Evaluating the Relationship Between Postmortem and Antemortem Morphine and Codeine Concentrations in Whole Blood
The purpose of this study was to examine the relationship between antemortem (AM) and postmortem (PM) morphine and codeine concentrations in whole blood. In addition, the effects of antemortem to death interval as well as the postmortem interval were considered during the interpretive process. The c...
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| Veröffentlicht in: | Journal of analytical toxicology 2010-10, Vol.34 (8), p.491-497 |
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| container_title | Journal of analytical toxicology |
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| creator | Tolliver, Samantha S. Hearn, W. Lee Furton, Kenneth G. |
| description | The purpose of this study was to examine the relationship between antemortem (AM) and postmortem (PM) morphine and codeine concentrations in whole blood. In addition, the effects of antemortem to death interval as well as the postmortem interval were considered during the interpretive process. The cases of seven human subjects are presented here with an average postmortem interval of 28 h (13.5–48 h) and an average antemortem to death interval of 97 min (ranging from 9 to 300 min). Drug concentrations were obtained from AM blood collected from local hospitals in Miami, FL, and postmortem blood was obtained from the Miami-Dade County Medical Examiner Department in Miami, FL. The results obtained for this study indicated that factors such as metabolism and postmortem interval can affect postmortem drug concentrations in an unpredictable manner. Four out of seven morphine cases appeared to be affected by postmortem redistribution, and five of seven codeine and two of two 6-monoacetylmorphine cases were affected as well. |
| doi_str_mv | 10.1093/jat/34.8.491 |
| format | Article |
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Lee ; Furton, Kenneth G.</creator><creatorcontrib>Tolliver, Samantha S. ; Hearn, W. Lee ; Furton, Kenneth G.</creatorcontrib><description>The purpose of this study was to examine the relationship between antemortem (AM) and postmortem (PM) morphine and codeine concentrations in whole blood. In addition, the effects of antemortem to death interval as well as the postmortem interval were considered during the interpretive process. The cases of seven human subjects are presented here with an average postmortem interval of 28 h (13.5–48 h) and an average antemortem to death interval of 97 min (ranging from 9 to 300 min). Drug concentrations were obtained from AM blood collected from local hospitals in Miami, FL, and postmortem blood was obtained from the Miami-Dade County Medical Examiner Department in Miami, FL. The results obtained for this study indicated that factors such as metabolism and postmortem interval can affect postmortem drug concentrations in an unpredictable manner. Four out of seven morphine cases appeared to be affected by postmortem redistribution, and five of seven codeine and two of two 6-monoacetylmorphine cases were affected as well.</description><identifier>ISSN: 0146-4760</identifier><identifier>EISSN: 1945-2403</identifier><identifier>DOI: 10.1093/jat/34.8.491</identifier><identifier>PMID: 21819794</identifier><identifier>CODEN: JATOD3</identifier><language>eng</language><publisher>Niles, IL: Oxford University Press</publisher><subject>Adult ; Aged, 80 and over ; Analysis ; Autopsy ; Biological and medical sciences ; Codeine - analogs & derivatives ; Codeine - blood ; Codeine - pharmacokinetics ; Gas Chromatography-Mass Spectrometry ; General pharmacology ; Humans ; Male ; Medical sciences ; Middle Aged ; Morphine - blood ; Morphine - pharmacokinetics ; Morphine Derivatives - blood ; Narcotics - blood ; Narcotics - pharmacokinetics ; Pharmacology. Drug treatments ; Substance Abuse Detection ; Time Factors</subject><ispartof>Journal of analytical toxicology, 2010-10, Vol.34 (8), p.491-497</ispartof><rights>2010</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-fec1f866d35234a3a9bd80e7e1d43f3f3ea7fee0ade5b905a14ddcfc9b2658383</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,1581,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23280751$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21819794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tolliver, Samantha S.</creatorcontrib><creatorcontrib>Hearn, W. Lee</creatorcontrib><creatorcontrib>Furton, Kenneth G.