Metabolic correlates of tumour hypoxia in malignant canine mammary carcinoma
Given its importance in human and canine tumour biology, a profound understanding of tumour hypoxia is of paramount importance. Therefore, the aim of this work was to investigate the relationship between tumour hypoxia and the expression of a number of hypoxia-induced proteins that play a role in tu...
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| Veröffentlicht in: | Research in veterinary science 2011-12, Vol.91 (3), p.e125-e128 |
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| container_title | Research in veterinary science |
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| creator | Mees, G. Vangestel, C. Dierckx, R. Loomans, S. Van Damme, N. Peremans, K. De Rooster, H. Van Goethem, B. Pauwels, P. Ducatelle, R. Van de Wiele, C. |
| description | Given its importance in human and canine tumour biology, a profound understanding of tumour hypoxia is of paramount importance. Therefore, the aim of this work was to investigate the relationship between tumour hypoxia and the expression of a number of hypoxia-induced proteins that play a role in tumour metabolism. The hypoxia marker pimonidazole was administered to dogs affected by spontaneous mammary carcinoma and compared with immunohistochemical staining for GLUT1 and 3, HK 2 and CA IX. A statistically significant correlation was found between pimonidazole staining and GLUT1-expression (
R
=
0.607;
p
=
0.001). These results indicate a strong interaction between tumour hypoxia and tumour metabolism by the induction of proteins essential to maintain a stable tumour microenvironment. |
| doi_str_mv | 10.1016/j.rvsc.2011.01.014 |
| format | Article |
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R
=
0.607;
p
=
0.001). These results indicate a strong interaction between tumour hypoxia and tumour metabolism by the induction of proteins essential to maintain a stable tumour microenvironment.</description><identifier>ISSN: 0034-5288</identifier><identifier>EISSN: 1532-2661</identifier><identifier>DOI: 10.1016/j.rvsc.2011.01.014</identifier><identifier>PMID: 21316722</identifier><language>eng</language><publisher>England: Elsevier India Pvt Ltd</publisher><subject>Animals ; Cancer ; carcinoma ; Dog Diseases - metabolism ; Dog Diseases - surgery ; Dogs ; Female ; Gene Expression Regulation, Neoplastic - physiology ; Glucose ; Glucose Transporter Type 1 - genetics ; Glucose Transporter Type 1 - metabolism ; GLUT ; humans ; Hypoxia ; Immunohistochemistry ; Mammary Neoplasms, Animal - metabolism ; Mammary Neoplasms, Animal - surgery ; Nitroimidazoles ; Oxygen Consumption ; Pimonidazole ; protein metabolism ; proteins ; Radiation-Sensitizing Agents ; Staining and Labeling ; Studies ; Tumour hypoxia ; Veterinary medicine</subject><ispartof>Research in veterinary science, 2011-12, Vol.91 (3), p.e125-e128</ispartof><rights>2011 Elsevier Ltd</rights><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-d5cd8328d1a417ff95274b503c65954917cd68f96349da75c8cbd9c58d21686f3</citedby><cites>FETCH-LOGICAL-c440t-d5cd8328d1a417ff95274b503c65954917cd68f96349da75c8cbd9c58d21686f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.rvsc.2011.01.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21316722$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mees, G.</creatorcontrib><creatorcontrib>Vangestel, C.</creatorcontrib><creatorcontrib>Dierckx, R.</creatorcontrib><creatorcontrib>Loomans, S.</creatorcontrib><creatorcontrib>Van Damme, N.</creatorcontrib><creatorcontrib>Peremans, K.</creatorcontrib><creatorcontrib>De Rooster, H.</creatorcontrib><creatorcontrib>Van Goethem, B.</creatorcontrib><creatorcontrib>Pauwels, P.</creatorcontrib><creatorcontrib>Ducatelle, R.</creatorcontrib><creatorcontrib>Van de Wiele, C.</creatorcontrib><title>Metabolic correlates of tumour hypoxia in malignant canine mammary carcinoma</title><title>Research in veterinary science</title><addtitle>Res Vet Sci</addtitle><description>Given its importance in human and canine tumour biology, a profound understanding of tumour hypoxia is of paramount importance. Therefore, the aim of this work was to investigate the relationship between tumour hypoxia and the expression of a number of hypoxia-induced proteins that play a role in tumour metabolism. The hypoxia marker pimonidazole was administered to dogs affected by spontaneous mammary carcinoma and compared with immunohistochemical staining for GLUT1 and 3, HK 2 and CA IX. A statistically significant correlation was found between pimonidazole staining and GLUT1-expression (
