Determination of volatile organic compounds as biomarkers of lung cancer by SPME–GC–TOF/MS and chemometrics

A method for qualitative and quantitative the determination of concentrations volatile organic compounds (VOCs) in human breath samples using solid phase microextraction (SPME) and gas chromatography–time of flight–mass spectrometry (GC–TOF/MS) has been carried out. They are employed for the preconc...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2011-11, Vol.879 (30), p.3360-3366
Hauptverfasser:	Rudnicka, Joanna, Kowalkowski, Tomasz, Ligor, Tomasz, Buszewski, Bogusław
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Biomarkers, Tumor - analysis Biomarkers, Tumor - metabolism Breath Tests - methods Case-Control Studies Female Fundamental and applied biological sciences. Psychology Gas Chromatography-Mass Spectrometry - methods Gas chromatography–time of flight–mass spectrometry General pharmacology Humans Linear Models Lung cancer Lung Neoplasms - chemistry Lung Neoplasms - metabolism Male Medical sciences Middle Aged Pharmacology. Drug treatments Principal Component Analysis Reproducibility of Results Sensitivity and Specificity Solid phase microextraction Solid Phase Microextraction - methods Statistics Statistics, Nonparametric Volatile organic compounds Volatile Organic Compounds - analysis Volatile Organic Compounds - metabolism
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