Dimethylamylamine: A Drug Causing Positive Immunoassay Results for Amphetamines
The Department of Defense (DoD) operates six forensic urine drug-testing laboratories that screen close to 5 million urine samples for amphetamines yearly. Recently, the DoD laboratories have observed a significant decrease in the confirmation rates for amphetamines because of specimens screening po...
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| Veröffentlicht in: | Journal of analytical toxicology 2011-04, Vol.35 (3), p.183-187 |
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| container_title | Journal of analytical toxicology |
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| creator | Vorce, Shawn P. Holler, Justin M. Cawrse, Brian M. Magluilo, Joseph |
| description | The Department of Defense (DoD) operates six forensic urine drug-testing laboratories that screen close to 5 million urine samples for amphetamines yearly. Recently, the DoD laboratories have observed a significant decrease in the confirmation rates for amphetamines because of specimens screening positive by two separate immunoassays and confirming negative by gas chromatography-mass spectrometry (GC-MS). Previous studies conducted by the Division of Forensic Toxicology, Armed Force Institute of Pathology (AFIP) utilizing a GC-MS basic drug screen and a designer drug screen revealed no common compound or compound classes as to the cause of the immunoassay-positive results. Additional information obtained from an immunoassay vendor suggested the anorectic compound dimethylamylamine (DMAA) may be the cause of the false-positive screens. An additional 134 false-positive samples were received and analyzed using liquid chromatography-tandem mass spectrometry (LC-MS-MS) for DMAA. LC-MS-MS analysis revealed the presence of DMAA in 92.3% of the false-positive samples at a concentration of approximately 6.0 mg/L DMAA, causing a positive screen on both immunoassay kits. |
| doi_str_mv | 10.1093/anatox/35.3.183 |
| format | Article |
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LC-MS-MS analysis revealed the presence of DMAA in 92.3% of the false-positive samples at a concentration of approximately 6.0 mg/L DMAA, causing a positive screen on both immunoassay kits.</description><identifier>ISSN: 0146-4760</identifier><identifier>EISSN: 1945-2403</identifier><identifier>DOI: 10.1093/anatox/35.3.183</identifier><identifier>PMID: 21439156</identifier><identifier>CODEN: JATOD3</identifier><language>eng</language><publisher>Niles, IL: Oxford University Press</publisher><subject>Amines ; Amphetamines - urine ; Appetite Depressants - metabolism ; Biological and medical sciences ; Chromatography, Liquid ; Drug addictions ; False Positive Reactions ; Humans ; Immunoassay ; Medical sciences ; Substance Abuse Detection - methods ; Substance Abuse Detection - standards ; Tandem Mass Spectrometry ; Toxicology</subject><ispartof>Journal of analytical toxicology, 2011-04, Vol.35 (3), p.183-187</ispartof><rights>2011</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-8624d9486c43e317c25690f3bac4b9d16226c1f13534d9b7a7ac0daffd31a203</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23943350$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21439156$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vorce, Shawn P.</creatorcontrib><creatorcontrib>Holler, Justin M.</creatorcontrib><creatorcontrib>Cawrse, Brian M.</creatorcontrib><creatorcontrib>Magluilo, Joseph</creatorcontrib><title>Dimethylamylamine: A Drug Causing Positive Immunoassay Results for Amphetamines</title><title>Journal of analytical toxicology</title><addtitle>Journal of Analytical Toxicology</addtitle><addtitle>J Anal Toxicol</addtitle><description>The Department of Defense (DoD) operates six forensic urine drug-testing laboratories that screen close to 5 million urine samples for amphetamines yearly. Recently, the DoD laboratories have observed a significant decrease in the confirmation rates for amphetamines because of specimens screening positive by two separate immunoassays and confirming negative by gas chromatography-mass spectrometry (GC-MS). Previous studies conducted by the Division of Forensic Toxicology, Armed Force Institute of Pathology (AFIP) utilizing a GC-MS basic drug screen and a designer drug screen revealed no common compound or compound classes as to the cause of the immunoassay-positive results. Additional information obtained from an immunoassay vendor suggested the anorectic compound dimethylamylamine (DMAA) may be the cause of the false-positive screens. An additional 134 false-positive samples were received and analyzed using liquid chromatography-tandem mass spectrometry (LC-MS-MS) for DMAA. LC-MS-MS analysis revealed the presence of DMAA in 92.3% of the false-positive samples at a concentration of approximately 6.0 mg/L DMAA, causing a positive screen on both immunoassay kits.