Different pathophysiology underlying animal models of fibromyalgia and neuropathic pain: Comparison of reserpine-induced myalgia and chronic constriction injury rats

► We explore pathophysiology of fibromyalgia-like reserpine-induced myalgia rat model. ► Degenerative changes at the level of primary afferents and spinal cord are not responsible for pain symptoms. ► A sodium channel blocker does not reduce hyperalgesia. ► Dysfunctional brain pain control is involv...

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Veröffentlicht in:	Behavioural brain research 2012, Vol.226 (1), p.242-249
Hauptverfasser:	Nagakura, Yukinori, Takahashi, Masayasu, Noto, Takahisa, Sekizawa, Toshihiro, Oe, Tomoya, Yoshimi, Eiji, Tamaki, Keisuke, Shimizu, Yasuaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavioral psychophysiology Biological and medical sciences Chronic Pain Constriction Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Disease Models, Animal Diseases of the osteoarticular system Fibromyalgia Fibromyalgia - chemically induced Fibromyalgia - physiopathology Fundamental and applied biological sciences. Psychology Hyperalgesia - etiology Hyperalgesia - physiopathology Male Medical sciences Miscellaneous. Osteoarticular involvement in other diseases Nervous system (semeiology, syndromes) Neuralgia - etiology Neuralgia - physiopathology Neurology Neuropathic pain Neuropharmacology Pharmacology. Drug treatments Physical Stimulation Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopharmacology Rats Rats, Sprague-Dawley Reserpine - pharmacology Reserpine-induced myalgia Sciatic Nerve - injuries Sciatic Nerve - physiopathology Sodium channel blocker Substantia nigra
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