CXCL12/CXCR4 signaling in malignant brain tumors: a potential pharmacological therapeutic target
Chemokines are 8- to 12-kDa peptides that function as chemoattractant cytokines involved in cell activation, differentiation, and trafficking. Chemokines bind to specific G-protein-coupled, seven-span transmembrane receptors on the plasma membrane of target cells. Chemokine (C-X-C motif) ligand 12 (...
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| Veröffentlicht in: | Brain tumor pathology 2011-04, Vol.28 (2), p.89-97 |
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| creator | Terasaki, Mizuhiko Sugita, Yasuo Arakawa, Fumiko Okada, Yosuke Ohshima, Koichi Shigemori, Minoru |
| description | Chemokines are 8- to 12-kDa peptides that function as chemoattractant cytokines involved in cell activation, differentiation, and trafficking. Chemokines bind to specific G-protein-coupled, seven-span transmembrane receptors on the plasma membrane of target cells. Chemokine (C-X-C motif) ligand 12 (CXCL12), an alpha-chemokine that binds to G-protein-coupled chemokine (C-X-C motif) receptor 4 (CXCR4), plays an important and unique role in the regulation of stem/progenitor-cell trafficking. As CXCR4 is expressed on several cancer cells, these CXCR4-positive cancer cells may metastasize to organs that secrete/express CXCL12. Regarding brain tumors, recent data demonstrate that glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via the CXCL12/CXCR4 pathway. In addition, CXCL12/CXCR4 have recently been shown to be expressed in primary central nervous system (PCNS) lymphomas, and a role for chemokines in the pathogenesis of PCNS lymphomas was suggested. This review focuses on current knowledge regarding the biology of the CXCL12/CXCR4 pathway in the context of understanding their potential role in malignant gliomas and PCNS lymphoma development. The CXCL12/CXCR4 interaction as a therapeutic target for malignant brain tumors is also discussed. |
| doi_str_mv | 10.1007/s10014-010-0013-1 |
| format | Article |
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Chemokines bind to specific G-protein-coupled, seven-span transmembrane receptors on the plasma membrane of target cells. Chemokine (C-X-C motif) ligand 12 (CXCL12), an alpha-chemokine that binds to G-protein-coupled chemokine (C-X-C motif) receptor 4 (CXCR4), plays an important and unique role in the regulation of stem/progenitor-cell trafficking. As CXCR4 is expressed on several cancer cells, these CXCR4-positive cancer cells may metastasize to organs that secrete/express CXCL12. Regarding brain tumors, recent data demonstrate that glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via the CXCL12/CXCR4 pathway. In addition, CXCL12/CXCR4 have recently been shown to be expressed in primary central nervous system (PCNS) lymphomas, and a role for chemokines in the pathogenesis of PCNS lymphomas was suggested. This review focuses on current knowledge regarding the biology of the CXCL12/CXCR4 pathway in the context of understanding their potential role in malignant gliomas and PCNS lymphoma development. The CXCL12/CXCR4 interaction as a therapeutic target for malignant brain tumors is also discussed.</description><identifier>ISSN: 1433-7398</identifier><identifier>EISSN: 1861-387X</identifier><identifier>DOI: 10.1007/s10014-010-0013-1</identifier><identifier>PMID: 21210239</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Angiogenesis ; Bone marrow ; Brain cancer ; Brain Neoplasms - drug therapy ; Brain Neoplasms - metabolism ; Brain Neoplasms - pathology ; Cancer Research ; Cell Movement - drug effects ; Cell Movement - physiology ; Cells ; Chemokine CXCL12 - metabolism ; Chemokines ; Extracellular matrix ; Glioblastoma - metabolism ; Glioblastoma - pathology ; Glioma ; Heterocyclic Compounds - pharmacology ; Heterocyclic Compounds - therapeutic use ; Humans ; Ligands ; Lymphatic system ; Lymphoma ; Lymphoma - drug therapy ; Lymphoma - metabolism ; Lymphoma - pathology ; Medical prognosis ; Medicine ; Medicine & Public Health ; Metastasis ; Neoplasm Metastasis ; Neurology ; Neurosurgery ; Oncology ; Ovaries ; Pancreatic cancer ; Pathology ; Protein Binding ; Receptors, CXCR4 - antagonists & inhibitors ; Receptors, CXCR4 - metabolism ; Review Article ; Sarcoma ; Signal Transduction - drug effects ; Stem Cells - metabolism ; Stem Cells - pathology ; Tumor necrosis factor-TNF ; Tumors ; Vascular endothelial growth factor</subject><ispartof>Brain tumor pathology, 2011-04, Vol.28 (2), p.89-97</ispartof><rights>The Japan Society of Brain Tumor Pathology 2010</rights><rights>The Japan Society of Brain Tumor Pathology 2010.