Auditory working memory in HIV-1 infection
We evaluated auditory working memory in 41 HIV-seropositive (HIV+) and 37 HIV-seronegative (HIV−) male drug users, employing a modified version of the Letter-Number Span Task developed by Gold and colleagues. We added a control condition to the standard task in order to evaluate more directly the co...
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| Veröffentlicht in: | Journal of the International Neuropsychological Society 2001-01, Vol.7 (1), p.20-26 |
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| container_title | Journal of the International Neuropsychological Society |
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| creator | MARTIN, EILEEN M. SULLIVAN, T. SHAWN REED, ROBYN A. FLETCHER, TONY A. PITRAK, DAVID L. WEDDINGTON, WILLIAM HARROW, MARTIN |
| description | We evaluated auditory working memory in 41 HIV-seropositive
(HIV+) and 37 HIV-seronegative (HIV−) male drug users,
employing a modified version of the Letter-Number Span
Task developed by Gold and colleagues. We added a control
condition to the standard task in order to evaluate more
directly the contribution of the processing component to
the working memory deficits with the effects of storage
demands minimized. HIV+ subjects performed significantly
more poorly compared to controls on an index of working
memory processing derived from raw scores obtained under
the two testing conditions. These findings are consistent
with our previous reports that HIV-related working memory
deficits are evident across multiple informational domains;
further, the deficit appears to involve multiple-component
functions of working memory. Converging findings from recent
working memory studies and from primate and neuroimaging
investigations suggest that functional abnormalities of
prefrontal cortex should receive greater emphasis in models
of neurocognitive aspects of HIV-1 infection, which have
typically emphasized “subcortical” deficits.
(JINS, 2001, 7, 20–26.) |
| doi_str_mv | 10.1017/S1355617701711022 |
| format | Article |
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(HIV+) and 37 HIV-seronegative (HIV−) male drug users,
employing a modified version of the Letter-Number Span
Task developed by Gold and colleagues. We added a control
condition to the standard task in order to evaluate more
directly the contribution of the processing component to
the working memory deficits with the effects of storage
demands minimized. HIV+ subjects performed significantly
more poorly compared to controls on an index of working
memory processing derived from raw scores obtained under
the two testing conditions. These findings are consistent
with our previous reports that HIV-related working memory
deficits are evident across multiple informational domains;
further, the deficit appears to involve multiple-component
functions of working memory. Converging findings from recent
working memory studies and from primate and neuroimaging
investigations suggest that functional abnormalities of
prefrontal cortex should receive greater emphasis in models
of neurocognitive aspects of HIV-1 infection, which have
typically emphasized “subcortical” deficits.
(JINS, 2001, 7, 20–26.)</description><identifier>ISSN: 1355-6177</identifier><identifier>EISSN: 1469-7661</identifier><identifier>DOI: 10.1017/S1355617701711022</identifier><identifier>PMID: 11253838</identifier><language>eng</language><publisher>England: Cambridge University Press</publisher><subject>Acquired immune deficiency syndrome ; AIDS ; AIDS Dementia Complex - complications ; AIDS Dementia Complex - physiopathology ; AIDS Dementia Complex - psychology ; Auditory Perception - physiology ; Dementia ; Depression - etiology ; Drug abuse ; Drug therapy ; HIV ; HIV Seropositivity - complications ; HIV-1 ; Human immunodeficiency virus ; Human immunodeficiency virus 1 ; Humans ; Infections ; Infectious diseases ; Male ; Memory ; Memory Disorders - diagnosis ; Memory Disorders - etiology ; Middle Aged ; Neuropsychological Tests ; Neuropsychology ; Prefrontal cortex ; Prefrontal Cortex - physiopathology ; Primates ; Substance-Related Disorders - complications ; Working memory</subject><ispartof>Journal of the International Neuropsychological Society, 2001-01, Vol.7 (1), p.20-26</ispartof><rights>2001 The International Neuropsychological Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-88695b5bbfab60a666710eddc2bad9b2847a83cf408248de02eabb9bcab2a97c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S1355617701711022/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27901,27902,55603</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11253838$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MARTIN, EILEEN M.