Embryotoxicity and Biotransformation Responses in Zebrafish Exposed to Water-Soluble Fraction of Crude Oil
The toxic effects of water-soluble fraction (WSF) of crude oil (API27, Petrobras Campos Basin, Brazil) were evaluated during the early life stages of zebrafish, as well as its biotransformation in juvenile fish. Embryonic development was studied during 96 h. Reduced heartbeat rate, weak pigmentation...
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| Veröffentlicht in: | Bulletin of environmental contamination and toxicology 2011-04, Vol.86 (4), p.389-393 |
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| creator | Pauka, Luciana M. Maceno, Marcell Rossi, Stefani C. Silva de Assis, Helena C. |
| description | The toxic effects of water-soluble fraction (WSF) of crude oil (API27, Petrobras Campos Basin, Brazil) were evaluated during the early life stages of zebrafish, as well as its biotransformation in juvenile fish. Embryonic development was studied during 96 h. Reduced heartbeat rate, weak pigmentation, tail defects, and embryo mortality were observed for all of the tested concentrations of the WSF. Activities of the biotransformation enzymes were induced at the highest concentrations, showing that these enzymes played a role in its elimination. As shown in this study the crude oil WSF altered the normal embryonic development of fish. |
| doi_str_mv | 10.1007/s00128-011-0235-x |
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Embryonic development was studied during 96 h. Reduced heartbeat rate, weak pigmentation, tail defects, and embryo mortality were observed for all of the tested concentrations of the WSF. Activities of the biotransformation enzymes were induced at the highest concentrations, showing that these enzymes played a role in its elimination. 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Embryonic development was studied during 96 h. Reduced heartbeat rate, weak pigmentation, tail defects, and embryo mortality were observed for all of the tested concentrations of the WSF. Activities of the biotransformation enzymes were induced at the highest concentrations, showing that these enzymes played a role in its elimination. As shown in this study the crude oil WSF altered the normal embryonic development of fish.</description><subject>Abnormalities, Drug-Induced - embryology</subject><subject>Abnormalities, Drug-Induced - metabolism</subject><subject>Animals</subject><subject>Aquatic Pollution</subject><subject>Biotransformation</subject><subject>Crude oil</subject><subject>Cytochrome P-450 CYP1A1 - metabolism</subject><subject>Danio rerio</subject><subject>Dose-Response Relationship, Drug</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Embryo, Nonmammalian - drug effects</subject><subject>Embryo, Nonmammalian - metabolism</subject><subject>Embryonic growth stage</subject><subject>Embryos</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Fish</subject><subject>Freshwater</subject><subject>Glutathione Transferase - metabolism</subject><subject>Petroleum - toxicity</subject><subject>Pigmentation</subject><subject>Pollution</subject><subject>Soil Science & Conservation</subject><subject>Toxicity</subject><subject>Waste Water Technology</subject><subject>Water</subject><subject>Water Management</subject><subject>Water Pollutants, Chemical - 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| ispartof | Bulletin of environmental contamination and toxicology, 2011-04, Vol.86 (4), p.389-393 |
| issn | 0007-4861 1432-0800 |
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| subjects | Abnormalities, Drug-Induced - embryology Abnormalities, Drug-Induced - metabolism Animals Aquatic Pollution Biotransformation Crude oil Cytochrome P-450 CYP1A1 - metabolism Danio rerio Dose-Response Relationship, Drug Earth and Environmental Science Ecotoxicology Embryo, Nonmammalian - drug effects Embryo, Nonmammalian - metabolism Embryonic growth stage Embryos Environment Environmental Chemistry Environmental Health Fish Freshwater Glutathione Transferase - metabolism Petroleum - toxicity Pigmentation Pollution Soil Science & Conservation Toxicity Waste Water Technology Water Water Management Water Pollutants, Chemical - toxicity Water Pollution Control Zebrafish - embryology Zebrafish - metabolism |
| title | Embryotoxicity and Biotransformation Responses in Zebrafish Exposed to Water-Soluble Fraction of Crude Oil |
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