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-61a2a9b2cf144dd39b7716926bf8c5d366ea76eb6a8fb0e0a190b3967589dccd3</citedby><cites>FETCH-LOGICAL-c427t-61a2a9b2cf144dd39b7716926bf8c5d366ea76eb6a8fb0e0a190b3967589dccd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10014-010-0013-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2917939119?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,21368,21369,27903,27904,33509,33510,33723,33724,41467,42536,43638,43784,51298,64362,64364,64366,72216</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21210239$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Terasaki, Mizuhiko</creatorcontrib><creatorcontrib>Sugita, Yasuo</creatorcontrib><creatorcontrib>Arakawa, Fumiko</creatorcontrib><creatorcontrib>Okada, Yosuke</creatorcontrib><creatorcontrib>Ohshima, Koichi</creatorcontrib><creatorcontrib>Shigemori, Minoru</creatorcontrib><title>CXCL12/CXCR4 signaling in malignant brain tumors: a potential pharmacological therapeutic target</title><title>Brain tumor pathology</title><addtitle>Brain Tumor Pathol</addtitle><addtitle>Brain Tumor Pathol</addtitle><description>Chemokines are 8- to 12-kDa peptides that function as chemoattractant cytokines involved in cell activation, differentiation, and trafficking. Chemokines bind to specific G-protein-coupled, seven-span transmembrane receptors on the plasma membrane of target cells. Chemokine (C-X-C motif) ligand 12 (CXCL12), an alpha-chemokine that binds to G-protein-coupled chemokine (C-X-C motif) receptor 4 (CXCR4), plays an important and unique role in the regulation of stem/progenitor-cell trafficking. As CXCR4 is expressed on several cancer cells, these CXCR4-positive cancer cells may metastasize to organs that secrete/express CXCL12. Regarding brain tumors, recent data demonstrate that glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via the CXCL12/CXCR4 pathway. In addition, CXCL12/CXCR4 have recently been shown to be expressed in primary central nervous system (PCNS) lymphomas, and a role for chemokines in the pathogenesis of PCNS lymphomas was suggested. This review focuses on current knowledge regarding the biology of the CXCL12/CXCR4 pathway in the context of understanding their potential role in malignant gliomas and PCNS lymphoma development. The CXCL12/CXCR4 interaction as a therapeutic target for malignant brain tumors is also discussed.</description><subject>Angiogenesis</subject><subject>Bone marrow</subject><subject>Brain cancer</subject><subject>Brain Neoplasms - drug therapy</subject><subject>Brain Neoplasms - metabolism</subject><subject>Brain Neoplasms - pathology</subject><subject>Cancer Research</subject><subject>Cell Movement - drug effects</subject><subject>Cell Movement - physiology</subject><subject>Cells</subject><subject>Chemokine CXCL12 - metabolism</subject><subject>Chemokines</subject><subject>Extracellular matrix</subject><subject>Glioblastoma - metabolism</subject><subject>Glioblastoma - pathology</subject><subject>Glioma</subject><subject>Heterocyclic Compounds - pharmacology</subject><subject>Heterocyclic Compounds - therapeutic use</subject><subject>Humans</subject><subject>Ligands</subject><subject>Lymphatic system</subject><subject>Lymphoma</subject><subject>Lymphoma - drug therapy</subject><subject>Lymphoma - metabolism</subject><subject>Lymphoma - pathology</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastasis</subject><subject>Neoplasm