</creatorcontrib><creatorcontrib>SULLIVAN, T. SHAWN</creatorcontrib><creatorcontrib>REED, ROBYN A.</creatorcontrib><creatorcontrib>FLETCHER, TONY A.</creatorcontrib><creatorcontrib>PITRAK, DAVID L.</creatorcontrib><creatorcontrib>WEDDINGTON, WILLIAM</creatorcontrib><creatorcontrib>HARROW, MARTIN</creatorcontrib><title>Auditory working memory in HIV-1 infection</title><title>Journal of the International Neuropsychological Society</title><addtitle>J Int Neuropsychol Soc</addtitle><description>We evaluated auditory working memory in 41 HIV-seropositive
(HIV+) and 37 HIV-seronegative (HIV−) male drug users,
employing a modified version of the Letter-Number Span
Task developed by Gold and colleagues. We added a control
condition to the standard task in order to evaluate more
directly the contribution of the processing component to
the working memory deficits with the effects of storage
demands minimized. HIV+ subjects performed significantly
more poorly compared to controls on an index of working
memory processing derived from raw scores obtained under
the two testing conditions. These findings are consistent
with our previous reports that HIV-related working memory
deficits are evident across multiple informational domains;
further, the deficit appears to involve multiple-component
functions of working memory. Converging findings from recent
working memory studies and from primate and neuroimaging
investigations suggest that functional abnormalities of
prefrontal cortex should receive greater emphasis in models
of neurocognitive aspects of HIV-1 infection, which have
typically emphasized “subcortical” deficits.
(JINS, 2001, 7, 20–26.)</description><subject>Acquired immune deficiency syndrome</subject><subject>AIDS</subject><subject>AIDS Dementia Complex - complications</subject><subject>AIDS Dementia Complex - physiopathology</subject><subject>AIDS Dementia Complex - psychology</subject><subject>Auditory Perception - physiology</subject><subject>Dementia</subject><subject>Depression - etiology</subject><subject>Drug abuse</subject><subject>Drug therapy</subject><subject>HIV</subject><subject>HIV Seropositivity - complications</subject><subject>HIV-1</subject><subject>Human immunodeficiency virus</subject><subject>Human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Memory</subject><subject>Memory Disorders - diagnosis</subject><subject>Memory Disorders - etiology</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><subject>Neuropsychology</subject><subject>Prefrontal cortex</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Primates</subject><subject>Substance-Related Disorders - complications</subject><subject>Working memory</subject><issn>1355-6177</issn><issn>1469-7661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kN1LwzAUxYMozq8_wBcZvghCNTdpPvoow33AUIY6wZeQtOnotraatOj-ezM2HCg-3Xs5v3s4HITOAd8ABnH7BJQxDkKEAwATsoeOIOZJJDiH_bAHOVrrHXTs_RxjoIDxIeoAEEYllUfo-q7NiqZ2q-5n7RZFNeuWtlyfRdUdjqYRhCW3aVPU1Sk6yPXS27PtPEEv_fvn3jAaPw5GvbtxlMZYNJGUPGGGGZNrw7HmnAvANstSYnSWGCJjoSVN8xhLEsvMYmK1MYlJtSE6ESk9QVcb33dXf7TWN6osfGqXS13ZuvUqwYRKQmII5OUvcl63rgrhFAEpE8YYDRBsoNTV3jubq3dXlNqtFGC1rlH9qTH8XGyNW1PabPex7S0A0QYofGO_fnTtFooLKpjig4mSk4fX_vStp9aGdBtCl8YV2czuov4f4xt3RIlz</recordid><startdate>200101</startdate><enddate>200101</enddate><creator>MARTIN, EILEEN M.</creator><creator>SULLIVAN, T. SHAWN</creator><creator>REED, ROBYN A.</creator><creator>FLETCHER, TONY A.</creator><creator>PITRAK, DAVID L.