Simultaneous determination of naringin, hesperidin, neohesperidin, naringenin and hesperetin of Fractus aurantii extract in rat plasma by liquid chromatography tandem mass spectrometry
A liquid chromatography tandem mass spectrometry (LC–MS/MS) method was developed for the simultaneous determination of naringin, hesperidin, neohesperidin, naringenin and hesperetin in rat plasma, using liquiritin as the internal standard. Plasma samples extracted with a solid-phase extraction proce...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 2012-01, Vol.58 (25), p.58-64 |
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| container_title | Journal of pharmaceutical and biomedical analysis |
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| creator | Tong, Ling Zhou, Dandan Gao, Jun Zhu, Yonghong Sun, He Bi, Kaishun |
| description | A liquid chromatography tandem mass spectrometry (LC–MS/MS) method was developed for the simultaneous determination of naringin, hesperidin, neohesperidin, naringenin and hesperetin in rat plasma, using liquiritin as the internal standard. Plasma samples extracted with a solid-phase extraction procedure were separated on a Zorbax SB-C18 analytical column (2.1
mm
×
150
mm, 5
μm) and detected by electrospray ionization (ESI) in multiple reaction monitoring (MRM) mode. The calibration curves were linear over the range of 3.0–600
ng/ml for naringin, 0.5–100
ng/ml for hesperidin, 3.5–700
ng/ml for neohesperidin, 5.0–1000
ng/ml for naringenin and hesperetin, respectively. The lower limits of quantification were 0.5
ng/ml for naringin, hesperidin, naringenin and hesperetin, and 0.35
ng/ml for neohesperidin. Intra- and inter-day precision (RSD%) was less than 15% and accuracy (RE%) ranged from −3.3% to 4.8%. The validated method was successfully applied to investigate the pharmacokinetics of the major flavanones of
Fructus aurantii extract after oral administration to rats. |
| doi_str_mv | 10.1016/j.jpba.2011.05.001 |
| format | Article |
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mm
×
150
mm, 5
μm) and detected by electrospray ionization (ESI) in multiple reaction monitoring (MRM) mode. The calibration curves were linear over the range of 3.0–600
ng/ml for naringin, 0.5–100
ng/ml for hesperidin, 3.5–700
ng/ml for neohesperidin, 5.0–1000
ng/ml for naringenin and hesperetin, respectively. The lower limits of quantification were 0.5
ng/ml for naringin, hesperidin, naringenin and hesperetin, and 0.35
ng/ml for neohesperidin. Intra- and inter-day precision (RSD%) was less than 15% and accuracy (RE%) ranged from −3.3% to 4.8%. The validated method was successfully applied to investigate the pharmacokinetics of the major flavanones of
Fructus aurantii extract after oral administration to rats.</description><identifier>ISSN: 0731-7085</identifier><identifier>EISSN: 1873-264X</identifier><identifier>DOI: 10.1016/j.jpba.2011.05.001</identifier><identifier>PMID: 22018980</identifier><identifier>CODEN: JPBADA</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Analytical, structural and metabolic biochemistry ; Animals ; Biological and medical sciences ; Chromatography, Liquid - methods ; Determination ; Flavanones ; Flavanones - blood ; Fructus aurantii ; Fruit - chemistry ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; Glucosides - blood ; hesperetin ; hesperidin ; Hesperidin - blood ; ionization ; LC–MS/MS ; liquid chromatography ; Male ; Medical sciences ; monitoring ; naringenin ; naringin ; oral administration ; Pharmacokinetics ; Pharmacology. Drug treatments ; Rats ; Rats, Wistar ; Reference Standards ; solid phase extraction ; Solid Phase Extraction - methods ; Spectrometry, Mass, Electrospray Ionization - methods ; tandem mass spectrometry ; Tandem Mass Spectrometry - methods</subject><ispartof>Journal of pharmaceutical and biomedical analysis, 2012-01, Vol.58 (25), p.58-64</ispartof><rights>2011</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-2656dfc7bd19ea68d3050e5621c2ee44a620275381b934dbe8ed7a057643070d3</citedby><cites>FETCH-LOGICAL-c475t-2656dfc7bd19ea68d3050e5621c2ee44a620275381b934dbe8ed7a057643070d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpba.2011.05.