgis, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Body Height - genetics Child Endocrinology Female Genotype Greece Growth Disorders - drug therapy Growth Disorders - genetics Human Growth Hormone - deficiency Human Growth Hormone - therapeutic use Humans Male Medicine Medicine & Public Health Metabolic Diseases Original Articles Polymorphism, Genetic Receptors, Somatotropin - genetics Receptors, Somatotropin - metabolism Recombinant Proteins - therapeutic use
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Zusammenfassung:	Background: fl/d3 polymorphism in human GH receptor was correlated with the response to GH therapy in different groups of children with short stature. Aim: This is a 2-yr retrospective study which evaluates the influence of fl/d3 polymorphism to the 1 st -and 2 nd -year response to GH replacement therapy in Greek children with isolated GH deficiency (GHD). Subjects and methods: A total number of 195 pre-pubertal Greek children were studied (121 controls and 74 patients with GH peak
ISSN:	0391-4097 1720-8386
DOI:	10.3275/7267