A Hyperlipidemic Rabbit Model Provides New Insights into Pulmonary Zinc Exposure Effects on Cardiovascular Health

This study ascertains the effects of zinc, a major component of particulate matter, on pulmonary and systemic endpoints using hyperlipidemic rabbits to model diet-induced human atherosclerosis. New Zealand White rabbits were fed a normal or cholesterol-enriched diet and then were intratracheally ins...

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Veröffentlicht in:	Cardiovascular toxicology 2008-12, Vol.8 (4), p.195-206
Hauptverfasser:	LaGier, Adriana J., Manzo, Nick D., Carll, Alex P., Jaskot, Richard H., Slade, Ralph, Richards, Judy H., Winsett, Darrell W., Farraj, Aimen K., Dye, Janice A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylglucosaminidase - analysis Animals Atherosclerosis - chemically induced Atherosclerosis - metabolism Biomedical and Life Sciences Biomedicine Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology Cardiology Cholesterol Cholesterol - blood Disease Models, Animal Dose-Response Relationship, Drug Glutathione Disulfide - analysis Heart Rate - drug effects Heart Rate - physiology Hyperlipidemias - chemically induced Hyperlipidemias - metabolism Inhalation Exposure Intubation, Intratracheal Leukocyte Count Lung - drug effects Lung - metabolism Male Nitrites - blood Particulate Matter - toxicity Pharmacology/Toxicology Rabbits Zinc Zinc Oxide - toxicity Zinc Sulfate - toxicity
Online-Zugang:	Volltext
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