Metastasis</subject><subject>Neurology</subject><subject>Neurosurgery</subject><subject>Oncology</subject><subject>Ovaries</subject><subject>Pancreatic cancer</subject><subject>Pathology</subject><subject>Protein Binding</subject><subject>Receptors, CXCR4 - antagonists & inhibitors</subject><subject>Receptors, CXCR4 - metabolism</subject><subject>Review Article</subject><subject>Sarcoma</subject><subject>Signal Transduction - drug effects</subject><subject>Stem Cells - metabolism</subject><subject>Stem Cells - pathology</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumors</subject><subject>Vascular endothelial growth factor</subject><issn>1433-7398</issn><issn>1861-387X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkUtLxDAUhYMozvj4AW6k4MJVndykkzTupPiCAUEUZhfTNO106MskXfjvzTCjgiBucu8h3z2X5CB0BvgKMOYzF05IYgw4Dg2NYQ9NIWUQ05Qv90OfUBpzKtIJOnJujXGSYA6HaEKAACZUTNFbtswWQGahPCeRq6tONXVXRXUXtaELsvNRblXQfmx7664jFQ29N52vVRMNK2Vbpfumr2odtF8ZqwYz-lpHXtnK-BN0UKrGmdNdPUavd7cv2UO8eLp_zG4WsU4I9zEDRZTIiS4hSYqCipxzYIKwvEz1vKCMGcWZyZlKyxwbrEDgnArG56kotC7oMbrc-g62fx-N87KtnTZNozrTj06K8F6-wf8lU0YYpkBZIC9-ket-tOGHnCQCuKACQAQKtpS2vXPWlHKwdavshwQsNznJbU4y5CQ3OUkIM-c75zFvTfE98RVMAMgWcOGqq4z9Wf236yfGGZxD</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Terasaki, Mizuhiko</creator><creator>Sugita, Yasuo</creator><creator>Arakawa, Fumiko</creator><creator>Okada, Yosuke</creator><creator>Ohshima, Koichi</creator><creator>Shigemori, Minoru</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20110401</creationdate><title>CXCL12/CXCR4 signaling in malignant brain tumors: a potential pharmacological therapeutic target</title><author>Terasaki, Mizuhiko ; 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Chemokines bind to specific G-protein-coupled, seven-span transmembrane receptors on the plasma membrane of target cells. Chemokine (C-X-C motif) ligand 12 (CXCL12), an alpha-chemokine that binds to G-protein-coupled chemokine (C-X-C motif) receptor 4 (CXCR4), plays an important and unique role in the regulation of stem/progenitor-cell trafficking. As CXCR4 is expressed on several cancer cells, these CXCR4-positive cancer cells may metastasize to organs that secrete/express CXCL12. Regarding brain tumors, recent data demonstrate that glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via the CXCL12/CXCR4 pathway. In addition, CXCL12/CXCR4 have recently been shown to be expressed in primary central nervous system (PCNS) lymphomas, and a role for chemokines in the pathogenesis of PCNS lymphomas was suggested. This review focuses on current knowledge regarding the biology of the CXCL12/CXCR4 pathway in the context of understanding their potential role in malignant gliomas and PCNS lymphoma development. The CXCL12/CXCR4 interaction as a therapeutic target for malignant brain tumors is also discussed.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>21210239</pmid><doi>10.1007/s10014-010-0013-1</doi><tpages>9</tpages></addata></record> |
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| subjects | Angiogenesis Bone marrow Brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - metabolism Brain Neoplasms - pathology Cancer Research Cell Movement - drug effects Cell Movement - physiology Cells Chemokine CXCL12 - metabolism Chemokines Extracellular matrix Glioblastoma - metabolism Glioblastoma - pathology Glioma Heterocyclic Compounds - pharmacology Heterocyclic Compounds - therapeutic use Humans Ligands Lymphatic system Lymphoma Lymphoma - drug therapy Lymphoma - metabolism Lymphoma - pathology Medical prognosis Medicine Medicine & Public Health Metastasis Neoplasm Metastasis Neurology Neurosurgery Oncology Ovaries Pancreatic cancer Pathology Protein Binding Receptors, CXCR4 - antagonists & inhibitors Receptors, CXCR4 - metabolism Review Article Sarcoma Signal Transduction - drug effects Stem Cells - metabolism Stem Cells - pathology Tumor necrosis factor-TNF Tumors Vascular endothelial growth factor |
| title | CXCL12/CXCR4 signaling in malignant brain tumors: a potential pharmacological therapeutic target |
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