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25233028$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22018980$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tong, Ling</creatorcontrib><creatorcontrib>Zhou, Dandan</creatorcontrib><creatorcontrib>Gao, Jun</creatorcontrib><creatorcontrib>Zhu, Yonghong</creatorcontrib><creatorcontrib>Sun, He</creatorcontrib><creatorcontrib>Bi, Kaishun</creatorcontrib><title>Simultaneous determination of naringin, hesperidin, neohesperidin, naringenin and hesperetin of Fractus aurantii extract in rat plasma by liquid chromatography tandem mass spectrometry</title><title>Journal of pharmaceutical and biomedical analysis</title><addtitle>J Pharm Biomed Anal</addtitle><description>A liquid chromatography tandem mass spectrometry (LC–MS/MS) method was developed for the simultaneous determination of naringin, hesperidin, neohesperidin, naringenin and hesperetin in rat plasma, using liquiritin as the internal standard. Plasma samples extracted with a solid-phase extraction procedure were separated on a Zorbax SB-C18 analytical column (2.1
mm
×
150
mm, 5
μm) and detected by electrospray ionization (ESI) in multiple reaction monitoring (MRM) mode. The calibration curves were linear over the range of 3.0–600
ng/ml for naringin, 0.5–100
ng/ml for hesperidin, 3.5–700
ng/ml for neohesperidin, 5.0–1000
ng/ml for naringenin and hesperetin, respectively. The lower limits of quantification were 0.5
ng/ml for naringin, hesperidin, naringenin and hesperetin, and 0.35
ng/ml for neohesperidin. Intra- and inter-day precision (RSD%) was less than 15% and accuracy (RE%) ranged from −3.3% to 4.8%. The validated method was successfully applied to investigate the pharmacokinetics of the major flavanones of
Fructus aurantii extract after oral administration to rats.</description><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chromatography, Liquid - methods</subject><subject>Determination</subject><subject>Flavanones</subject><subject>Flavanones - blood</subject><subject>Fructus aurantii</subject><subject>Fruit - chemistry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Glucosides - blood</subject><subject>hesperetin</subject><subject>hesperidin</subject><subject>Hesperidin - blood</subject><subject>ionization</subject><subject>LC–MS/MS</subject><subject>liquid chromatography</subject><subject>Male</subject><subject>Medical sciences</subject><subject>monitoring</subject><subject>naringenin</subject><subject>naringin</subject><subject>oral administration</subject><subject>Pharmacokinetics</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reference Standards</subject><subject>solid phase extraction</subject><subject>Solid Phase Extraction - methods</subject><subject>Spectrometry, Mass, Electrospray Ionization - methods</subject><subject>tandem mass spectrometry</subject><subject>Tandem Mass Spectrometry - methods</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9u1DAQxiMEokvhBTiAL4gLG8ZOnGQlLqiiFKkSh1KJmzWxJ7teJU5qO4h9Mx4Pp7sUceHkP_Obb0bfl2UvOeQcePV-n--nFnMBnOcgcwD-KFvxpi7Woiq_P85WUBd8XUMjz7JnIewBQPJN-TQ7E6mn2TSwyn7d2GHuIzoa58AMRfKDdRjt6NjYMYfeuq1179iOwkTemuWe4H-e9xA56xg6cyIp2nuFS486JmmcPbpoLaOfcfliqewxsqnHMCBrD6y3d7M1TO_8OGActx6n3YGl1QwNbMAQWNLVMVUp-sPz7EmHfaAXp_M8u7389O3ian399fOXi4_Xa13WMiYnZGU6XbeGbwirxhQggWQluBZEZYmVAFHLouHtpihNSw2ZGkHWVVlADaY4z94edSc_3s0Uohps0NT3R8vUBkRVlyCbRIojqf0YgqdOTd4O6A-Kg1oCU3u1BKaWwBRIlQJLTa9O8nM7kHlo-ZNQAt6cAAwa-y65qG34y0lRFCCW6a-PXIejwq1PzO1NEpFpioCmKBPx4UhQsuuHJa-CtuQ0GeuTr8qM9n-b_gYUOsIh</recordid><startdate>20120125</startdate><enddate>20120125</enddate><creator>Tong, Ling</creator><creator>Zhou, Dandan</creator><creator>Gao, Jun</creator><creator>Zhu, Yonghong</creator><creator>Sun, He</creator><creator>Bi, Kaishun</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120125</creationdate><title>Simultaneous determination of naringin, hesperidin, neohesperidin, naringenin and hesperetin of Fractus aurantii extract in rat plasma by liquid chromatography tandem mass spectrometry</title><author>Tong, Ling ; Zhou, Dandan ; Gao, Jun ; Zhu, Yonghong ; Sun, He ; Bi, Kaishun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-2656dfc7bd19ea68d3050e5621c2ee44a620275381b934dbe8ed7a057643070d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chromatography, Liquid - methods</topic><topic>Determination</topic><topic>Flavanones</topic><topic>Flavanones - blood</topic><topic>Fructus aurantii</topic><topic>Fruit - chemistry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>Glucosides - blood</topic><topic>hesperetin</topic><topic>hesperidin</topic><topic>Hesperidin - blood</topic><topic>ionization</topic><topic>LC–MS/MS</topic><topic>liquid chromatography</topic><topic>Male</topic><topic>Medical sciences</topic><topic>monitoring</topic><topic>naringenin</topic><topic>naringin</topic><topic>oral administration</topic><topic>Pharmacokinetics</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reference Standards</topic><topic>solid phase extraction</topic><topic>Solid Phase Extraction - methods</topic><topic>Spectrometry, Mass, Electrospray Ionization - methods</topic><topic>tandem mass spectrometry</topic><topic>Tandem Mass Spectrometry - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tong, Ling</creatorcontrib><creatorcontrib>Zhou, Dandan</creatorcontrib><creatorcontrib>Gao, Jun</creatorcontrib><creatorcontrib>Zhu, Yonghong</creatorcontrib><creatorcontrib>Sun, He</creatorcontrib><creatorcontrib>Bi, Kaishun</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tong, Ling</au><au>Zhou, Dandan</au><au>Gao, Jun</au><au>Zhu, Yonghong</au><au>Sun, He</au><au>Bi, Kaishun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simultaneous determination of naringin, hesperidin, neohesperidin, naringenin and hesperetin of Fractus aurantii extract in rat plasma by liquid chromatography tandem mass spectrometry</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>2012-01-25</date><risdate>2012</risdate><volume>58</volume><issue>25</issue><spage>58</spage><epage>64</epage><pages>58-64</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>A liquid chromatography tandem mass spectrometry (LC–MS/MS) method was developed for the simultaneous determination of naringin, hesperidin, neohesperidin, naringenin and hesperetin in rat plasma, using liquiritin as the internal standard. Plasma samples extracted with a solid-phase extraction procedure were separated on a Zorbax SB-C18 analytical column (2.1
mm
×
150
mm, 5
μm) and detected by electrospray ionization (ESI) in multiple reaction monitoring (MRM) mode. The calibration curves were linear over the range of 3.0–600
ng/ml for naringin, 0.5–100
ng/ml for hesperidin, 3.5–700
ng/ml for neohesperidin, 5.0–1000
ng/ml for naringenin and hesperetin, respectively. The lower limits of quantification were 0.5
ng/ml for naringin, hesperidin, naringenin and hesperetin, and 0.35
ng/ml for neohesperidin. Intra- and inter-day precision (RSD%) was less than 15% and accuracy (RE%) ranged from −3.3% to 4.8%. The validated method was successfully applied to investigate the pharmacokinetics of the major flavanones of
Fructus aurantii extract after oral administration to rats.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>22018980</pmid><doi>10.1016/j.jpba.2011.05.001</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0731-7085 |
| ispartof | Journal of pharmaceutical and biomedical analysis, 2012-01, Vol.58 (25), p.58-64 |
| issn | 0731-7085 1873-264X |
| language | eng |
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| subjects | Analysis Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Chromatography, Liquid - methods Determination Flavanones Flavanones - blood Fructus aurantii Fruit - chemistry Fundamental and applied biological sciences. Psychology General pharmacology Glucosides - blood hesperetin hesperidin Hesperidin - blood ionization LC–MS/MS liquid chromatography Male Medical sciences monitoring naringenin naringin oral administration Pharmacokinetics Pharmacology. Drug treatments Rats Rats, Wistar Reference Standards solid phase extraction Solid Phase Extraction - methods Spectrometry, Mass, Electrospray Ionization - methods tandem mass spectrometry Tandem Mass Spectrometry - methods |
| title | Simultaneous determination of naringin, hesperidin, neohesperidin, naringenin and hesperetin of Fractus aurantii extract in rat plasma by liquid chromatography tandem mass spectrometry |
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