</description><subject>Amines</subject><subject>Amphetamines - urine</subject><subject>Appetite Depressants - metabolism</subject><subject>Biological and medical sciences</subject><subject>Chromatography, Liquid</subject><subject>Drug addictions</subject><subject>False Positive Reactions</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Medical sciences</subject><subject>Substance Abuse Detection - methods</subject><subject>Substance Abuse Detection - standards</subject><subject>Tandem Mass Spectrometry</subject><subject>Toxicology</subject><issn>0146-4760</issn><issn>1945-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0EtLxDAQB_Agiq6PszfpRQShu0kmSRtvy_oEQRHvYTZNtdLH2mnF_fZ23VWPHoa5_GaG-TN2LPhYcAsTrLFrPiegxzAWKWyxkbBKx1Jx2GYjLpSJVWL4HtsneuNcmNTALtuTQoEV2ozYw2VRhe51WWK1qqIOF9E0umz7l2iGPRX1S_TYUNEVHyG6q6q-bpAIl9FToL7sKMqbNppWi9fQfQ_TIdvJsaRwtOkH7Pn66nl2G98_3NzNpvexBwtdnBqpMqtS4xUEEImX2liewxy9mttMGCmNF7kADYObJ5ig5xnmeQYCJYcDdrZeu2ib9z5Q56qCfChLrEPTk7NcQmL08OZ_MtWWaxAgBzlZS982RG3I3aItKmyXTnC3Stut03agHbgh7WHiZLO7n1ch-_U_8Q7gdAOQPJZ5i7Uv6M-BVQB69c752jX94t-rX3gEluE</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Vorce, Shawn P.</creator><creator>Holler, Justin M.</creator><creator>Cawrse, Brian M.</creator><creator>Magluilo, Joseph</creator><general>Oxford University Press</general><general>Preston Publications</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20110401</creationdate><title>Dimethylamylamine: A Drug Causing Positive Immunoassay Results for Amphetamines</title><author>Vorce, Shawn P. ; Holler, Justin M. ; Cawrse, Brian M. ; Magluilo, Joseph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-8624d9486c43e317c25690f3bac4b9d16226c1f13534d9b7a7ac0daffd31a203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Amines</topic><topic>Amphetamines - urine</topic><topic>Appetite Depressants - metabolism</topic><topic>Biological and medical sciences</topic><topic>Chromatography, Liquid</topic><topic>Drug addictions</topic><topic>False Positive Reactions</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Medical sciences</topic><topic>Substance Abuse Detection - methods</topic><topic>Substance Abuse Detection - standards</topic><topic>Tandem Mass Spectrometry</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vorce, Shawn P.</creatorcontrib><creatorcontrib>Holler, Justin M.</creatorcontrib><creatorcontrib>Cawrse, Brian M.</creatorcontrib><creatorcontrib>Magluilo, Joseph</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of analytical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vorce, Shawn P.</au><au>Holler, Justin M.</au><au>Cawrse, Brian M.</au><au>Magluilo, Joseph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dimethylamylamine: A Drug Causing Positive Immunoassay Results for Amphetamines</atitle><jtitle>Journal of analytical toxicology</jtitle><stitle>Journal of Analytical Toxicology</stitle><addtitle>J Anal Toxicol</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>35</volume><issue>3</issue><spage>183</spage><epage>187</epage><pages>183-187</pages><issn>0146-4760</issn><eissn>1945-2403</eissn><coden>JATOD3</coden><abstract>The Department of Defense (DoD) operates six forensic urine drug-testing laboratories that screen close to 5 million urine samples for amphetamines yearly. Recently, the DoD laboratories have observed a significant decrease in the confirmation rates for amphetamines because of specimens screening positive by two separate immunoassays and confirming negative by gas chromatography-mass spectrometry (GC-MS). Previous studies conducted by the Division of Forensic Toxicology, Armed Force Institute of Pathology (AFIP) utilizing a GC-MS basic drug screen and a designer drug screen revealed no common compound or compound classes as to the cause of the immunoassay-positive results. Additional information obtained from an immunoassay vendor suggested the anorectic compound dimethylamylamine (DMAA) may be the cause of the false-positive screens. An additional 134 false-positive samples were received and analyzed using liquid chromatography-tandem mass spectrometry (LC-MS-MS) for DMAA. LC-MS-MS analysis revealed the presence of DMAA in 92.3% of the false-positive samples at a concentration of approximately 6.0 mg/L DMAA, causing a positive screen on both immunoassay kits.</abstract><cop>Niles, IL</cop><pub>Oxford University Press</pub><pmid>21439156</pmid><doi>10.1093/anatox/35.3.183</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0146-4760 |
| ispartof | Journal of analytical toxicology, 2011-04, Vol.35 (3), p.183-187 |
| issn | 0146-4760 1945-2403 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Amines Amphetamines - urine Appetite Depressants - metabolism Biological and medical sciences Chromatography, Liquid Drug addictions False Positive Reactions Humans Immunoassay Medical sciences Substance Abuse Detection - methods Substance Abuse Detection - standards Tandem Mass Spectrometry Toxicology |
| title | Dimethylamylamine: A Drug Causing Positive Immunoassay Results for Amphetamines |
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