Activation of CD74 inhibits migration of human mesenchymal stem cells
Therapeutic administration of mesenchymal stem cells (MSCs) by systemic delivery utilizes the innate ability of the cells to home to damaged tissues, but it can be an inefficient process due to a limited knowledge of cellular cues that regulate migration and homing. Our lab recently discovered that...
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| Veröffentlicht in: | In vitro cellular & developmental biology. Animal 2010-06, Vol.46 (6), p.566-572 |
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| container_title | In vitro cellular & developmental biology. Animal |
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| creator | Barrilleaux, Bonnie L Fischer-Valuck, Benjamin W Gilliam, Jennifer K Phinney, Donald G O'Connor, Kim C |
| description | Therapeutic administration of mesenchymal stem cells (MSCs) by systemic delivery utilizes the innate ability of the cells to home to damaged tissues, but it can be an inefficient process due to a limited knowledge of cellular cues that regulate migration and homing. Our lab recently discovered that a potent pro-inflammatory cytokine, macrophage migration inhibitory factor (MIF), inhibits MSC migration. Because MIF may act on multiple cellular targets, an activating antibody (CD74Ab) was employed in this study to examine the effect of one MIF receptor, CD74 (major histocompatibility complex class II-associated invariant chain), on MSC motility. CD74 activation inhibits in a dose-dependent manner up to 90% of in vitro migration of MSCs at 40 μg/ml CD74Ab (p |
| doi_str_mv | 10.1007/s11626-010-9279-1 |
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Our lab recently discovered that a potent pro-inflammatory cytokine, macrophage migration inhibitory factor (MIF), inhibits MSC migration. Because MIF may act on multiple cellular targets, an activating antibody (CD74Ab) was employed in this study to examine the effect of one MIF receptor, CD74 (major histocompatibility complex class II-associated invariant chain), on MSC motility. CD74 activation inhibits in a dose-dependent manner up to 90% of in vitro migration of MSCs at 40 μg/ml CD74Ab (p < 0.001), with consistent effects observed among three MSC donor preparations. A blocking peptide from the C-terminus of CD74 eliminates the effect of CD74Ab on MSCs. This suggests that MIF may act on MSCs, at least in part, through CD74. Late-passage MSCs exhibit less chemokinesis than those at passage 2. However, MSCs remain responsive to CD74 activation during ex vivo expansion: MSC migration is inhibited ∼2-fold in the presence of 5 µg/ml CD74Ab at passage 9 vs. ∼3-fold at passage 2 (p < 0.001). Consistent with this result, there were no significant differences in CD74 expression at all tested passages or after CD74Ab exposure. Targeting CD74 to regulate migration and homing potentially may be a useful strategy to improve the efficacy of a variety of MSC therapies, including those that require ex vivo expansion.</description><identifier>ISSN: 1071-2690</identifier><identifier>EISSN: 1543-706X</identifier><identifier>DOI: 10.1007/s11626-010-9279-1</identifier><identifier>PMID: 20198449</identifier><identifier>CODEN: IVCAED</identifier><language>eng</language><publisher>New York: New York : Springer-Verlag</publisher><subject>Animal Genetics and Genomics ; Animal migration behavior ; Antibodies ; Antigens, Differentiation, B-Lymphocyte - metabolism ; Biomedical and Life Sciences ; Bone marrow ; C-Terminus ; Cell Biology ; Cell Culture ; Cell Differentiation ; Cell migration ; Cell Movement ; Chemokinesis ; Cytokines ; Developmental Biology ; Fibroblasts ; Histocompatibility Antigens Class II - metabolism ; Homing ; Homing behavior ; Humans ; Inflammation ; Invariant chain ; Leukocyte migration ; Life Sciences ; Macrophage migration inhibitory factor ; Macrophages ; Major histocompatibility complex ; Medical treatment ; Mesenchymal stem cells ; Mesenchymal Stromal Cells - cytology ; Mesenchymal Stromal Cells - metabolism ; Mesenchyme ; Migration ; Motility ; Physiological regulation ; SIGNAL TRANSDUCTION ; Stem Cells</subject><ispartof>In vitro cellular & developmental biology. Animal, 2010-06, Vol.46 (6), p.566-572</ispartof><rights>2010 Society for In Vitro Biology</rights><rights>The Society for In Vitro Biology 2010</rights><rights>Copyright Society for In Vitro Biology Jun 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-9e7367889244c713de145d272b6c82ca487e60497b8cd60ea64a0583f917f1573</citedby><cites>FETCH-LOGICAL-c514t-9e7367889244c713de145d272b6c82ca487e60497b8cd60ea64a0583f917f1573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/40802396$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/40802396$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>315,781,785,804,27928,27929,41492,42561,51323,58021,58254</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20198449$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barrilleaux, Bonnie L</creatorcontrib><creatorcontrib>Fischer-Valuck, Benjamin W</creatorcontrib><creatorcontrib>Gilliam, Jennifer K</creatorcontrib><creatorcontrib>Phinney, Donald G</creatorcontrib><creatorcontrib>O'Connor, Kim C</creatorcontrib><title>Activation of CD74 inhibits migration of human mesenchymal stem cells</title><title>In vitro cellular & developmental biology. Animal</title><addtitle>In Vitro Cell.Dev.Biol.