R
=
0.607;
p
=
0.001). These results indicate a strong interaction between tumour hypoxia and tumour metabolism by the induction of proteins essential to maintain a stable tumour microenvironment.</description><subject>Animals</subject><subject>Cancer</subject><subject>carcinoma</subject><subject>Dog Diseases - metabolism</subject><subject>Dog Diseases - surgery</subject><subject>Dogs</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic - physiology</subject><subject>Glucose</subject><subject>Glucose Transporter Type 1 - genetics</subject><subject>Glucose Transporter Type 1 - metabolism</subject><subject>GLUT</subject><subject>humans</subject><subject>Hypoxia</subject><subject>Immunohistochemistry</subject><subject>Mammary Neoplasms, Animal - metabolism</subject><subject>Mammary Neoplasms, Animal - surgery</subject><subject>Nitroimidazoles</subject><subject>Oxygen Consumption</subject><subject>Pimonidazole</subject><subject>protein metabolism</subject><subject>proteins</subject><subject>Radiation-Sensitizing Agents</subject><subject>Staining and Labeling</subject><subject>Studies</subject><subject>Tumour hypoxia</subject><subject>Veterinary medicine</subject><issn>0034-5288</issn><issn>1532-2661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9r3DAQxUVpaTZpv0AOraGH5OKtRv8sQS4hJGlhSw9tzkIryakWW9pKdmi-fWU26aGHwMAw4jeP0XsInQJeAwbxebfOD8WuCQZY46XYK7QCTklLhIDXaIUxZS0nUh6h41J2GGMG0L1FRwQoiI6QFdp885PZpiHYxqac_WAmX5rUN9M8pjk3vx736U8wTYjNaIZwH02cGmtiiL4-jKPJj3XMNsQ0mnfoTW-G4t8_9RN0d3P98-pLu_l--_XqctNaxvDUOm6dpEQ6MAy6vlecdGzLMbWCK84UdNYJ2StBmXKm41barVOWS0dASNHTE3R20N3n9Hv2ZdJjKNYPg4k-zUUrTERHlYRKnr9IVr1OiGoRrein_9BdNSDWf2jAlGOGOVeVIgfK5lRK9r3e57C4UCG9pKJ3eklFL6lovBSrSx-epOft6N2_lecYKvDxAPQmaXOfQ9F3P6oCw1VRCCYqcXEgfPX1Ifisiw0-Wu9C9nbSLoWXLvgLkpSlmA</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>Mees, G.</creator><creator>Vangestel, C.</creator><creator>Dierckx, R.</creator><creator>Loomans, S.</creator><creator>Van Damme, N.</creator><creator>Peremans, K.</creator><creator>De Rooster, H.</creator><creator>Van Goethem, B.</creator><creator>Pauwels, P.</creator><creator>Ducatelle, R.</creator><creator>Van de Wiele, C.</creator><general>Elsevier India Pvt Ltd</general><general>Elsevier Limited</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20111201</creationdate><title>Metabolic correlates of tumour hypoxia in malignant canine mammary carcinoma</title><author>Mees, G. ; 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Therefore, the aim of this work was to investigate the relationship between tumour hypoxia and the expression of a number of hypoxia-induced proteins that play a role in tumour metabolism. The hypoxia marker pimonidazole was administered to dogs affected by spontaneous mammary carcinoma and compared with immunohistochemical staining for GLUT1 and 3, HK 2 and CA IX. A statistically significant correlation was found between pimonidazole staining and GLUT1-expression (
R
=
0.607;
p
=
0.001). These results indicate a strong interaction between tumour hypoxia and tumour metabolism by the induction of proteins essential to maintain a stable tumour microenvironment.</abstract><cop>England</cop><pub>Elsevier India Pvt Ltd</pub><pmid>21316722</pmid><doi>10.1016/j.rvsc.2011.01.014</doi></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Cancer carcinoma Dog Diseases - metabolism Dog Diseases - surgery Dogs Female Gene Expression Regulation, Neoplastic - physiology Glucose Glucose Transporter Type 1 - genetics Glucose Transporter Type 1 - metabolism GLUT humans Hypoxia Immunohistochemistry Mammary Neoplasms, Animal - metabolism Mammary Neoplasms, Animal - surgery Nitroimidazoles Oxygen Consumption Pimonidazole protein metabolism proteins Radiation-Sensitizing Agents Staining and Labeling Studies Tumour hypoxia Veterinary medicine |
| title | Metabolic correlates of tumour hypoxia in malignant canine mammary carcinoma |
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