</creator><creator>WEDDINGTON, WILLIAM</creator><creator>HARROW, MARTIN</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>200101</creationdate><title>Auditory working memory in HIV-1 infection</title><author>MARTIN, EILEEN M. ; SULLIVAN, T. SHAWN ; REED, ROBYN A. ; FLETCHER, TONY A. ; PITRAK, DAVID L. ; WEDDINGTON, WILLIAM ; HARROW, MARTIN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-88695b5bbfab60a666710eddc2bad9b2847a83cf408248de02eabb9bcab2a97c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>AIDS</topic><topic>AIDS Dementia Complex - complications</topic><topic>AIDS Dementia Complex - physiopathology</topic><topic>AIDS Dementia Complex - psychology</topic><topic>Auditory Perception - physiology</topic><topic>Dementia</topic><topic>Depression - etiology</topic><topic>Drug abuse</topic><topic>Drug therapy</topic><topic>HIV</topic><topic>HIV Seropositivity - complications</topic><topic>HIV-1</topic><topic>Human immunodeficiency virus</topic><topic>Human immunodeficiency virus 1</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Memory</topic><topic>Memory Disorders - diagnosis</topic><topic>Memory Disorders - etiology</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests</topic><topic>Neuropsychology</topic><topic>Prefrontal cortex</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>Primates</topic><topic>Substance-Related Disorders - complications</topic><topic>Working memory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MARTIN, EILEEN M.</creatorcontrib><creatorcontrib>SULLIVAN, T. SHAWN</creatorcontrib><creatorcontrib>REED, ROBYN A.</creatorcontrib><creatorcontrib>FLETCHER, TONY A.</creatorcontrib><creatorcontrib>PITRAK, DAVID L.</creatorcontrib><creatorcontrib>WEDDINGTON, WILLIAM</creatorcontrib><creatorcontrib>HARROW, MARTIN</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Journal of the International Neuropsychological Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MARTIN, EILEEN M.</au><au>SULLIVAN, T. SHAWN</au><au>REED, ROBYN A.</au><au>FLETCHER, TONY A.</au><au>PITRAK, DAVID L.</au><au>WEDDINGTON, WILLIAM</au><au>HARROW, MARTIN</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Auditory working memory in HIV-1 infection</atitle><jtitle>Journal of the International Neuropsychological Society</jtitle><addtitle>J Int Neuropsychol Soc</addtitle><date>2001-01</date><risdate>2001</risdate><volume>7</volume><issue>1</issue><spage>20</spage><epage>26</epage><pages>20-26</pages><issn>1355-6177</issn><eissn>1469-7661</eissn><abstract>We evaluated auditory working memory in 41 HIV-seropositive
(HIV+) and 37 HIV-seronegative (HIV−) male drug users,
employing a modified version of the Letter-Number Span
Task developed by Gold and colleagues. We added a control
condition to the standard task in order to evaluate more
directly the contribution of the processing component to
the working memory deficits with the effects of storage
demands minimized. HIV+ subjects performed significantly
more poorly compared to controls on an index of working
memory processing derived from raw scores obtained under
the two testing conditions. These findings are consistent
with our previous reports that HIV-related working memory
deficits are evident across multiple informational domains;
further, the deficit appears to involve multiple-component
functions of working memory. Converging findings from recent
working memory studies and from primate and neuroimaging
investigations suggest that functional abnormalities of
prefrontal cortex should receive greater emphasis in models
of neurocognitive aspects of HIV-1 infection, which have
typically emphasized “subcortical” deficits.
(JINS, 2001, 7, 20–26.)</abstract><cop>England</cop><pub>Cambridge University Press</pub><pmid>11253838</pmid><doi>10.1017/S1355617701711022</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1355-6177 |
| ispartof | Journal of the International Neuropsychological Society, 2001-01, Vol.7 (1), p.20-26 |
| issn | 1355-6177 1469-7661 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_902382241 |
| source | MEDLINE; Cambridge University Press Journals Complete |
| subjects | Acquired immune deficiency syndrome AIDS AIDS Dementia Complex - complications AIDS Dementia Complex - physiopathology AIDS Dementia Complex - psychology Auditory Perception - physiology Dementia Depression - etiology Drug abuse Drug therapy HIV HIV Seropositivity - complications HIV-1 Human immunodeficiency virus Human immunodeficiency virus 1 Humans Infections Infectious diseases Male Memory Memory Disorders - diagnosis Memory Disorders - etiology Middle Aged Neuropsychological Tests Neuropsychology Prefrontal cortex Prefrontal Cortex - physiopathology Primates Substance-Related Disorders - complications Working memory |
| title | Auditory working memory in HIV-1 infection |
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