-Animal</addtitle><addtitle>In Vitro Cell Dev Biol Anim</addtitle><description>Therapeutic administration of mesenchymal stem cells (MSCs) by systemic delivery utilizes the innate ability of the cells to home to damaged tissues, but it can be an inefficient process due to a limited knowledge of cellular cues that regulate migration and homing. Our lab recently discovered that a potent pro-inflammatory cytokine, macrophage migration inhibitory factor (MIF), inhibits MSC migration. Because MIF may act on multiple cellular targets, an activating antibody (CD74Ab) was employed in this study to examine the effect of one MIF receptor, CD74 (major histocompatibility complex class II-associated invariant chain), on MSC motility. CD74 activation inhibits in a dose-dependent manner up to 90% of in vitro migration of MSCs at 40 μg/ml CD74Ab (p < 0.001), with consistent effects observed among three MSC donor preparations. A blocking peptide from the C-terminus of CD74 eliminates the effect of CD74Ab on MSCs. This suggests that MIF may act on MSCs, at least in part, through CD74. Late-passage MSCs exhibit less chemokinesis than those at passage 2. However, MSCs remain responsive to CD74 activation during ex vivo expansion: MSC migration is inhibited ∼2-fold in the presence of 5 µg/ml CD74Ab at passage 9 vs. ∼3-fold at passage 2 (p < 0.001). Consistent with this result, there were no significant differences in CD74 expression at all tested passages or after CD74Ab exposure. Targeting CD74 to regulate migration and homing potentially may be a useful strategy to improve the efficacy of a variety of MSC therapies, including those that require ex vivo expansion.</description><subject>Animal Genetics and Genomics</subject><subject>Animal migration behavior</subject><subject>Antibodies</subject><subject>Antigens, Differentiation, B-Lymphocyte - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Bone marrow</subject><subject>C-Terminus</subject><subject>Cell Biology</subject><subject>Cell Culture</subject><subject>Cell Differentiation</subject><subject>Cell migration</subject><subject>Cell Movement</subject><subject>Chemokinesis</subject><subject>Cytokines</subject><subject>Developmental Biology</subject><subject>Fibroblasts</subject><subject>Histocompatibility Antigens Class II - metabolism</subject><subject>Homing</subject><subject>Homing behavior</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Invariant chain</subject><subject>Leukocyte migration</subject><subject>Life Sciences</subject><subject>Macrophage migration inhibitory factor</subject><subject>Macrophages</subject><subject>Major histocompatibility complex</subject><subject>Medical treatment</subject><subject>Mesenchymal stem cells</subject><subject>Mesenchymal Stromal Cells - cytology</subject><subject>Mesenchymal Stromal Cells - metabolism</subject><subject>Mesenchyme</subject><subject>Migration</subject><subject>Motility</subject><subject>Physiological regulation</subject><subject>SIGNAL TRANSDUCTION</subject><subject>Stem Cells</subject><issn>1071-2690</issn><issn>1543-706X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkUtv1DAUhS1UREvhB3RBG7FhFXqv7fjay2ooD6kSC1qJneXxODMeTZLWTpD67_EoZSqxAG9s6Xw-93EYO0P4iAB0mREVVzUg1IaTqfEFO8FGippA_TwqbyCsuTJwzF7nvIVyDKpX7JgDGi2lOWHXV36Mv9wYh74a2mrxiWQV-01cxjFXXVyng7SZOtdXXcih95vHzu2qPIau8mG3y2_Yy9btcnj7dJ-yu8_Xt4uv9c33L98WVze1b1COtQkkFGltuJSeUKwCymbFiS-V19w7qSkokIaW2q8UBKekg0aL1iC12JA4ZR9m3_s0PEwhj7aLed-B68MwZWuACyLD8b8kCQHaNKgL-f4vcjtMqS9jWAXGkFbQFAhnyKch5xRae59i59KjRbD7LOychS1Z2H0Wdt_C-ZPxtOzC6vDjz_ILwGcgF6lfh_Rc-V-u7-ZP2zwO6WAqQZfZjSr6xay3brBunWK2dz9KSQGopRZlm78BkEej5A</recordid><startdate>20100601</startdate><enddate>20100601</enddate><creator>Barrilleaux, Bonnie L</creator><creator>Fischer-Valuck, Benjamin W</creator><creator>Gilliam, Jennifer K</creator><creator>Phinney, Donald G</creator><creator>O'Connor, Kim C</creator><general>New York : Springer-Verlag</general><general>Springer Science + Business Media</general><general>Springer-Verlag</general><general>Society for In Vitro Biology</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>20100601</creationdate><title>Activation of CD74 inhibits migration of human mesenchymal stem cells</title><author>Barrilleaux, Bonnie L ; Fischer-Valuck, Benjamin W ; Gilliam, Jennifer K ; Phinney, Donald G ; O'Connor, Kim C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-9e7367889244c713de145d272b6c82ca487e60497b8cd60ea64a0583f917f1573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animal Genetics and Genomics</topic><topic>Animal