</creatorcontrib><title>Evaluating the Relationship Between Postmortem and Antemortem Morphine and Codeine Concentrations in Whole Blood</title><title>Journal of analytical toxicology</title><addtitle>Journal of Analytical Toxicology</addtitle><addtitle>Journal of Analytical Toxicology</addtitle><description>The purpose of this study was to examine the relationship between antemortem (AM) and postmortem (PM) morphine and codeine concentrations in whole blood. In addition, the effects of antemortem to death interval as well as the postmortem interval were considered during the interpretive process. The cases of seven human subjects are presented here with an average postmortem interval of 28 h (13.5–48 h) and an average antemortem to death interval of 97 min (ranging from 9 to 300 min). Drug concentrations were obtained from AM blood collected from local hospitals in Miami, FL, and postmortem blood was obtained from the Miami-Dade County Medical Examiner Department in Miami, FL. The results obtained for this study indicated that factors such as metabolism and postmortem interval can affect postmortem drug concentrations in an unpredictable manner. Four out of seven morphine cases appeared to be affected by postmortem redistribution, and five of seven codeine and two of two 6-monoacetylmorphine cases were affected as well.</description><subject>Adult</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Autopsy</subject><subject>Biological and medical sciences</subject><subject>Codeine - analogs & derivatives</subject><subject>Codeine - blood</subject><subject>Codeine - pharmacokinetics</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Morphine - blood</subject><subject>Morphine - pharmacokinetics</subject><subject>Morphine Derivatives - blood</subject><subject>Narcotics - blood</subject><subject>Narcotics - pharmacokinetics</subject><subject>Pharmacology. Drug treatments</subject><subject>Substance Abuse Detection</subject><subject>Time Factors</subject><issn>0146-4760</issn><issn>1945-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1v1DAQBmALUdGlcOOMfEFcyNaOP2If2-2n1AqEikBcLG88YVMSO7Ud2v57UrK0x8oHz1iPXlsehN5RsqREs_1rm_cZX6ol1_QFWlDNRVFywl6iBaFcFrySZBe9TumaECqVZK_QbkkV1ZXmCzQc_7HdaHPrf-G8AfwVuqkJPm3aAR9CvgXw-EtIuQ8xQ4-td_jAT9XcXoY4bFoP_85XwcFDvQq-Bp_jHIRbj79vQgf4sAvBvUE7je0SvN3ue-jbyfHV6qy4-Hx6vjq4KGpRylw0UNNGSemYKBm3zOq1UwQqoI6zZlpgqwaAWAdirYmwlDtXN7Vel1Ioptge-jjnDjHcjJCy6dtUQ9dZD2FMRpOSVVKW4lmpNJsyGZWT_DTLOoaUIjRmiG1v472hxDwMw0zDMIwbZaZhTPz9Nnhc9-Ae8f_fn8CHLbCptl0Tra_b9ORYqUgl6NMLwzg8d2UxyzZluHu0Nv42smKVMGc_fpqro-pIicsTw9hfTW-v8w</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>Tolliver, Samantha S.</creator><creator>Hearn, W. Lee</creator><creator>Furton, Kenneth G.</creator><general>Oxford University Press</general><general>Preston Publications</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20101001</creationdate><title>Evaluating the Relationship Between Postmortem and Antemortem Morphine and Codeine Concentrations in Whole Blood</title><author>Tolliver, Samantha S. ; Hearn, W. Lee ; Furton, Kenneth G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-fec1f866d35234a3a9bd80e7e1d43f3f3ea7fee0ade5b905a14ddcfc9b2658383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Autopsy</topic><topic>Biological and medical sciences</topic><topic>Codeine - analogs & derivatives</topic><topic>Codeine - blood</topic><topic>Codeine - pharmacokinetics</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Morphine - blood</topic><topic>Morphine - pharmacokinetics</topic><topic>Morphine Derivatives - blood</topic><topic>Narcotics - blood</topic><topic>Narcotics - pharmacokinetics</topic><topic>Pharmacology. Drug treatments</topic><topic>Substance Abuse Detection</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tolliver, Samantha S.</creatorcontrib><creatorcontrib>Hearn, W. Lee</creatorcontrib><creatorcontrib>Furton, Kenneth G.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of analytical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tolliver, Samantha S.</au><au>Hearn, W. 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The cases of seven human subjects are presented here with an average postmortem interval of 28 h (13.5–48 h) and an average antemortem to death interval of 97 min (ranging from 9 to 300 min). Drug concentrations were obtained from AM blood collected from local hospitals in Miami, FL, and postmortem blood was obtained from the Miami-Dade County Medical Examiner Department in Miami, FL. The results obtained for this study indicated that factors such as metabolism and postmortem interval can affect postmortem drug concentrations in an unpredictable manner. Four out of seven morphine cases appeared to be affected by postmortem redistribution, and five of seven codeine and two of two 6-monoacetylmorphine cases were affected as well.</abstract><cop>Niles, IL</cop><pub>Oxford University Press</pub><pmid>21819794</pmid><doi>10.1093/jat/34.8.491</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of analytical toxicology, 2010-10, Vol.34 (8), p.491-497 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adult Aged, 80 and over Analysis Autopsy Biological and medical sciences Codeine - analogs & derivatives Codeine - blood Codeine - pharmacokinetics Gas Chromatography-Mass Spectrometry General pharmacology Humans Male Medical sciences Middle Aged Morphine - blood Morphine - pharmacokinetics Morphine Derivatives - blood Narcotics - blood Narcotics - pharmacokinetics Pharmacology. Drug treatments Substance Abuse Detection Time Factors |
| title | Evaluating the Relationship Between Postmortem and Antemortem Morphine and Codeine Concentrations in Whole Blood |
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