migration behavior</topic><topic>Antibodies</topic><topic>Antigens, Differentiation, B-Lymphocyte - metabolism</topic><topic>Biomedical and Life Sciences</topic><topic>Bone marrow</topic><topic>C-Terminus</topic><topic>Cell Biology</topic><topic>Cell Culture</topic><topic>Cell Differentiation</topic><topic>Cell migration</topic><topic>Cell Movement</topic><topic>Chemokinesis</topic><topic>Cytokines</topic><topic>Developmental Biology</topic><topic>Fibroblasts</topic><topic>Histocompatibility Antigens Class II - metabolism</topic><topic>Homing</topic><topic>Homing behavior</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Invariant chain</topic><topic>Leukocyte migration</topic><topic>Life Sciences</topic><topic>Macrophage migration inhibitory factor</topic><topic>Macrophages</topic><topic>Major histocompatibility complex</topic><topic>Medical treatment</topic><topic>Mesenchymal stem cells</topic><topic>Mesenchymal Stromal Cells - cytology</topic><topic>Mesenchymal Stromal Cells - metabolism</topic><topic>Mesenchyme</topic><topic>Migration</topic><topic>Motility</topic><topic>Physiological regulation</topic><topic>SIGNAL TRANSDUCTION</topic><topic>Stem Cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barrilleaux, Bonnie L</creatorcontrib><creatorcontrib>Fischer-Valuck, Benjamin W</creatorcontrib><creatorcontrib>Gilliam, Jennifer K</creatorcontrib><creatorcontrib>Phinney, Donald G</creatorcontrib><creatorcontrib>O'Connor, Kim C</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>Proquest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - 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Animal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barrilleaux, Bonnie L</au><au>Fischer-Valuck, Benjamin W</au><au>Gilliam, Jennifer K</au><au>Phinney, Donald G</au><au>O'Connor, Kim C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activation of CD74 inhibits migration of human mesenchymal stem cells</atitle><jtitle>In vitro cellular & developmental biology. Animal</jtitle><stitle>In Vitro Cell.Dev.Biol.-Animal</stitle><addtitle>In Vitro Cell Dev Biol Anim</addtitle><date>2010-06-01</date><risdate>2010</risdate><volume>46</volume><issue>6</issue><spage>566</spage><epage>572</epage><pages>566-572</pages><issn>1071-2690</issn><eissn>1543-706X</eissn><coden>IVCAED</coden><abstract>Therapeutic administration of mesenchymal stem cells (MSCs) by systemic delivery utilizes the innate ability of the cells to home to damaged tissues, but it can be an inefficient process due to a limited knowledge of cellular cues that regulate migration and homing. Our lab recently discovered that a potent pro-inflammatory cytokine, macrophage migration inhibitory factor (MIF), inhibits MSC migration. Because MIF may act on multiple cellular targets, an activating antibody (CD74Ab) was employed in this study to examine the effect of one MIF receptor, CD74 (major histocompatibility complex class II-associated invariant chain), on MSC motility. CD74 activation inhibits in a dose-dependent manner up to 90% of in vitro migration of MSCs at 40 μg/ml CD74Ab (p < 0.001), with consistent effects observed among three MSC donor preparations. A blocking peptide from the C-terminus of CD74 eliminates the effect of CD74Ab on MSCs. This suggests that MIF may act on MSCs, at least in part, through CD74. Late-passage MSCs exhibit less chemokinesis than those at passage 2. However, MSCs remain responsive to CD74 activation during ex vivo expansion: MSC migration is inhibited ∼2-fold in the presence of 5 µg/ml CD74Ab at passage 9 vs. ∼3-fold at passage 2 (p < 0.001). Consistent with this result, there were no significant differences in CD74 expression at all tested passages or after CD74Ab exposure. Targeting CD74 to regulate migration and homing potentially may be a useful strategy to improve the efficacy of a variety of MSC therapies, including those that require ex vivo expansion.</abstract><cop>New York</cop><pub>New York : Springer-Verlag</pub><pmid>20198449</pmid><doi>10.1007/s11626-010-9279-1</doi><tpages>7</tpages></addata></record> |
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| subjects | Animal Genetics and Genomics Animal migration behavior Antibodies Antigens, Differentiation, B-Lymphocyte - metabolism Biomedical and Life Sciences Bone marrow C-Terminus Cell Biology Cell Culture Cell Differentiation Cell migration Cell Movement Chemokinesis Cytokines Developmental Biology Fibroblasts Histocompatibility Antigens Class II - metabolism Homing Homing behavior Humans Inflammation Invariant chain Leukocyte migration Life Sciences Macrophage migration inhibitory factor Macrophages Major histocompatibility complex Medical treatment Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Mesenchyme Migration Motility Physiological regulation SIGNAL TRANSDUCTION Stem Cells |
| title | Activation of CD74 inhibits migration of human mesenchymal stem cells |
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